Transforming growth factor-beta inhibits endothelial cell proliferation.

abstract：:The polycystic kidney disease (PKD) 1L3-PKD2L1 channel is a candidate sour taste receptor expressed in mammalian taste receptor cells. Various acids are reported to activate PKD channels after the removal of the acid stimuli, but little information is available on the activation of these channels by acetic acid. It wa...

journal_title：Biochemical and biophysical research communications

authors： Ishii S,Misaka T,Kishi M,Kaga T,Ishimaru Y,Abe K

更新日期：2009-07-31 00:00:00

abstract：:We examined the affinity of transthyretin (TTR) for lipoproteins and the effect of lipoproteins on TTR-related amyloidogenesis using serum samples from healthy volunteers and patients with familial amyloidotic polyneuropathy (FAP) ATTRVal30Met. In both volunteers and patients, TTR levels were highest in the VLDL fract...

journal_title：Biochemical and biophysical research communications

authors： Sun X,Ando Y,Haraoka K,Katsuragi S,Yamashita T,Yamashita S,Okajima M,Terazaki H,Okabe H

更新日期：2003-11-14 00:00:00

abstract：:In platelets, activation of protein kinase C and mobilization of Ca2+ were selectively induced by the addition of 1-oleoyl-2-acetyl-glycerol and a low concentration of A23187, respectively (Kaibuchi, K., Takai, Y., Sawamura, M., Hoshijima, M., Fujikura, T. and Nishizuka, Y. (1983) J. Biol. Chem. 258, 6701-6704). Using...

journal_title：Biochemical and biophysical research communications

authors： Kajikawa N,Kaibuchi K,Matsubara T,Kikkawa U,Takai Y,Nishizuka Y,Itoh K,Tomioka C

更新日期：1983-10-31 00:00:00

abstract：:Emerging evidences suggest that transcription-independent mechanism of p53 appears to make an important contribution to the overall p53-dependent apoptosis. Recently, it has been postulated that the DNA-binding domain of p53 can interact with Bcl-Xl, and subsequently the proposed molecular interaction has been shown b...

journal_title：Biochemical and biophysical research communications

authors： Xu H,Tai J,Ye H,Kang CB,Yoon HS

更新日期：2006-03-24 00:00:00

abstract：:Although proteins are generally composed of l-alpha-amino acids, biologically uncommon D-beta-aspartic acid (Asp)-containing proteins have been reported in various tissues from elderly individuals. Our previous study indicated that the N/N1003A cell line, derived from rabbit lens, includes D-beta-Asp-containing protei...

journal_title：Biochemical and biophysical research communications

authors： Takata T,Shimo-Oka T,Miki K,Fujii N

更新日期：2005-09-09 00:00:00

abstract：:Interest in lipoamino acids as endogenous modulators of G-protein coupled receptors has escalated due to their involvement in a variety of physiologic processes. In particular, a role for these amino acid conjugates has emerged in the endocannabinoid system. The study presented herein investigated the effects of N-ara...

journal_title：Biochemical and biophysical research communications

authors： Console-Bram L,Ciuciu SM,Zhao P,Zipkin RE,Brailoiu E,Abood ME

更新日期：2017-09-02 00:00:00

abstract：:Telmisartan, an angiotensin II type 1 receptor blocker (ARB), attenuates hyperglycemia-aggravated vascular inflammation by decreasing IκB kinase β (IKKβ) expression in endothelial cells. Because glycogen synthase 3β (GSK3β) is involved in inflammatory process by regulating nuclear factor-κB (NF-κB) activity, we invest...

journal_title：Biochemical and biophysical research communications

authors： Song KH,Bae SJ,Chang J,Park JH,Jo I,Cho KW,Cho DH

更新日期：2017-09-30 00:00:00

abstract：:It is well known that some intestinal bacteria, such as Escherichia coli, can produce a remarkable amount of molecular hydrogen (H(2)). Although the antioxidant effects of H(2) are well documented, the present study examined whether H(2) released from intestinally colonized bacteria could affect Concanavalin A (ConA)-...

journal_title：Biochemical and biophysical research communications

authors： Kajiya M,Sato K,Silva MJ,Ouhara K,Do PM,Shanmugam KT,Kawai T

更新日期：2009-08-21 00:00:00

abstract：:Ventricular septal defect (VSD) accounts for the largest number of birth congenital heart defects in human, but the genetic programs that control ventricular septation are poorly understood. To identify differentially expressed genes between ventricular septal defect and normal ventricular septum myocardium, we have u...

journal_title：Biochemical and biophysical research communications

authors： Zhang H,Zhou L,Yang R,Sheng Y,Sun W,Kong X,Cao K

更新日期：2006-03-31 00:00:00

abstract：:Antisense activity in living cells has been thought to occur via a mechanism involving both DNA-mediated hybridization arrest of target mRNA and RNase H-mediated mRNA digestion. Therefore an ideal antisense agent should be permeable to the cell and possess capacities (1) to form a thermally stable duplex in vivo with ...

