Amino acid sequence from degu islet amyloid-derived insulin shows unique sequence characteristics.

abstract：:Restenosis after angioplasty is thought to be caused by proliferation and migration of vascular smooth muscle cells (VSMCs), and it is a most serious problem in medical treatment. A low dose (50 ng/ml) of manumycin A, an inhibitor of p21(ras) (ras) farnesylation, significantly inhibited proliferation of rat VSMCs stim...

journal_title：Biochemical and biophysical research communications

authors： Kouchi H,Nakamura K,Fushimi K,Sakaguchi M,Miyazaki M,Ohe T,Namba M

更新日期：1999-11-02 00:00:00

abstract：:The production rate of dengue viruses (DENVs), especially low-passage virus isolates, is low, and, therefore, the isolates are generally used only after several passages. However, in vitro passages could induce mutation(s). In this study, we established a system for the characterization of low-passage viral isolates u...

journal_title：Biochemical and biophysical research communications

authors： Kurosu T,Khamlert C,Phanthanawiboon S,Ikuta K,Anantapreecha S

更新日期：2010-04-02 00:00:00

abstract：:The selectivity filter and adjacent regions in the bacterial KcsA and inwardly rectifying K(+) (Kir) channels reveal significant conformational changes that cause the channel pore to transition from an activated to inactive state (C-type inactivation) once the channel is open. The meshwork of residues stabilizing the ...

journal_title：Biochemical and biophysical research communications

authors： Raja M

更新日期：2011-09-16 00:00:00

abstract：:Activation of the classical complement pathway has been proposed as a mechanism of neurodegeneration in Alzheimer's disease. This activation is a result of the binding of C1q to amyloid beta-peptide (A beta). Recent work has shown that A beta/C1q binding has an additional consequence: enhanced formation of the neuroto...

journal_title：Biochemical and biophysical research communications

authors： Webster S,Glabe C,Rogers J

更新日期：1995-12-26 00:00:00

abstract：UNLABELLED:The L-arginine-nitric oxide (NO) pathway was investigated in human internal mammary artery (HIMA) in vitro. HIMA rings were mounted in organ bath, and then incubated in Krebs buffer for 1 to 8 hrs, relaxing agents were tested. Under these conditions, L-arginine (0.1 microM - 1 mM) elicited only minor relaxat...

journal_title：Biochemical and biophysical research communications

authors： Qi X,Chen D,Nottin R,Mace L,Herve P,Weiss M

更新日期：1993-08-31 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta) is an inhibitor of the proliferation of bovine aortic endothelial cells in culture. Basal cell growth in serum-containing medium and cell proliferation stimulated by fibroblast growth factor (FGF) are inhibited by TGF-beta in a dose-dependent manner. Half-maximal inhibition o...

journal_title：Biochemical and biophysical research communications

authors： Fràter-Schröder M,Müller G,Birchmeier W,Böhlen P

更新日期：1986-05-29 00:00:00

abstract：:Peripheral noxious stimulation leads to phosphorylation and thereby activation of the transcription factor CREB in the spinal cord. CREB phosphorylation occurs mainly at serine 133, but the phosphorylation site at serine 142 may also be important. We investigated the impact of spinal CREB protein levels and phosphoryl...

journal_title：Biochemical and biophysical research communications

authors： Niederberger E,Ehnert C,Gao W,Coste O,Schmidtko A,Popp L,Gall CV,Korf HW,Tegeder I,Geisslinger G

更新日期：2007-10-12 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by the formation of extracellular amyloid plaques containing the amyloid β-protein (Aβ) within the parenchyma of the brain. Aβ42, which is 42 amino acids in length, is considered to be the key pathogenic factor in AD. Iron deposition is found abundantly in the amyloid plaques ...

journal_title：Biochemical and biophysical research communications

authors： Shen X,Liu J,Fujita Y,Liu S,Maeda T,Kikuchi K,Obara T,Takebe A,Sayama R,Takahashi T,Matsue A,Sera K,Michikawa M,Komano H,Zou K

更新日期：2019-05-14 00:00:00

abstract：:Human platelets are less responsive to PAF at 37 degrees than at 25 degrees. They can be desensitized to the effects of PAF by pre-exposure to small concentrations. In both cases desensitization appears to be accompanied by a decreased affinity of the high affinity site for PAF rather than loss of binding sites. Alter...

journal_title：Biochemical and biophysical research communications

authors： Chesney CM,Pifer DD,Huch KM

更新日期：1985-02-28 00:00:00

abstract：:It has been reported that changes in deoxynucleotide pool levels following exposure to UV might lead to an overestimation of the UV-induced depression in DNA synthesis as analyzed by incorporation of 3H-thymidine (1). We attempted to determine the importance of such pool effects in two ways. First, we examined the gra...

journal_title：Biochemical and biophysical research communications

authors： Griffiths TD,Ling SY

更新日期：1984-09-17 00:00:00

abstract：:Studies of islet neogenesis have suggested that the regeneration of islet cells can be achieved through redifferentiation of pre-existing islet cells. However, this hypothesis is largely unproven and fails to account for the diversity of observed islet neogenesis. Here we show that cultured neonatal pancreatic cells d...

