当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > EMT-inducing transcription factor ZEB1-associated resistance to the BCL-2/BCL-XL inhibitor is overcome by BIM upregulation in ovarian clear cell carcinoma cells.

EMT-inducing transcription factor ZEB1-associated resistance to the BCL-2/BCL-XL inhibitor is overcome by BIM upregulation in ovarian clear cell carcinoma cells.

Abstract：

:Ovarian clear cell carcinoma (OCCC) is an aggressive subtype of epithelial ovarian cancer, which generally exhibits chemoresistance. Effective therapy for OCCC is currently unavailable, requiring the development of new therapeutic strategies. ABT-263 (navitoclax), an inhibitor of the anti-apoptotic BCL-2/BCL-XL, has a potent ability of inducing death in cancer cells; however, the therapeutic effect of ABT-263 in OCCC remains unclear. Epithelial cells undergo epithelial-mesenchymal transition (EMT) to acquire a mesenchymal phenotype, which is known to contribute to the development of resistance against therapeutic agents. In this study, we revealed that the sensitivity of OCCC cells to ABT-263 was associated with the epithelial/mesenchymal status of the cells. While the OCCC cells with an epithelial phenotype were ABT-263-sensitive, those with a mesenchymal phenotype were ABT-263-resistant, which was accompanied by an insufficient expression of the pro-apoptotic BH3 protein BIM. Mechanistically, the EMT-inducing transcription factor, ZEB1 down-regulated BIM transcription by binding to BIM promoter, resulting in resistance to ABT-263. It is noteworthy that ZEB1-associated ABT-263 resistance was overcome by an HDAC inhibitor, FK228 (romidepsin), through the up-regulation of BIM. In summary, our study provides evidence for a mechanism for ABT-263 resistance in OCCC cells as well as a potential therapeutic strategy to overcome it.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Inoue-Yamauchi A,Oda H

doi

10.1016/j.bbrc.2020.03.139

subject

Has Abstract

pub_date

2020-06-04 00:00:00

pages

612-617

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(20)30636-7

journal_volume

526

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • Plasma albumin cysteinylation is regulated by cystathionine beta-synthase.

    abstract：:High homocysteine (Hcy) levels are a well-known independent risk factor for endothelial damage in atherosclerosis. We examined whether a rat intestinal model of ischemia-reperfusion was associated with high Hcy and with the modification of plasma albumin into cysteinylated species (CysAlb). The three treatment groups ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.10.191

    authors： Bar-Or D,Curtis CG,Sullivan A,Rael LT,Thomas GW,Craun M,Bar-Or R,Maclean KN,Kraus JP

    更新日期：2004-12-24 00:00:00

  • A new sialoglycoprotein from rat seminal vesicle and its association with semen coagulum.

    abstract：:By radiolabeling using NaIO4/[3H]KBH4, a new sialoglycoprotein with Mr of 19,000 was found in the secretion of rat seminal vesicle. It was shown to interact non-covalently with semen coagulum. It existed in three acidic forms with pI values of 4.1, 3.7 and 2.9 and possessed high contents of sialic acids and acidic ami...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(86)90503-6

    authors： Limpaseni T,Chulavatnatol M

    更新日期：1986-04-29 00:00:00

  • Regional distribution of neuromedin K and neuromedin L in rat brain and spinal cord.

    abstract：:Neuromedin K and neuromedin L are novel mammalian tachykinins isolated from porcine spinal cord. We have developed a highly sensitive radioimmunoassay for neuromedin K. Since the radioimmunoassay for neuromedin K has significant crossreactivity with neuromedin L and substance P, we can simultaneously determine the tis...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(84)91019-2

    authors： Minamino N,Masuda H,Kangawa K,Matsuo H

    更新日期：1984-11-14 00:00:00

  • Tamoxifen activates hypothalamic l-dopa synthesis to stimulate ovarian estrogen production in chicken.

