Sequence of the 5'-flanking region of CYP3A5: comparative analysis with CYP3A4 and CYP3A7.

abstract：:The cooperation of phosphofructokinase-2 and fructose-2,6-bisphosphatase is investigated. Experimentally derived rate laws of the kinase and bisphosphatase activities introduced into the respective differential equations permitted to describe the time evolution of fructose-2,6-bisphosphate to quasi-stationary levels. ...

journal_title：Biochemical and biophysical research communications

authors： Kretschmer M,Schellenberger W,Hofmann E

更新日期：1985-09-16 00:00:00

abstract：:We had previously reported a prostaglandin E synthase (bmPGES) in the silkworm Bombyx mori that catalyzes the isomerization of PGH2 to PGE2. The present study aimed to provide a genome-editing characterization of bmPGES in B. mori. Results showed bmPGES gene disruption to result in a reduced content of PGE2. The chang...

journal_title：Biochemical and biophysical research communications

authors： Yamamoto K,Tsubota T,Uno T,Tsujita Y,Yokota S,Sezutsu H,Mita K

更新日期：2020-01-08 00:00:00

abstract：:At high dietary levels in vivo, both 13-cis-retinoic acid and calcium glucarate inhibit the induction of rat mammary tumors by 7,12-dimethylbenz(a)anthracene. The present study shows that sub-optimal dietary levels of each, which individually have no effect on tumor induction, when combined together in the diet, signi...

journal_title：Biochemical and biophysical research communications

authors： Abou-Issa H,Koolemans-Beynen A,Minton JP,Webb TE

更新日期：1989-09-29 00:00:00

abstract：:We developed PeptiSite, a comprehensive and reliable database of biologically and structurally characterized peptide-binding sites, in which each site is represented by an ensemble of its complexes with protein, peptide and small molecule partners. The unique features of the database include: (1) the ensemble site rep...

journal_title：Biochemical and biophysical research communications

authors： Acharya C,Kufareva I,Ilatovskiy AV,Abagyan R

更新日期：2014-03-21 00:00:00

abstract：:Loss-of-function mutations in the DJ-1/PARK7 gene are responsible for early-onset autosomal-recessive Parkinson's disease. DJ-1 is implicated in the protection of neurons from oxidative stress by scavenging hydrogen peroxide and regulating the transcriptional activity of multiple pathways. Here, we attempted to identi...

journal_title：Biochemical and biophysical research communications

authors： Kim SJ,Park YJ,Oh YJ

更新日期：2012-05-25 00:00:00

abstract：:This study defines the total sodium-23 magnetic resonance spectroscopy (23Na MRS) signal from in vivo heterotopic rat heart transplants in the early post-transplant period and examines the utility of this noninvasive method for monitoring allograft rejection. Measurements were performed at 4.7 T. Syngeneic (n = 6) and...

journal_title：Biochemical and biophysical research communications

authors： Waldrop SM,Alexander DZ,Lowry R,Winn KJ,Pearson TC,Constantinidis I

更新日期：1996-06-14 00:00:00

abstract：:Several RNAs, including rRNAs, snRNAs, snoRNAs, and some mRNAs, are known to be localized at specific sites in a cell. Although methods have been established to visualize RNAs in a living cell, no large-scale visual screening of localized RNAs has been performed. In this study, we constructed a genomic library in whic...

journal_title：Biochemical and biophysical research communications

authors： Andoh T,Oshiro Y,Hayashi S,Takeo H,Tani T

更新日期：2006-12-29 00:00:00

abstract：:Fusing recombinant proteins to highly soluble partners is frequently used to prevent aggregation of recombinant proteins in Escherichia coli. Moreover, co-overexpression of prokaryotic chaperones can increase the amount of properly folded recombinant proteins. To understand the solubility enhancement of fusion protein...

journal_title：Biochemical and biophysical research communications

authors： Douette P,Navet R,Gerkens P,Galleni M,Lévy D,Sluse FE

更新日期：2005-08-05 00:00:00

abstract：:The fibroblast growth factors (FGFs) are involved in hematopoiesis and tumorigenesis. However, little is known about the contribution of the FGFs identified within the past 10 years to leukemogenesis. To elucidate whether these FGFs (FGF-8, -9, -10, -11, -12, -13, -14, -16, -17, -18, -19, -20, and -21) are expressed i...

journal_title：Biochemical and biophysical research communications

authors： Nezu M,Tomonaga T,Sakai C,Ishii A,Itoga S,Nishimura M,Matsuo Y,Tagawa M,Nomura F

更新日期：2005-09-30 00:00:00

abstract：:The chemopreventive effect of nitric oxide-releasing aspirin (NO-ASA) against gastrointestinal tumorigenesis was evaluated in Min (APC(Min/+)) mice. NO-ASA consists of a traditional ASA that bears covalently attached to it an NO-releasing moiety. Four groups (N=10) of six-week-old female C57BL/6J APC(Min/+) and the co...