journal_title：Biochemical and biophysical research communications

authors： Zhao W,Hirose T,Ishikawa M,Oshima Y,Hirai S,Ohno S,Taniguchi H

更新日期：2007-01-05 00:00:00

abstract：:Butein, a plant polyphenol, was shown to be a specific protein tyrosine kinase inhibitor. This compound inhibited not only the epidermal growth factor (EGF)-stimulated auto-phosphotyrosine level of EGF receptor in HepG2 cells but also tyrosine-specific protein kinase activities of EGF receptor (IC50 = 65 microM) and p...

journal_title：Biochemical and biophysical research communications

authors： Yang EB,Zhang K,Cheng LY,Mack P

更新日期：1998-04-17 00:00:00

abstract：:The narrow leaf1 (nal1) mutant of rice (Oryza sativa L.) exhibits a narrow leaf phenotype. Previous studies have shown that NAL1 modulates leaf size by affecting vein patterning and cell division; however, the underlying mechanism remains unclear. Here, we report that the nal1 mutant shows reduced size of the leaf aba...

journal_title：Biochemical and biophysical research communications

authors： Lin L,Zhao Y,Liu F,Chen Q,Qi J

更新日期：2019-08-27 00:00:00

abstract：:Experiments were undertaken to examine the effects of reduced (GSH) and oxidized (GSSG) glutathione on lipid peroxidation of rat liver microsomes. Dependence on microsomal alpha-tocopherol was shown for the GSH inhibition of lipid peroxidation. However, when GSH (5 mM) and GSSG (2.5 mM) were combined in the assay syst...

journal_title：Biochemical and biophysical research communications

authors： Scholz RW,Graham KS,Reddy CC

更新日期：1990-01-30 00:00:00

abstract：:The effect of opioids on NO production by LPS-stimulated murine macrophages J774 has been investigated. Morphine (mu and k opioid receptor agonist), DAGO (selective mu receptor agonist) and U50-488H (selective k receptor agonist), added (10(-10)-10(-6) M) to the cells 0.5 h before activation with LPS, significantly in...

journal_title：Biochemical and biophysical research communications

authors： Iuvone T,Capasso A,D'Acquisto F,Carnuccio R

更新日期：1995-07-26 00:00:00

abstract：:Interleukin-6 (IL-6) signal is transduced through a membrane glycoprotein gp130, which associates with the IL-6 receptor alpha chain (IL-6R alpha) in the presence of IL-6. We prepared monoclonal antibodies (mAbs) specific to murine gp130 by immunizing rats and hamsters with a chimeric molecule consisting of the extrac...

journal_title：Biochemical and biophysical research communications

authors： Matsuda T,Hirano T

更新日期：1994-07-15 00:00:00

abstract：:Chromatography of a DNA polymerase preparation from mitochondria of Saccharomyces cerevisiae on DNA-cellulose column, using Tris-HCl (pH 7.5) buffer containing 0.6 M NaCl as eluent, was found to yield a fraction exhibiting DNA primase-like activity free of DNA polymerase. This fraction could support the synthesis of 1...

journal_title：Biochemical and biophysical research communications

authors： Desai SD,Pasupathy K,Chetty KG,Pradhan DS

更新日期：1989-04-28 00:00:00

abstract：:When c-Src and v-Src were immunoprecipitated together from hamster fibroblasts transformed by Rous sarcoma virus containing v-src oncogene, the total Src activity was almost threefold higher compared to c-Src activity in the control cells. The activity of v-Src immunoprecipitated separately, however, accounting for on...

journal_title：Biochemical and biophysical research communications

authors： Tuhácková Z,Vojtechová M,Hlavácek J,Ruzzene M,Sovová V,Pinna LA

更新日期：2002-01-18 00:00:00

abstract：:Astrocytes, a large population of glial cells, detect neurotransmitters and respond by increasing intracellular Ca2+ concentration ([Ca2+]i) and releasing chemical molecules called gliotransmitters. Recently discovered Ca2+ influx through transient receptor potential ankyrin 1 (TRPA1) channels is reported to cause spo...

journal_title：Biochemical and biophysical research communications

authors： Takizawa M,Harada K,Nakamura K,Tsuboi T

更新日期：2018-07-02 00:00:00

abstract：:We have previously reported that 90K/Mac-2 binding protein (M2BP) was highly expressed in lung cancer and that M2BP-specific immunity was observed in many of cancer patients. In this study, we analyzed the ability of 11 M2BP-derived oligopeptides with an HLA-A*0201-binding motif to induce M2BP-specific cytotoxic T lym...

journal_title：Biochemical and biophysical research communications

authors： Ozaki Y,Kontani K,Teramoto K,Fujita T,Tezuka N,Sawai S,Watanabe H,Fujino S,Asai T,Ohkubo I