journal_title：Biochemical and biophysical research communications

authors： Matsukura M,Okamoto T,Miike T,Sawai H,Shinozuka K

更新日期：2002-05-24 00:00:00

abstract：:Focal adhesion kinase (FAK) and integrin-linked kinase (ILK) are both involved in integrin-mediated cell migration. However, the molecular mechanism, and the relationship between FAK and ILK activity in signaling transduction for the osteopontin (OPN)-induced migration of vascular smooth muscle cells (VSMCs) remain un...

journal_title：Biochemical and biophysical research communications

authors： Li JJ,Han M,Wen JK,Li AY

更新日期：2007-04-27 00:00:00

abstract：:Recent evidence suggested that human cardiac stem cells (hCSCs) may have the clinical application for cardiac repair; however, their characteristics and the regulatory mechanisms of their growth have not been fully investigated. Here, we show the novel property of hCSCs with respect to their origin and tissue distribu...

journal_title：Biochemical and biophysical research communications

authors： Tateishi K,Ashihara E,Honsho S,Takehara N,Nomura T,Takahashi T,Ueyama T,Yamagishi M,Yaku H,Matsubara H,Oh H

更新日期：2007-01-19 00:00:00

abstract：:GlnR has been characterized as a central regulator governing most nitrogen metabolisms in many important actinomycetes. So far, the GlnR binding consensus sequences have been extensively studied, but with different motifs proposed, which has therefore brought confusion and impeded the understanding of the in-depth mol...

journal_title：Biochemical and biophysical research communications

authors： Wang J,Wang Y,Zhao GP

更新日期：2015-03-13 00:00:00

abstract：:The effects of the serine/threonine phosphatase inhibitors calyculin A, okadaic acid and the calmodulin antagonist W-7 on amylase secretion were studied in pancreatic acini. Calyculin A and okadaic acid dose-dependently inhibited amylase secretion to basal levels when stimulated with the intracellularly acting secreta...

journal_title：Biochemical and biophysical research communications

authors： Meyer-Alber A,Fetz I,Waschulewski IH,Höcker M,Fölsch UR,Schmidt WE

更新日期：1994-06-30 00:00:00

abstract：:This study was undertaken to interrogate cancer cell survival during long-term hypoxic stress. Two systems with relevance to carcinogenesis were employed: Fully transformed BJ cells and a renal carcinoma cell line (786-0). The dynamic of AMPK activity was consistent with a prosurvival role during chronic hypoxia. This...

journal_title：Biochemical and biophysical research communications

authors： Borger DR,Gavrilescu LC,Bucur MC,Ivan M,Decaprio JA

更新日期：2008-05-30 00:00:00

abstract：:mRNA levels of mitogen-activated protein kinase phosphatases, MKP-1 and MKP-2, were determined during chemical hepatocarcinogenesis and during regeneration of rat liver. In chemical hepatocarcinogenesis, the mRNA levels of MKP-1 were increased in primary hepatomas but decreased in rat ascites hepatomas as compared wit...

journal_title：Biochemical and biophysical research communications

authors： Yokoyama A,Karasaki H,Urushibara N,Nomoto K,Imai Y,Nakamura K,Mizuno Y,Ogawa K,Kikuchi K

更新日期：1997-10-29 00:00:00

abstract：:The RNA binding proteins (RBPs) have multiple roles in human cancer. However, their molecular target and function have not been clearly identified. Our genomic analysis derived from patients reveals that NONO is a potential oncogenic gene in lung cancer. NONO is highly expressed in lung cancer tissues compared with no...

journal_title：Biochemical and biophysical research communications

authors： Kim SJ,Ju JS,Park SS,Suh YA,Yoo HJ,Choi EK,Seong-Yun Jeong,Shin Y,Park YY

更新日期：2020-07-23 00:00:00

abstract：:This investigation is aimed to determine whether the biosynthesis of H(2)S, an endogenous vasodilator gas, is altered in the streptozotocin-diabetic rat. Plasma H(2)S concentration as well as the activity, and expression, of H(2)S synthesizing enzymes (namely cystathionine-gamma-lyase (CSE) and cystathionine-beta-synt...

journal_title：Biochemical and biophysical research communications

authors： Yusuf M,Kwong Huat BT,Hsu A,Whiteman M,Bhatia M,Moore PK

更新日期：2005-08-12 00:00:00

abstract：:The expression of mouse CYP27B1 in Escherichia coli has been dramatically enhanced by coexpression of GroEL/ES. To reveal the enzymatic properties of CYP27B1, we measured its hydroxylation activity toward vitamin D3 and 1alpha-hydroxyvitamin D3 (1alpha(OH)D3) in addition to the physiological substrate 25(OH)D3. Surpri...

journal_title：Biochemical and biophysical research communications

authors： Uchida E,Kagawa N,Sakaki T,Urushino N,Sawada N,Kamakura M,Ohta M,Kato S,Inouye K

更新日期：2004-10-15 00:00:00

abstract：:We have reported that the principal neutralizing domain of V3 of the HIV-1 gp120 induces an antigen-specific activation apoptosis of responding effector CD4+ T lymphocytes, a phenomenon inhibited by RANTES, an agonist of CCR5. Here, addressing the question of how a hypervariable region could induce such a selective re...

