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An RNA-binding-protein, NONO governs energy metabolism by regulating NAMPT in lung cancer.

Abstract：

:The RNA binding proteins (RBPs) have multiple roles in human cancer. However, their molecular target and function have not been clearly identified. Our genomic analysis derived from patients reveals that NONO is a potential oncogenic gene in lung cancer. NONO is highly expressed in lung cancer tissues compared with normal tissues, and its expression has been correlated with the prognosis of lung cancer patients. We found that NONO significantly influences cancer cell proliferation in lung cancer. Gene expression profiles with NONO-depleted cells revealed that the sirtuin signaling pathway is highly correlated with NONO. Thus, NONO-silenced cells caused reduction of the TCA cycle and glycolysis metabolism. We identified that NONO regulated NAMPT, which is a well-known gene involved in sirtuin signaling, and NONO has a significant correlation with NAMPT in lung cancer patients. We propose that NONO modulates energy metabolism by direct interaction with NAMPT and suggest that a functional relationship between NONO and NAMPT contributes to lung cancer cell survival. Targeting the axis can be a promising approach for patient treatment in lung cancer.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Kim SJ,Ju JS,Park SS,Suh YA,Yoo HJ,Choi EK,Seong-Yun Jeong,Shin Y,Park YY

doi

10.1016/j.bbrc.2020.01.011

subject

Has Abstract

pub_date

2020-07-23 00:00:00

pages

376-382

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(20)30028-0

journal_volume

528

pub_type

杂志文章

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