Abstract:
:The human homolog of the Drosophila discs large tumor suppressor protein (hDLG) functions as a scaffolding protein that facilitates the transmission of diverse downstream signals. Here we show that hDLG interacts through its PDZ domains with the carboxy-terminal S/TXV motif of the mitochondrial ribosomal protein S-34 (MRP-S34). Our results suggest that hDLG interacts with MRP-S34 prior to entry of MRP-S34 into the mitochondria and may be involved in the trafficking of MRP-S34.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Ogawa F,Adachi S,Kohu K,Shige K,Akiyama Tdoi
10.1016/s0006-291x(02)02887-5subject
Has Abstractpub_date
2003-01-17 00:00:00pages
789-92issue
3eissn
0006-291Xissn
1090-2104pii
S0006291X02028875journal_volume
300pub_type
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journal_title:Biochemical and biophysical research communications
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journal_title:Biochemical and biophysical research communications
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journal_title:Biochemical and biophysical research communications
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