    abstract：:Estrogen is the primary sex hormone responsible for the development and modulation of the female reproductive system in all vertebrates including avian species. The actions of estrogen are mediated by the estrogen receptor, which could be modulated by the selective estrogen receptor modulator tamoxifen (TAM). In this ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.01.182

    authors： Mao Y,Wu X,An L,Li X,Li Z,Zhu G

    更新日期：2018-02-19 00:00:00

  • Probing a CMP-Kdn synthetase by 1H, 31P, and STD NMR spectroscopy.

    abstract：:CMP-Kdn synthetase catalyses the reaction of sialic acids (Sia) and cytidine-5'-triphosphate (CTP) to the corresponding activated sugar nucleotide CMP-Sia and pyrophosphate PP(i). STD NMR experiments of a recombinant nucleotide cytidine-5'-monophosphate-3-deoxy-d-glycero-d-galacto-nonulosonic acid synthetase (CMP-Kdn ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.12.040

    authors： Haselhorst T,Münster-Kühnel AK,Stolz A,Oschlies M,Tiralongo J,Kitajima K,Gerardy-Schahn R,von Itzstein M

    更新日期：2005-02-11 00:00:00

  • Baculovirus-mediated high level expression of a mammalian DNA methyltransferase.

    abstract：:The murine C-5 cytosine DNA methyltransferase (MTase, E.C.2.1.1.37) containing a hexahistidine affinity leader peptide has been expressed at levels which are at least 50-fold higher than previously reported. The recombinant enzyme has activity levels similar to the wild-type enzyme. The recombinant polypeptide binds t...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1994.2562

    authors： Glickman JF,Reich NO

    更新日期：1994-11-15 00:00:00

  • 3"-Azido-3'-deoxythymidine and 2',3'-dideoxycytidine do not inhibit gene-specific DNA repair in hamster cells.

    abstract：:3"-Azido-3'-deoxythymidine (AZT) was the first approved drug for the treatment of the AIDS; however, despite its usefulness, AZT often produces side effects that require cessation of therapy. 2',3'-Dideoxycytidine (ddC) is a related anti-retroviral agent in advanced stages of clinical testing. A previous report demons...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.1323

    authors： Link CJ Jr,Bohr VA

    更新日期：1995-03-08 00:00:00

  • Nucleoside triphosphate binding and hydrolysis by histone H1.

    abstract：:We present here further evidence supporting that histone H1 contains a nucleotide binding site interacting e.g. with ADP, ATP, GDP and GTP. The finding is in accordance with the previous observation that nucleotides modulate recognition of DNA by H1. Most interestingly, H1 appears to be capable of hydrolyzing NTPs and...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(05)80146-9

    authors： Mannermaa RM,Oikarinen J

    更新日期：1992-01-15 00:00:00

  • Nucleotide sequence of the complementary DNA for turkey growth hormone.

    abstract：:Near-full length complementary DNA (cDNA) clones encoding turkey growth hormone (GH) have been isolated from a pituitary library. The longer of the two turkey GH cDNA clones that were sequenced is 803 base pairs (bp) in length and contains 41 nucleotides of the 5'-untranslated region (UTR), an open reading frame of 64...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(05)80880-0

    authors： Foster DN,Kim SU,Enyeart JJ,Foster LK

    更新日期：1990-12-31 00:00:00

  • Temperature dependence of the flexural rigidity of single microtubules.

    abstract：:Although the flexural rigidity of a microtubule has previously been estimated by various methods, its temperature dependence has never been systematically examined. Here, we measured the flexural rigidity of a single taxol-stabilized microtubule from thermal fluctuation of the free end of a microtubule, the other end ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.11.162

    authors： Kawaguchi K,Ishiwata S,Yamashita T

    更新日期：2008-02-15 00:00:00

  • Regulation of lipoprotein lipase secretion by mouse peritoneal macrophages.