journal_title：Biochemical and biophysical research communications

authors： Williams JL,Kashfi K,Ouyang N,del Soldato P,Kopelovich L,Rigas B

更新日期：2004-01-16 00:00:00

abstract：:Mammalian homologues of the Drosophila trp gene have been invoked as the structural basis for the currents associated with capacitative Ca2+ entry (CCE) in many cell types. Trp homologues are members of a large protein family that may associate as channel subunits providing an explanation for the functional diversity ...

journal_title：Biochemical and biophysical research communications

authors： Garcia RL,Schilling WP

更新日期：1997-10-09 00:00:00

abstract：:The immunological recognition pattern of one of the most commonly used monoclonal antibodies, PHF-1, which detects the paired helical filaments of Alzheimer's disease, exhibits a high degree of similarity with the recognition of a polyclonal antibody, anti-T3P, raised against a synthetic phosphopeptide, GAEIVYKS(Phosp...

journal_title：Biochemical and biophysical research communications

authors： Lang E,Szendrei GI,Lee VM,Otvos L Jr

更新日期：1992-09-16 00:00:00

abstract：:Male rats were exposed to freshly generated cigarette smoke once daily for 4 to 8 weeks. Inhalation of smoke was verified by elevated level of carboxyhemoglobin. Arachidonate metabolism through lipoxygenase and cyclooxygenase pathways in platelets was determined. Cigarette smoking increased 12-lipoxygenase activity si...

journal_title：Biochemical and biophysical research communications

authors： Chang WC,Fukuda S,Tai HH

更新日期：1983-09-15 00:00:00

abstract：:Bacterial dichloromethane dehalogenases catalyze the glutathione-dependent hydrolysis of dichloromethane to formaldehyde and are members of the enzyme superfamily of glutathione S-transferases involved in the detoxification of electrophilic compounds. Numerous protein engineering studies have addressed questions perta...

journal_title：Biochemical and biophysical research communications

authors： Vuilleumier S,Sorribas H,Leisinger T

更新日期：1997-09-18 00:00:00

abstract：:The present study revealed that low density lipoprotein (LDL) obtained from rabbits fed highly purified eicosapentaenoic acid-ethyl ester (EPA-E) (EPA-LDL) was significantly less susceptible to oxidative modification catalyzed by Cu2+ as compared to LDL from rabbits fed a normal diet (control LDL). In a comparison of ...

journal_title：Biochemical and biophysical research communications

authors： Saito H,Chang KJ,Tamura Y,Yoshida S

更新日期：1991-02-28 00:00:00

abstract：:Mouse hepatoma Hepa-1c1c7 (Hepa-1) cells were treated with myristicin to assess the role of myristicin in the process of Cyp1a-1 induction. Treatment of Hepa-1 cells with myristicin increased Cyp1a-1 transcription in a dose-dependent manner as shown by analysis of 7-ethoxyresorufin O-deethylase activity, Cyp1a-1 prote...

journal_title：Biochemical and biophysical research communications

authors： Jeong HG,Lee SS,Kim HK,Yang KH

更新日期：1997-04-28 00:00:00

abstract：:Human myogenic cells have limited ability to proliferate in culture. Although forced expression of telomerase can immortalize some cell types, telomerase alone delays senescence of human primary cultured myogenic cells, but fails to immortalize them. In contrast, constitutive expression of both telomerase and the E7 g...

journal_title：Biochemical and biophysical research communications

authors： Hashimoto N,Kiyono T,Wada MR,Shimizu S,Yasumoto S,Inagawa M

更新日期：2006-10-06 00:00:00

abstract：:Peripheral blood monocytes (PBMC) promote vascular inflammation and atherosclerosis. Chlamydia pneumoniae (Cp) infection of PBMC is found in atherosclerotic patients, appears refractory to antibiotics, and may predispose to vascular damage. In Cp-infected human PBMC we analyzed the role of cyclooxygenase-2 (Cox-2) for...

journal_title：Biochemical and biophysical research communications

authors： Rupp J,Berger M,Reiling N,Gieffers J,Lindschau C,Haller H,Dalhoff K,Maass M

更新日期：2004-07-30 00:00:00

abstract：:The plasma half-lives of glycosylated and unglycosylated alpha 1-proteinase inhibitor-radioactively labeled with [35S]methionine in rat hepatocyte primary cultures - were determined in the rat. Unglycosylated alpha 1-proteinase inhibitor was synthesized by hepatocytes in the presence of tunicamycin. Media from hepatoc...

journal_title：Biochemical and biophysical research communications

authors： Weber W,Steube K,Gross V,Tran-Thi TA,Decker K,Gerok W,Heinrich PC

更新日期：1985-01-16 00:00:00

abstract：:One of the earliest events following stimulation of human platelets with thrombin is a rise in the cytosolic pH, pHi, mediated by Na+/H+ exchange, and an increase in the cytosolic free Ca2+ concentration, [Ca2+]i. In the present study we investigated whether an increase in pHi alone, induced by the Na+/H+ ionophore mo...