journal_title：Biochemical and biophysical research communications

authors： Baritaki S,Zafiropoulos A,Sioumpara M,Politis M,Spandidos DA,Krambovitis E

更新日期：2002-11-08 00:00:00

abstract：:Post-translational modification (PTM) of proteins plays a crucial role in health and disease by affecting numerous aspects of protein structure, function, stability and subcellular localization. Protein S-nitrosylation is one type of PTM that involves the covalent modification of cysteine sulfhydryl groups with nitric...

journal_title：Biochemical and biophysical research communications

authors： Khatib S,Artoul F,Gershko M,Markman G,Vaya J

更新日期：2014-02-14 00:00:00

abstract：:Four small ubiquitin-related modifier (SUMO) genes have been identified in humans. However, little is known about the basic biology of SUMO-4. Here, we report that SUMO-4 differs from SUMO-1, -2, and -3 in that the maturation process of SUMO-4 to active form containing C-terminal di-glycine residues is inhibited by a ...

journal_title：Biochemical and biophysical research communications

authors： Owerbach D,McKay EM,Yeh ET,Gabbay KH,Bohren KM

更新日期：2005-11-18 00:00:00

abstract：:Metallosphaera sedula is a thermoacidophilic autotrophic archaeon and known to utilize the 3-hydroxypropionate/4-hydroxybutyrate cycle (3-HP/4-HB cycle) as a carbon fixation pathway. The 3-HP/4-HB cycle in M. sedula is associated with central metabolism, and malate dehydrogenase (MDH) is an enzyme involved in the cent...

journal_title：Biochemical and biophysical research communications

authors： Lee D,Hong J,Kim KJ

更新日期：2019-02-12 00:00:00

abstract：:Recent advances in cancer biology reveal the importance of metabolic changes in cancer; however, less is known about how metabolic pathways in tumors are regulated in vivo. Here, we report analysis of the lung cancer metabolism based on different surgical procedures, namely lobectomy and partial resection. In lobectom...

journal_title：Biochemical and biophysical research communications

authors： Kikuchi N,Soga T,Nomura M,Sato T,Sakamoto Y,Tanaka R,Abe J,Morita M,Shima H,Okada Y,Tanuma N

更新日期：2020-09-10 00:00:00

abstract：:Two forms of human placental alkaline phosphatase have been purified to homogeneity utilizing high performance liquid chromatography. Both have the same amino acid composition but they differ in their carbohydrate substituents. Sequence data indicate that the two forms are identical for the first forty two residues fr...

journal_title：Biochemical and biophysical research communications

authors： Ezra E,Blacher R,Udenfriend S

更新日期：1983-11-15 00:00:00

abstract：:Abnormally expressed long noncoding RNAs (lncRNAs) has been recognized as one of the key source in cardiac diseases. However, the role of lncRNA in doxorubicin (DOX)-induced cardiotoxicity remains largely unknown. In previous studies, we have screened some aberrantly expressed lncRNAs from an animal model for DOX-indu...

journal_title：Biochemical and biophysical research communications

authors： Li J,Li L,Li X,Wu S

更新日期：2018-09-18 00:00:00

abstract：:Interleukin 6 is a cytokine with growth and differentiation activities on a number of cell types. Human articular chondrocytes produce interleukin 6 and this production appears to be constitutive but can be stimulated in a dose-dependent manner by interleukin 1. Other stimulators of interleukin 6 production in chondro...

journal_title：Biochemical and biophysical research communications

authors： Bunning RA,Russell RG,Van Damme J

更新日期：1990-02-14 00:00:00

abstract：:Ubiquitin specific protease 39 (USP39) is one of the deubiquitinating enzymes without ubiquitin protease activity, which has been implicated in the progression of several cancers. However, the role of USP39 in pancreatic cancer (PC) is largely unknown. In present study, we found that USP39 expression was elevated in P...

journal_title：Biochemical and biophysical research communications

authors： Cai J,Liu T,Huang P,Yan W,Guo C,Xiong L,Liu A

更新日期：2017-04-22 00:00:00

abstract：:Diacylglycerol kinase (DGK) plays an important role in phosphoinositide signaling cascade by regulating the intracellular level of diacylglycerol and phosphatidic acid. The DGK family is involved in various pathophysiological responses that are mediated through unique binding partners in different tissues and cells. I...

journal_title：Biochemical and biophysical research communications

authors： Okada M,Hozumi Y,Iwazaki K,Misaki K,Yanagida M,Araki Y,Watanabe T,Yagisawa H,Topham MK,Kaibuchi K,Goto K

更新日期：2012-04-06 00:00:00

abstract：:The Bcl-2 oncoprotein is a potent inhibitor of apoptosis and is overexpressed in a variety of different malignancies. Bcl-2 function is regulated through heterodimerization with other members of the Bcl-2 protein family. In addition, several proteins that are not members of the Bcl-2 family can bind to Bcl-2, includin...

journal_title：Biochemical and biophysical research communications

authors： Antoku K,Maser RS,Scully WJ Jr,Delach SM,Johnson DE

更新日期：2001-09-07 00:00:00