    abstract：:Resident mouse peritoneal macrophages in culture spontaneously secrete lipoprotein lipase. Secretion of lipoprotein lipase was 10-fold greater in thioglycollate-elicited and 6-fold greater in mineral oil-elicited macrophages. The increase in enzyme secretion was dependent on protein synthesis and glycosylation of the ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(87)90443-8

    authors： Goldberg DI,Khoo JC

    更新日期：1987-01-15 00:00:00

  • Effect of aphidicolin on the elongation step of adenovirus DNA replication in vitro.

    abstract：:Adenovirus DNA synthesis carried out in vitro was inhibited by the aphidicolin. However, 30% of the DNA synthesis was resistant to aphidicolin even at a concentration of 200 micrograms/ml. When the distribution patterns of the radioactivity of the products synthesized in the presence of 50 micrograms/ml of the drug wa...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(83)90435-7

    authors： Ariga H

    更新日期：1983-05-31 00:00:00

  • Human very-long-chain acyl-CoA synthetase: cloning, topography, and relevance to branched-chain fatty acid metabolism.

    abstract：:Very-long-chain acyl-CoA synthetases (VLCS) activate very-long-chain fatty acids (VLCFA) containing 22 or more carbons to their CoA derivatives. We cloned the human ortholog (hVLCS) of the gene encoding the rat liver enzyme (rVLCS). Both hVLCS and rVLCS contain 620 amino acids, are expressed primarily in liver and kid...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1999.0510

    authors： Steinberg SJ,Wang SJ,Kim DG,Mihalik SJ,Watkins PA

    更新日期：1999-04-13 00:00:00

  • Transient receptor potential ankyrin 1 channels are involved in spontaneous peptide hormone release from astrocytes.

    abstract：:Astrocytes, a large population of glial cells, detect neurotransmitters and respond by increasing intracellular Ca2+ concentration ([Ca2+]i) and releasing chemical molecules called gliotransmitters. Recently discovered Ca2+ influx through transient receptor potential ankyrin 1 (TRPA1) channels is reported to cause spo...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.05.097

    authors： Takizawa M,Harada K,Nakamura K,Tsuboi T

    更新日期：2018-07-02 00:00:00

  • Molecular cloning, genomic organization and developmental regulation of a novel receptor from Drosophila melanogaster structurally related to gonadotropin-releasing hormone receptors for vertebrates.

    abstract：:After screening the data base of the Berkeley Drosophila Genome Project with a sequence coding for the transmembrane region of a G protein-coupled receptor, we found that Drosophila might contain a gene coding for a receptor that is structurally related to the Gonadotropin-Releasing Hormone (GnRH) receptors from verte...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1998.9230

    authors： Hauser F,Søndergaard L,Grimmelikhuijzen CJ

    更新日期：1998-08-28 00:00:00

  • Glycolysis and lipid synthesis in brown adipose tissue during ageing in the rat.

    abstract：:The maximal activity of the enzymes hexokinase and 6-phosphofructokinase were measured in interscapular brown adipose tissue during ageing in the rat. The activity of these glycolytic enzymes increased markedly during the suckling-weaning transition (20-22 days of age), but from 30 to 100 days of age the activities pe...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(86)91107-1

    authors： Simpson ML,Cooney GJ,Caterson ID,Newsholme EA

    更新日期：1986-10-15 00:00:00

  • Biochemical deficiencies of coenzyme Q10 in HIV-infection and exploratory treatment.

    abstract：:AIDS patients (2 groups) had a blood deficiency (p less than 0.001) of coenzyme Q10 vs. 2 control groups. AIDS patients had a greater deficiency (p less than 0.01) than ARC patients. ARC patients had a deficiency (p less than 0.05) vs. control. HIV-infected patients had a deficiency (p less than 0.05) vs. control. The...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(88)81179-3

    authors： Folkers K,Langsjoen P,Nara Y,Muratsu K,Komorowski J,Richardson PC,Smith TH

    更新日期：1988-06-16 00:00:00

  • Expression of dopamine-associated genes on conjunctiva stromal-derived human mesenchymal stem cells.

