Abstract:
:Human platelets are less responsive to PAF at 37 degrees than at 25 degrees. They can be desensitized to the effects of PAF by pre-exposure to small concentrations. In both cases desensitization appears to be accompanied by a decreased affinity of the high affinity site for PAF rather than loss of binding sites. Alteration of a metabolic step subsequent to binding cannot be excluded, but platelets show normal response to a variety of other agents under the conditions resulting in desensitization of platelets to PAF.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Chesney CM,Pifer DD,Huch KMdoi
10.1016/s0006-291x(85)80120-0subject
Has Abstractpub_date
1985-02-28 00:00:00pages
24-30issue
1eissn
0006-291Xissn
1090-2104pii
S0006-291X(85)80120-0journal_volume
127pub_type
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