Characterization of new D-beta-aspartate-containing proteins in a lens-derived cell line.

abstract：:The ontogeny of the cytosolic receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin was studied in Sprague-Dawley rats by quantitation of the receptor in hepatic, lung, and thymic cytosol. Concentrations of hepatic and lung cytosolic receptors increased rapidly after birth and remained at the highest levels from days 2 to ...

journal_title：Biochemical and biophysical research communications

authors： Gasiewicz TA,Ness WC,Rucci G

更新日期：1984-01-13 00:00:00

abstract：:The AML1 gene encodes DNA-binding proteins that contain the Runt domain and is found at the breakpoints of some translocations associated with leukemias. It has been reported that AML1 plays pivotal roles in myeloid differentiation, probably through the transcriptional regulation of various hematopoietic genes. Here w...

journal_title：Biochemical and biophysical research communications

authors： Imai Y,Kurokawa M,Tanaka K,Friedman AD,Ogawa S,Mitani K,Yazaki Y,Hirai H

更新日期：1998-11-27 00:00:00

abstract：:The maintenance of telomere length is crucial for survival of cells. Telomerase is an RNA-containing reverse transcriptase, which is responsible for elongation of shortened telomeres. Telomerase reactivation has been suggested to be involved in malignant progressions. To study on the involvement of telomerase activati...

journal_title：Biochemical and biophysical research communications

authors： Miura M,Karasaki Y,Abe T,Higashi K,Ikemura K,Gotoh S

更新日期：1998-05-08 00:00:00

abstract：:A common peptide motif has been discovered among a series of Golgi-localized glycosyltransferases. The peptide stretch, (Ser/Thr)-X-(Glu/Gln)-(Arg/Lys), always occurs near a hydrophobic domain close to the N-terminus of these enzymes which is believed to anchor them to the membrane lipid bilayer (Paulson and Colley, J...

journal_title：Biochemical and biophysical research communications

authors： Bendiak B

更新日期：1990-07-31 00:00:00

abstract：:Differences in insulin-like growth factor binding proteins (IGFBPs) expressed within estrogen receptor positive (ER+, MCF-7/6) and negative (ER-, MDA-MB-231) human breast cancer cells cultured in chemically defined medium were observed. In the absence of insulin, 17 beta-estradiol affects this expression in ER+ cells ...

journal_title：Biochemical and biophysical research communications

authors： Dubois V,Couissi D,Schonne E,Schneider YJ,Remacle C,Trouet A

更新日期：1993-04-15 00:00:00

abstract：:Mouse mammary carcinoma mutant cell line FUA169, characterized by high GM3 ganglioside content, was established from parent cell line FM3A/F28-7, which has high LacCer content but no GM3. Although both cell lines showed the same quantity and quality of integrin receptors, FUA169 showed much stronger adhesion to fibron...

journal_title：Biochemical and biophysical research communications

authors： Zheng M,Tsuruoka T,Tsuji T,Hakomori S

更新日期：1992-08-14 00:00:00

abstract：:Uncoupling proteins (UCPs) are mitochondrial membrane proton transporters that uncouple oxidative phosphorylation by dissipating the proton gradient across the membrane. We have investigated regulation of the UCP3 gene in skeletal muscle and C2C12 muscle cells. UCP3 mRNA in mouse skeletal muscle is markedly increased ...

journal_title：Biochemical and biophysical research communications

authors： Hwang CS,Lane MD

更新日期：1999-05-10 00:00:00

abstract：:Terminal Schwann cells (TSCs) that cover motor neuron terminals are known to play important roles in maintaining neuromuscular junctions, as well as in the repair process after nerve injury. However, molecular characteristics of TSCs remain unknown, because of the difficulties in analyzing them due to their paucity. W...

journal_title：Biochemical and biophysical research communications

authors： Oda R,Yaoi T,Okajima S,Kobashi H,Kubo T,Fushiki S

更新日期：2003-09-05 00:00:00

abstract：:In this study, we assessed the profile of cell proliferation, Na,K-ATPase activity and apoptosis in primary cultures of proximal tubule cells. Freshly isolated proximal tubules exhibited apoptosis very early in culture: floated cells within 6 hr; attached tubule cells within 20 hr. The onset of apoptosis in either att...

journal_title：Biochemical and biophysical research communications

authors： Tang MJ,Cheng YR,Lin HH

更新日期：1996-01-26 00:00:00

abstract：:Genome editing technology using programmable nucleases has rapidly evolved in recent years. The primary mechanism to achieve precise integration of a transgene is mainly based on homology-directed repair (HDR). However, an HDR-based genome-editing approach is less efficient than non-homologous end-joining (NHEJ). Rece...

