A possible role of protein kinase C in signal-induced lysosomal enzyme release.

abstract：:We have isolated a rabbit metallothionein-I gene from a lambda gt10 library. The coding sequence of this gene is interrupted by two introns occurring at amino acid positions 9 1/3 and 30 1/3. Comparison of the promoter sequence of this gene with the promoters of other metallothionein genes identified a number of oligo...

journal_title：Biochemical and biophysical research communications

authors： Tam YC,Chopra A,Hassan M,Thirion JP

更新日期：1988-05-31 00:00:00

abstract：:Blockading the negative-regulatory CTLA-4 receptor has emerged as a powerful strategy with clinical potential to enhance T-cell responses. Some experimental tumors, for example, are rejected when anti-CTLA-4 antibodies are administered in vivo. The concise target cells and downstream events, however, remain to be defi...

journal_title：Biochemical and biophysical research communications

authors： Cepero E,Hnatyszyn HJ,Kraus G,Lichtenheld MG

更新日期：1998-06-29 00:00:00

abstract：:The estrogen receptor (ER) is a ligand-dependent transcription factor which regulates growth, development, differentiation and reproduction. To test the hypothesis that the diverse effects of the ER could be mediated by interacting with other transcription factors/oncogenes, the present study assessed its interaction ...

journal_title：Biochemical and biophysical research communications

authors： Yu CL,Driggers P,Barrera-Hernandez G,Nunez SB,Segars JH,Cheng S

更新日期：1997-10-20 00:00:00

abstract：:The process in which nucleotide is buried into the active site of heavy meromyosin was studied with stopped-flow apparatus by monitoring the time-course of the large fluorescence increase of 1,N6-ethenoadenosine triphosphate (epsilon-ATP) when it binds from acrylamide-containing solutions. We have recently reported th...

journal_title：Biochemical and biophysical research communications

authors： Ando T,Duke JA

更新日期：1983-08-30 00:00:00

abstract：:Nitrogen heterocycle small molecules display various pharmaceutically important bioactivities and have great potential in drug development and application. Microbes are an important source for discovering nitrogen heterocycle natural products, and the elucidation of their biosynthetic pathways in microbes facilitates ...

journal_title：Biochemical and biophysical research communications

authors： Chai S,Cao M,Feng Z

更新日期：2021-01-11 00:00:00

abstract：:Hereditary multiple exostoses (EXT) is an autosomal dominant disorder that is characterized by the appearance of multiple outgrowths of the long bones (exostoses) at their epiphyses. Genetical heterogeneities have segregated at least on chromosome 8, 11, and 19 and been designated EXT1, EXT2, and EXT3, respectively. R...

journal_title：Biochemical and biophysical research communications

authors： Saito T,Seki N,Yamauchi M,Tsuji S,Hayashi A,Kozuma S,Hori T

更新日期：1998-02-04 00:00:00

abstract：:Long repeated stretches of d(CCG) and tri-nucleotide are crucial mutations that cause hereditary forms of mental retardation (fragile X-syndrome). Moreover, the alternating (CG) di-nucleotide is one of the candidates for Z-DNA conformation. Solution NMR structure of d(CCGCGG)(2) has been solved and is discussed. The d...

journal_title：Biochemical and biophysical research communications

authors： Monleón D,Esteve V,Celda B

更新日期：2003-03-28 00:00:00

abstract：:Rbx1 and Rbx2 are essential components of Cullin-RING E3 Ligases. Vif is generally believed to preferentially recruit the Cul5-Rbx2 module to induce proteasomal degradation of antiretroviral enzyme APOBEC3G, although some investigators have found that the Cul5-Rbx1 module is recruited. Here, to investigate the functio...

journal_title：Biochemical and biophysical research communications

authors： Wang X,Wang X,Wang W,Zhang J,Wang J,Wang C,Lv M,Zuo T,Liu D,Zhang H,Wu J,Yu B,Kong W,Wu H,Yu X

更新日期：2015-06-12 00:00:00

abstract：:The cis-regulatory region of target genes is key elements in the transcriptional regulation of gene expression. Many of these cis-regulatory regions have not been identified by either biological experiments or computational methods. Recently, a few additional C(2)H(2) zinc finger transcription factor binding sites hav...

journal_title：Biochemical and biophysical research communications

authors： Cho SY,Chung M,Park M,Park S,Lee YS

更新日期：2008-05-09 00:00:00

abstract：:The glycolytic inhibitor 2-deoxy-d-glucose (2DG) causes energy starvation, affecting cell viability in a wide range of cancer cell lines. To determine the action of 2DG in pancreatic cancer, we performed proteomic analysis of pancreatic cancer cell line after 2DG treatment. Eighty proteins showed differential expressi...

journal_title：Biochemical and biophysical research communications

authors： Ishino K,Kudo M,Peng WX,Kure S,Kawahara K,Teduka K,Kawamoto Y,Kitamura T,Fujii T,Yamamoto T,Wada R,Naito Z

