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Immortalization of human myogenic progenitor cell clone retaining multipotentiality.

Abstract：

:Human myogenic cells have limited ability to proliferate in culture. Although forced expression of telomerase can immortalize some cell types, telomerase alone delays senescence of human primary cultured myogenic cells, but fails to immortalize them. In contrast, constitutive expression of both telomerase and the E7 gene from human papillomavirus type 16 immortalizes primary human myogenic cells. We have established an immortalized primary human myogenic cell line preserving multipotentiality by ectopic expression of telomerase and E7. The immortalized human myogenic cells exhibit the phenotypic characteristics of their primary parent, including an ability to undergo myogenic, osteogenic, and adipogenic terminal differentiation under appropriate culture conditions. The immortalized cells will be useful for both basic and applied studies aimed at human muscle disorders. Furthermore, immortalization by transduction of telomerase and E7 represents a useful method by which to expand human myogenic cells in vitro without compromising their ability to differentiate.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Hashimoto N,Kiyono T,Wada MR,Shimizu S,Yasumoto S,Inagawa M

doi

10.1016/j.bbrc.2006.08.006

subject

Has Abstract

pub_date

2006-10-06 00:00:00

pages

1383-8

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(06)01778-5

journal_volume

348

pub_type

杂志文章

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