更新日期：2004-05-14 00:00:00

abstract：:The 65 kDa C8-binding protein or homologous restriction factor (C8bp/HRF) protects cells from complement (C)-mediated lysis by binding to C8 and abrogating lytic channel formation. Human C8bp/HRF is shown here to be immunologically related to human C8 and C9 and to murine lymphocyte poreforming protein (PFP, perforin)...

journal_title：Biochemical and biophysical research communications

authors： Young JD,Rosse WF,Hasselkus-Light CS

更新日期：1990-01-30 00:00:00

abstract：:We investigated the genomic organization of pancreatic zymogen granule membrane-associated protein GP2, a GPI-anchored protein exhibiting self-aggregation at acidic pH, in order to construct a gene-knockout mouse. Cloning and analysis of lambda clones encoding GP2 from 129 Svj mouse genomic DNA libraries showed that t...

journal_title：Biochemical and biophysical research communications

authors： Kobayashi K,Yanagihara K,Ishiguro K,Fukuoka S

更新日期：2004-09-17 00:00:00

abstract：:Ovarian clear cell carcinoma (OCCC) is an aggressive subtype of epithelial ovarian cancer, which generally exhibits chemoresistance. Effective therapy for OCCC is currently unavailable, requiring the development of new therapeutic strategies. ABT-263 (navitoclax), an inhibitor of the anti-apoptotic BCL-2/BCL-XL, has a...

journal_title：Biochemical and biophysical research communications

authors： Inoue-Yamauchi A,Oda H

更新日期：2020-06-04 00:00:00

abstract：:As a model host, the nematode Caenorhabditis elegans has been used for studying unknown pathogen-host interactions and identifying novel virulence factors in bacterial pathogens. Among the bacterial pathogens that can induce death of C. elegans is enterohemorrhagic Escherichia coli (EHEC) O157:H7, a major serotype of ...

journal_title：Biochemical and biophysical research communications

authors： Youn M,Lee KM,Kim SH,Lim J,Yoon JW,Park S

更新日期：2013-07-05 00:00:00

abstract：:It has recently been reported that expression of heme oxygenase-1 (HO-1) plays a protective role against many diseases. Furthermore, n-3 polyunsaturated fatty acids (PUFAs) were shown to induce HO-1 expression in several cells in vitro, and in a few cases also in vivo. However, very few reports have demonstrated that ...

journal_title：Biochemical and biophysical research communications

authors： Nakagawa F,Morino K,Ugi S,Ishikado A,Kondo K,Sato D,Konno S,Nemoto K,Kusunoki C,Sekine O,Sunagawa A,Kawamura M,Inoue N,Nishio Y,Maegawa H

更新日期：2014-01-17 00:00:00

abstract：:The effect of human recombinant interferons (IFNs) alpha and gamma on the transcription of Herpes Simplex virus type-1 (HSV-1) immediate early (IE) genes has been studied. Human amniotic cells (WISH) were transfected with a chimaeric plasmid containing the regulatory region of the HSV-1 IE genes controlling the expres...

journal_title：Biochemical and biophysical research communications

authors： De Stasio PR,Taylor MW

更新日期：1989-03-15 00:00:00

abstract：:Previous studies have suggested that 1,25(OH)2D3, the active form of vitamin D3, may increase the survival of bone-forming osteoblasts through an inhibition of apoptosis. On the other hand, vitamin D3 has also been shown to trigger apoptosis in human cancer cells, including osteosarcoma-derived cell lines. In the pres...

journal_title：Biochemical and biophysical research communications

authors： Witasp E,Gustafsson AC,Cotgreave I,Lind M,Fadeel B

更新日期：2005-05-13 00:00:00

abstract：:Retroviruses and retrotransposons depend on their host cells to complete their replication cycles. In many cases, the viral step of reverse transcription is blocked when host cells are arrested in their cell cycle and this block is only released when the host cell resumes division. It has previously been shown that a ...

journal_title：Biochemical and biophysical research communications

authors： Karst SM,Sadeghi N,Menees TM

更新日期：1999-01-27 00:00:00

abstract：:Previously, we have investigated the potential for a pro-oxidant interaction of iron and ascorbate in vivo in iron and ascorbate cosupplementation or ascorbate supplementation studies. In this study, for the first time, the effects of iron supplementation on oxidative damage to DNA in healthy individuals with plasma a...

journal_title：Biochemical and biophysical research communications

authors： Proteggente AR,England TG,Rice-Evans CA,Halliwell B

更新日期：2001-10-19 00:00:00

abstract：:Individual yeast colonies produce pulses of volatile ammonia separated by phases of medium acidification. Colonies of Saccharomyces cerevisiae mutant defective in the general amino acid permease, Gap1p, exhibit decreased ammonia production. Mutations in the S. cerevisiae amino acid sensor SPS completely abolish the co...

journal_title：Biochemical and biophysical research communications

authors： Zikánová B,Kuthan M,Ricicová M,Forstová J,Palková Z

更新日期：2002-06-28 00:00:00