    abstract：:Parkinson's disease (PD) is neurodegenerative diseases caused by the loss of dopaminergic neurons in the substantia nigra pars compacta. Stem cell therapy is one of the promising strategies in helping to cure PD. In the present study, human mesenchymal stem cells (MSCs) from eye conjunctiva stromal cells were differen...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.09.148

    authors： Nadri S,Soleimani M,Mobarra Z,Amini S

    更新日期：2008-12-12 00:00:00

  • In vitro synthesis of a plant phospholipid transfer protein: a study by high performance liquid chromatography.

    abstract：:In order to study the biosynthesis of a plant phospholipid transfer protein (PLTP), poly (A)+RNAs have been prepared from maize seedlings and translated in vitro with a rabbit reticulocyte lysate. The newly synthesized proteins were then separated by fast protein liquid chromatography (FPLC) followed by SDS-PAGE or by...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(85)91843-1

    authors： Tchang F,Laroche-Raynal M,Vergnolle C,Demandre C,Douady D,Grosbois M,Guerbette F,Delseny M,Kader JC

    更新日期：1985-11-27 00:00:00

  • Aldosterone promotes fibronectin production through a Smad2-dependent TGF-beta1 pathway in mesangial cells.

    abstract：:Accumulating evidence demonstrates that aldosterone can cause extra-cellular matrix (ECM) accumulation, in addition to regulating sodium and potassium homeostasis. Increased extra-cellular matrix production by renal glomerular mesangial cells has been suggested to be involved in pathogenesis of glomerular sclerosis. T...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2006.07.057

    authors： Lai L,Chen J,Hao CM,Lin S,Gu Y

    更新日期：2006-09-15 00:00:00

  • The metallo-disintegrin ADAM10 (MADM) from bovine kidney has type IV collagenase activity in vitro.

    abstract：:The metallo-disintegrins (ADAMs) are a family of mammalian proteins with significant amino acid sequence identity and a domain organisation similar to the snake venom metalloproteinases (reprolysins). They have been implicated in a wide variety of processes such as cell-cell and cell matrix adhesion and proteolysis of...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1998.8485

    authors： Millichip MI,Dallas DJ,Wu E,Dale S,McKie N

    更新日期：1998-04-17 00:00:00

  • Rho signaling inhibitor, CCG-1423, inhibits axonal elongation and dendritic complexity of rat cortical neurons.

    abstract：:CCG-1423, a chemical inhibitor of Rho signaling, blocks serum response factor (SRF)/megakaryoblastic leukemia 1 (MKL1)-mediated gene expression by inhibiting the nuclear accumulation of MKL1. Several studies have suggested that CCG-1423 interacts not only with MKL1, which has a critical role in the regulation of neuro...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.08.071

    authors： Kikuchi K,Shiota J,Yamada T,Ishikawa M,Ihara D,Fukuchi M,Tsuda M,Tabuchi A

    更新日期：2017-10-21 00:00:00

  • Synthesis and characterization of O6-(2-chloroethyl)guanine: a putative intermediate in the cytotoxic reaction of chloroethylnitrosoureas with DNA.

    abstract：:The chloroethylnitrosoureas are useful antitumor agents which evidently exert a significant part of their cytotoxic action through the formation of a unique 1-(3-deoxycytidyl), 2-(1-deoxyguanosinyl)ethane cross-link in DNA. It has been suggested that this cross-link is formed from O6-(2-chloro-ethyl)guanine, an initia...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(87)80249-8

    authors： Parker S,Kirk MC,Ludlum DB

    更新日期：1987-11-13 00:00:00

  • Abscisic acid ameliorates the systemic sclerosis fibroblast phenotype in vitro.

    abstract：:The phytohormone abscisic acid (ABA) has been recently identified as an endogenous hormone in humans, regulating different cell functions, including inflammatory processes, insulin release and glucose uptake. Systemic sclerosis (SSc) is a chronic inflammatory disease resulting in fibrosis of skin and internal organs. ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.04.107

    authors： Bruzzone S,Battaglia F,Mannino E,Parodi A,Fruscione F,Basile G,Salis A,Sturla L,Negrini S,Kalli F,Stringara S,Filaci G,Zocchi E,Fenoglio D

