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Regional distribution of neuromedin K and neuromedin L in rat brain and spinal cord.

Abstract：

:Neuromedin K and neuromedin L are novel mammalian tachykinins isolated from porcine spinal cord. We have developed a highly sensitive radioimmunoassay for neuromedin K. Since the radioimmunoassay for neuromedin K has significant crossreactivity with neuromedin L and substance P, we can simultaneously determine the tissue concentrations of neuromedin K, neuromedin L and substance P after separation of the tissue extracts by reverse phase high performance liquid chromatography. Substance P is found to be the most abundant mammalian tachykinin in every brain region. The ratio of the concentration of substance P to neuromedin K is small in cerebral cortex and large in medulla-pons, while that of substance P to neuromedin L is rather constant in a range of 2.0-2.5. In spinal cord, dorsal half contains more neuromedin K and L than ventral half as is the case with substance P. These results indicate that both neuromedin K and L are endogenous mammalian tachykinins with specific physiological functions.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Minamino N,Masuda H,Kangawa K,Matsuo H

doi

10.1016/0006-291x(84)91019-2

subject

Has Abstract

pub_date

1984-11-14 00:00:00

pages

731-8

issue

3

eissn

0006-291X

issn

1090-2104

pii

0006-291X(84)91019-2

journal_volume

124

pub_type

杂志文章

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