当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Earlier changes in mice after D-galactose treatment were improved by mitochondria derived small peptide MOTS-c.

Earlier changes in mice after D-galactose treatment were improved by mitochondria derived small peptide MOTS-c.

Abstract：

:MOTS-c, as a mitochondria derived peptide, exerts benefits for insulin resistance in HFD mice and against various stresses in an AMPK dependent way. Here, in the D-galactose chronic injection models, exogenous MOTS-c was given to determine its direct anti-aging effects. The body weight, insulin sensitivity and blood glucose were determined with mild differences. Tissue morphology analyses disclosed that liver, visceral fat and dermal skin, all displayed aberrant lipid depositions in the D-galactose mice. MOTS-c treatment largely alleviated the lipid accumulations, corresponding with positive changes in mitochondria dynamics, observed in liver transmission electron microscopy and in altered mRNA levels of Drp1 and mitofusins. Notably, the aging phenotypes of small intestine tract were more obvious, including histological defects and lower Ki67 levels, plus with the higher levels of DNA stress, such as P21 and P16, as well as mitochondria dynamics. Collectively, these data provided the direct evidence to support that exogenous givings of MOTS-c prevented abnormal fat accumulations in D-gal mice, putatively via improvement of mitochondria dynamic related pathways.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Li Q,Lu H,Hu G,Ye Z,Zhai D,Yan Z,Wang L,Xiang A,Lu Z

doi

10.1016/j.bbrc.2019.03.194

subject

Has Abstract

pub_date

2019-05-28 00:00:00

pages

439-445

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(19)30601-1

journal_volume

513

pub_type

杂志文章

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