journal_title：Biochemical and biophysical research communications

authors： Siffert W,Akkerman JW

更新日期：1989-06-30 00:00:00

abstract：:High sensitivity detection of DNA is essential for genomics. The intrinsic fluorescence from DNA is very weak and almost all methods for detecting DNA rely on the use of extrinsic fluorescent probes. We show that the intrinsic emission from DNA can be enhanced many-fold by spatial proximity to silver island films. Sil...

journal_title：Biochemical and biophysical research communications

authors： Lakowicz JR,Shen B,Gryczynski Z,D'Auria S,Gryczynski I

更新日期：2001-09-07 00:00:00

abstract：:Streptococcus mutans secretes a sucrose-independent branalphang enzyme that utilizes isomaltosaccharides as donors for branalphang formation on dextran. Although the branching enzyme is necessary for the formation of extracellular polysaccharide complexes, the source of the donor for the enzyme is unknown. In this stu...

journal_title：Biochemical and biophysical research communications

authors： Yamashita Y,Hanada N,Takehara T

更新日期：1988-01-29 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by the deposition of β-amyloid (Aβ) peptide in the brain, which is produced by the proteolysis of β-amyloid precursor protein (APP). Recently, the mitochondrial transcription factor 4 (MTERF4), a member of the MTERF family, was implicated in regulating mitochondrial DNA transc...

journal_title：Biochemical and biophysical research communications

authors： Wang XL,Liu Q,Chen GJ,Li ML,Ding YH

更新日期：2017-01-22 00:00:00

abstract：:Phage displayed peptide library was used to select tumor necrosis factor alpha (TNFalpha) binding peptides. After three sequential rounds of biopanning, some linear TNFalpha-binding peptides were identified from a 12-mer peptide library. A consensus sequence (L/M)HEL(Y/F)(L/M)X(W/Y/F), where X might be variable residu...

journal_title：Biochemical and biophysical research communications

authors： Zhang J,Zheng L,Zhao A,Gao B,Liu NL,Wang F,Dong J,Xin ZT,Shao NS,Wang HX,Xue YN

更新日期：2003-10-31 00:00:00

abstract：:Strong temperature dependent low angle X-ray scattering by trifluoroethanol- and hexafluoro-2-propanol-water mixtures was observed in conditions commonly used in NMR work on peptides. At least two types of molecular effects may contribute to the observed scattering: formation of clathrate hydrate-like aggregates of al...

journal_title：Biochemical and biophysical research communications

authors： Kuprin S,Gräslund A,Ehrenberg A,Koch MH

更新日期：1995-12-26 00:00:00

abstract：BACKGROUND:We intended to examine the functional role of microRNA 26 (miR-26a) in regulating H2O2-induced cytotoxicity and apoptosis in RGC-5 cells in vitro. METHOD:Various concentrations of H2O2 (0-1000 μM) were added in RGC-5 culture. Cell cytotoxicity was monitored by viability assay and gene expression level of mi...

journal_title：Biochemical and biophysical research communications

authors： Kang Y,Jia P,Zhao H,Hu C,Yang X

更新日期：2015-05-01 00:00:00

abstract：:Isolated motor endplates from mouse intercostal muscles can be obtained after subcellular fractionation. On these motor endplates, localization of the nicotinic receptor and of the voltage-dependent Na+ channel coincides as demonstrated by double labeling with rhodamine alpha-bungarotoxin and a specific anti-Na+ chann...

journal_title：Biochemical and biophysical research communications

authors： Dreyfus P,Rieger F,Murawsky M,Garcia L,Lombet A,Fosset M,Pauron D,Barhanin J,Lazdunski M

更新日期：1986-08-29 00:00:00

abstract：:The MYST acetyltransferase HBO1 is implicated in the regulation of DNA replication and activities of transcription factors such as the androgen receptor. Since the androgen receptor and NF-kappaB transcription factors crossmodulate their transcriptional activity, we investigated whether HBO1 regulates NF-kappaB signal...

journal_title：Biochemical and biophysical research communications

authors： Contzler R,Regamey A,Favre B,Roger T,Hohl D,Huber M

更新日期：2006-11-10 00:00:00

abstract：:This study investigated regulation of autophagy in slow-twitch soleus and fast-twitch plantaris muscles in fasting-related atrophy. Male Fischer-344 rats were subjected to fasting for 1, 2, or 3 days. Greater weight loss was observed in plantaris muscle than in soleus muscle in response to fasting. Western blot analys...

journal_title：Biochemical and biophysical research communications

authors： Ogata T,Oishi Y,Higuchi M,Muraoka I

更新日期：2010-03-26 00:00:00

abstract：:Isolated rat cerebral cortex cells were able to accumulate L-carnitine and this process was competitively inhibited by 1 mM gamma-aminobutyric acid (GABA) with a shift of Km from 7.8 +/- 1.9 mM to 14.6 +/- 4.0 mM. Addition of GABA also affected distribution of carnitine derivatives. The decrease of acetylcarnitine lev...

journal_title：Biochemical and biophysical research communications

authors： Wawrzeńczyk A,Nałecz KA,Nałecz MJ

更新日期：1995-08-15 00:00:00