    更新日期：2012-05-25 00:00:00

  • Knockout mice lacking cPGES/p23, a constitutively expressed PGE2 synthetic enzyme, are peri-natally lethal.

    abstract：:Cytosolic prostaglandin (PG) E synthase (cPGES) is constitutively expressed in various cells and regulates cyclooxygenase (COX)-1-dependent immediate PGE(2) generation. Its primary structure is identical to co-chaperone p23, a heat shock protein 90 (Hsp90)-binding protein. We have revealed that Hsp90 regulated both cP...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.07.180

    authors： Nakatani Y,Hokonohara Y,Kakuta S,Sudo K,Iwakura Y,Kudo I

    更新日期：2007-10-19 00:00:00

  • 2,3,7,8-Tetrachlorodibenzo-p-dioxin alters retinoic acid receptor function in human keratinocytes.

    abstract：:Actions of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on all-trans-retinoic acid (trans-RA) binding to retinoic acid receptors (RARs) in cultured human keratinocytes (SCC-12F) was investigated. TCDD and trans-RA elicited opposing actions on the production of biologically active TGF-beta. TCDD exposure caused concentra...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1998.8173

    authors： Lorick KL,Toscano DL,Toscano WA Jr

    更新日期：1998-02-24 00:00:00

  • Interrelationship between activation of matrix metalloproteinases and mitochondrial dysfunction in the development of diabetic retinopathy.

    abstract：:Mitochondria dysfunction plays a significant role in the apoptosis of retinal cells. Diabetes activates retinal matrix metalloproteinases (MMP-9 and MMP-2), damages retinal mitochondria and activates the apoptotic machinery. This study is to investigate the temporal relationship between the activation of retinal MMPs ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2013.07.066

    authors： Santos JM,Tewari S,Lin JY,Kowluru RA

    更新日期：2013-09-06 00:00:00

  • Lesioned low density lipoprotein in atherosclerotic apolipoprotein E-deficient transgenic mice and in humans is oxidized and aggregated.

    abstract：:We analyzed lesioned LDL in both atherosclerotic humans and in the apo E deficient (E degree) mice and compared its characteristics to plasma LDL. Lesioned LDL, in comparison to plasma LDL, was minimally oxidized and aggregated. Upon incubation of E degree-aortic lesions with 125[I]-labeled LDL, a time-dependent oxida...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.2651

    authors： Aviram M,Maor I,Keidar S,Hayek T,Oiknine J,Bar-El Y,Adler Z,Kertzman V,Milo S

    更新日期：1995-11-13 00:00:00

  • Resveratrol arrests the cell division cycle at S/G2 phase transition.

    abstract：:Resveratrol (3,5,4'-trihydroxystilbene) is a naturally occurring phytoalexin, found in grapes and wine, which has been reported to exert a variety of important pharmacological effects. We have investigated the activity of resveratrol on proliferation and differentiation of the promyelocitic cell line HL-60. A concentr...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1998.9263

    authors： Ragione FD,Cucciolla V,Borriello A,Pietra VD,Racioppi L,Soldati G,Manna C,Galletti P,Zappia V

    更新日期：1998-09-08 00:00:00

  • Tetraphenylborate potentiates the respiratory inhibition by the dopaminergic neurotoxin MPP+ in both electron transport particles and intact mitochondria.

    abstract：:The cytotoxicity of 1-methyl-4-phenylpyridinium (MPP+) is believed to arise as a consequence of its time- and energy-dependent accumulation inside mitochondria, followed by inhibition of electron transport at Complex I of the respiratory chain. Consistent with our proposal that the accumulation of MPP+ represents a pa...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(89)92672-7

    authors： Sayre LM,Wang F,Hoppel CL

    更新日期：1989-06-15 00:00:00