journal_title：Biochemical and biophysical research communications

authors： Shin JH,Jung S,Ramakrishna S,Kim HH,Lee J

更新日期：2018-07-07 00:00:00

abstract：:Viral mRNA encoding vesicular stomatitis virus glycoprotein sequences was detected and quantitated using a DNA-hybridization dot-blot technique. This assay was employed to determine if the synthetic double-stranded polynucleotide complex of polyriboinosinic-polyribocytidylic acid would elicit viral resistance in vitro...

journal_title：Biochemical and biophysical research communications

authors： Thomson MS,Bird RC,Stringfellow DA,Rossi CR,Lauerman LH

更新日期：1991-02-28 00:00:00

abstract：:Actions of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on all-trans-retinoic acid (trans-RA) binding to retinoic acid receptors (RARs) in cultured human keratinocytes (SCC-12F) was investigated. TCDD and trans-RA elicited opposing actions on the production of biologically active TGF-beta. TCDD exposure caused concentra...

journal_title：Biochemical and biophysical research communications

authors： Lorick KL,Toscano DL,Toscano WA Jr

更新日期：1998-02-24 00:00:00

abstract：:Osteoclast activity is enhanced in acidic environments following systemic or local inflammation. However, the regulatory mechanism of receptor activator of NF-κB ligand (RANKL) expression in osteoblasts under acidic conditions is not fully understood. In the present paper, we detected the mRNA expression of the G-prot...

journal_title：Biochemical and biophysical research communications

authors： Okito A,Nakahama K,Akiyama M,Ono T,Morita I

更新日期：2015-03-06 00:00:00

abstract：:Leptin and its receptors are overexpressed in breast cancer tissues and correlate with poor prognosis. Survivin, a member of the inhibitor of apoptosis protein (IAP) gene family, is generally upregulated in tumor tissues and prevents tumor cells from apoptosis. Here we showed that leptin upregulated survivin mRNA and ...

journal_title：Biochemical and biophysical research communications

authors： Jiang H,Yu J,Guo H,Song H,Chen S

更新日期：2008-03-28 00:00:00

abstract：:We screened various isoprenoids to search for inducers of apoptosis-like cell death ("apoptosis") in the shoot primordia of Matricaria chamomilla and found that geraniol has the most potent apoptosis-inducing activity among terpenoids, as judged from DNA fragmentation in the cells. The apoptosis-inducing activity of g...

journal_title：Biochemical and biophysical research communications

authors： Izumi S,Takashima O,Hirata T

更新日期：1999-06-16 00:00:00

abstract：:Although the flexural rigidity of a microtubule has previously been estimated by various methods, its temperature dependence has never been systematically examined. Here, we measured the flexural rigidity of a single taxol-stabilized microtubule from thermal fluctuation of the free end of a microtubule, the other end ...

journal_title：Biochemical and biophysical research communications

authors： Kawaguchi K,Ishiwata S,Yamashita T

更新日期：2008-02-15 00:00:00

abstract：:Oxidative stress is known to play a pivotal role in the development of oral squamous cell carcinoma (OSCC). We have demonstrated that activation of the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway has chemopreventive effects against oxidative stress-associated OSCC. However, Nrf2 have dual role...

journal_title：Biochemical and biophysical research communications

authors： Fan H,Paiboonrungruan C,Zhang X,Prigge JR,Schmidt EE,Sun Z,Chen X

更新日期：2017-11-04 00:00:00

abstract：:2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related compounds modulate various endocrine functions by enhancing ligand metabolism, altering hormone synthesis, down regulating receptor levels, and interfering with gene transcription. In the present study, we investigated the effects of TCDD on testosterone signal tr...

journal_title：Biochemical and biophysical research communications

authors： Jana NR,Sarkar S,Ishizuka M,Yonemoto J,Tohyama C,Sone H

更新日期：1999-03-24 00:00:00

abstract：:We herein report two new genes, human neugrin and mouse homologue m-neugrin, found by screening the cDNA library for the human spinal cord. The neugrin mRNA encodes 219 amino acids and its deduced amino acid sequence contains an NLS-like domain. No previously known motif is found in it. m-neugrin mRNA encodes 233 amin...

journal_title：Biochemical and biophysical research communications

authors： Ishigaki S,Niwa J,Yoshihara T,Mitsuma N,Doyu M,Sobue G

更新日期：2000-12-20 00:00:00

abstract：:Chronic myeloid leukemia (CML) responds well to BCR-ABL tyrosine kinase inhibitors (TKI), but becomes resistant to TKIs after it progresses to blast phase (BP). Here we show that niclosamide, a FDA-approved anthelmintic drug, enhances the sensitivity of BP-CML cells to dasatinib (2nd generation of BCR-ABL TKI) through...

journal_title：Biochemical and biophysical research communications

authors： Liu Z,Li Y,Lv C,Wang L,Song H

更新日期：2016-09-16 00:00:00

abstract：:Lysinuric protein intolerance (LPI; MIM 222700) is an autosomal recessive disorder characterized by defective transport of cationic amino acids lysine, arginine and ornithine. The defect is localized in the basolateral membrane of polar epithelial cells of the renal tubules and intestine. The SLC7A7 (solute carrier fa...

