Desensitization of human platelets by platelet activating factor.

Abstract:

:Human platelets are less responsive to PAF at 37 degrees than at 25 degrees. They can be desensitized to the effects of PAF by pre-exposure to small concentrations. In both cases desensitization appears to be accompanied by a decreased affinity of the high affinity site for PAF rather than loss of binding sites. Alteration of a metabolic step subsequent to binding cannot be excluded, but platelets show normal response to a variety of other agents under the conditions resulting in desensitization of platelets to PAF.

authors

Chesney CM,Pifer DD,Huch KM

doi

10.1016/s0006-291x(85)80120-0

subject

Has Abstract

pub_date

1985-02-28 00:00:00

pages

24-30

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(85)80120-0

journal_volume

127

pub_type

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