journal_title：Biochemical and biophysical research communications

authors： Toivonen M,Mykkänen J,Aula P,Simell O,Savontaus ML,Huoponen K

更新日期：2002-03-15 00:00:00

abstract：:The alpha(1c) subunit of the cardiac L-type Ca(2+) channel, which contains the channel pore, voltage- and Ca(2+)-dependent gating structures, and drug binding sites, has been well studied in heterologous expression systems, but many aspects of L-type Ca(2+) channel behavior in intact cardiomyocytes remain poorly chara...

journal_title：Biochemical and biophysical research communications

authors： Ganesan AN,O'Rourke B,Maack C,Colecraft H,Sidor A,Johns DC

更新日期：2005-04-08 00:00:00

abstract：:Dietary phosphate restriction produces an adaptive increase in renal tubular Na/Pi cotransport. A similar adaptation occurs during phosphate depletion in opossum kidney cells, a continuous line of cultured renal epithelial cells. We investigated the cellular changes associated with adaptation to phosphate depletion in...

journal_title：Biochemical and biophysical research communications

authors： Saxena S,Dansby L,Allon M

更新日期：1995-11-02 00:00:00

abstract：:MicroRNA (miRNA) plays a pivotal role in cancer biology. Therefore, tumor suppressor (TS) miRNAs are an attractive target for cancer therapy. However, clinical trials have failed due to the difficulties in miRNA delivery, warranting the development of a novel drug delivery system (DDS). Exosomes are stable in circulat...

journal_title：Biochemical and biophysical research communications

authors： Kobayashi M,Sawada K,Miyamoto M,Shimizu A,Yamamoto M,Kinose Y,Nakamura K,Kawano M,Kodama M,Hashimoto K,Kimura T

更新日期：2020-06-18 00:00:00

abstract：:The transcription of human nm23 genes (nm23-H1, nm23-H2) is involved in suppression of tumor metastasis or tumor progression. Therefore the characterization of transcriptional regulatory mechanisms for both nm23 genes is very important. In this study we have isolated and analyzed the 5'-flanking region of the human nm...

journal_title：Biochemical and biophysical research communications

authors： Seifert M,Seib T,Engel M,Dooley S,Welter C

更新日期：1995-10-24 00:00:00

abstract：:Mammary epithelial cells derived from the entire mammary parenchyma or only end buds were isolated by collagenase digestion of mammary glands from virgin mice. Cells were cultured within collagen gels in serum-free medium containing insulin. Keratinocyte growth factor (KGF or FGF-7) and acidic fibroblast growth factor...

journal_title：Biochemical and biophysical research communications

authors： Imagawa W,Cunha GR,Young P,Nandi S

更新日期：1994-11-15 00:00:00

abstract：:Loaded under whole cell patch-clamp configuration, the caged Ca2+ molecule DM-nitrophen was used to increase [Ca2+]i rapidly and reversibly in isolated Deiters cells of the organ of Corti. Photolysis of DM-nitrophen increased [Ca2+]i from resting concentrations of 20-50 nM to values above microM, as measured with the ...

journal_title：Biochemical and biophysical research communications

authors： Dulon D,Blanchet C,Laffon E

更新日期：1994-06-30 00:00:00

abstract：:Midkine (MK) is a novel growth factor and is the product of a retinoic acid responsive gene. When P19 murine embryonal carcinoma (EC) cells were exposed to MK, they differentiated into neurons, and the neuronal differentiation was accompanied by expression of choline acetyltransferase activity. Synthesis and release o...

journal_title：Biochemical and biophysical research communications

authors： Michikawa M,Xu RY,Muramatsu H,Muramatsu T,Kim SU

更新日期：1993-05-14 00:00:00

abstract：:Oxygen exchange between high-valent metal-oxo complexes and bulk water has been monitored for nonligated model porphyrins (hemin, FeTDCPPS, MnTMPyP) and the axially ligated microperoxidase-8 (MP-8). Exchange extents up to 90% were measured for MP-8 in spite of the presence of an axial histidine ligand and accompanied ...

journal_title：Biochemical and biophysical research communications

authors： Primus JL,Teunis K,Mandon D,Veeger C,Rietjens IM

更新日期：2000-06-07 00:00:00

abstract：:Various dehydrogenation polymers (the so-called synthetic lignins) were synthesized from four different phenylpropenoids by endwise and bulk polymerizations and investigated for their anti-influenza virus activity. All of these materials suppressed the plaque formation of influenza virus infecting MDCK cells and the R...

journal_title：Biochemical and biophysical research communications

authors： Sakagami H,Nagata K,Ishihama A,Oh-hara T,Kawazoe Y

更新日期：1990-11-15 00:00:00