更新日期：2018-06-27 00:00:00

abstract：:SPE-16 is a new 16kDa protein that has been purified from the seeds of Pachyrrhizus erosus. It's N-terminal amino acid sequence shows significant sequence homology to pathogenesis-related class 10 proteins. cDNA encoding 150 amino acids was cloned by RT-PCR and the gene sequence proved SPE-16 to be a new member of PR-...

journal_title：Biochemical and biophysical research communications

authors： Wu F,Yan M,Li Y,Chang S,Song X,Zhou Z,Gong W

更新日期：2003-12-19 00:00:00

abstract：:Mammalian target of rapamycin (mTOR) is a therapeutic target for head and neck squamous cell carcinoma (HNSCC). Here, we evaluated the activity of AZD-2014, a potent mTOR complex 1/2 (mTORC1/2) dual inhibitor, against HNSCC cells. We showed that AZD-2014 blocked mTORC1/2 activation in established and primary human HNS...

journal_title：Biochemical and biophysical research communications

authors： Li Y,Cui JT

更新日期：2016-09-02 00:00:00

abstract：:Male Djungarian hamsters (Phodopus sungorus; 45 animals per group) were either sham-exposed or exposed to a sinusoidal magnetic field for 56 days (Experiment 1: 50 Hz, 450 microTesla peak; max. dB/dt = 140 mTesla s(-1); 24 hrs day(-1)). Except for day 7, no effects were observed with respect to body weights during exp...

journal_title：Biochemical and biophysical research communications

authors： Niehaus M,Brüggemeyer H,Behre HM,Lerchl A

更新日期：1997-05-29 00:00:00

abstract：:Insulin resistance is a cardinal feature of Type 2 Diabetes (T2D), which accompanied by lipid accumulation and TNF-α overexpression in skeletal muscle. The role of TNF-α in palmitate-induced insulin resistance remained to be elucidated. Here, we assessed effects of TNF-α knockdown on the components of insulin signalin...

journal_title：Biochemical and biophysical research communications

authors： Haghani K,Pashaei S,Vakili S,Taheripak G,Bakhtiyari S

更新日期：2015-05-15 00:00:00

abstract：:The effect of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] on the growth of normal human keratinocytes cultured in serum-free medium was investigated. 1,25(OH)2D3 inhibited the cell growth at 10(-7) M by 75.3% and at 10(-6) M almost completely. The growth inhibition was accompanied by changes related to proliferation: (1) r...

journal_title：Biochemical and biophysical research communications

authors： Matsumoto K,Hashimoto K,Nishida Y,Hashiro M,Yoshikawa K

更新日期：1990-01-30 00:00:00

abstract：:Semicarbazide-sensitive amine oxidase (SSAO) activity in plasma is increased in diabetes, and in particular, in diabetic patients with vascular complications. It has been speculated that SSAO is involved in the development of such complications due to the production of cytotoxic compounds. In this work, we have induce...

journal_title：Biochemical and biophysical research communications

authors： Gokturk C,Nordquist J,Sugimoto H,Forsberg-Nilsson K,Nilsson J,Oreland L

更新日期：2004-12-17 00:00:00

abstract：:Idiopathic epilepsy is characterized by seizures without a clear etiology and is believed to have a strong genetic component but exhibits a complex inheritance pattern. Genetic factors seem to confer a low seizure threshold to susceptible individuals and thereby enhance epileptogenesis. However, the identity of suscep...

journal_title：Biochemical and biophysical research communications

authors： Bae YS,Chung W,Han K,Park KY,Kim H,Kim E,Kim MH

更新日期：2013-04-05 00:00:00

abstract：:Many methods have been developed for chemical labeling and enhancement of the properties of antibodies and their common fragments, including the Fab and F(ab')2 fragments. Somewhat selective reduction of some antibody disulfide bonds has been previously achieved, yielding antibodies and antibody fragments that can be ...

journal_title：Biochemical and biophysical research communications

authors： Kirley TL,Greis KD,Norman AB

更新日期：2016-11-25 00:00:00

abstract：:In vertebrate cells, DNA double-strand breaks are efficiently repaired by homologous recombination or nonhomologous end-joining (NHEJ). The latter pathway relies on Ku (the Ku70/Ku86 heterodimer), DNA-PKcs, Artemis, Xrcc4, and DNA ligase IV (Lig4). Here, we show that a human pre-B cell line nullizygous for Lig4 exhibi...

journal_title：Biochemical and biophysical research communications

authors： Adachi N,Iiizumi S,So S,Koyama H

更新日期：2004-06-11 00:00:00

abstract：:The relation between platelet-derived growth factor (PDGF)-induced smooth muscle cell migration, measured in Boyden chambers, and cellular arachidonic acid cascade was studied by using rat aortic smooth muscle cells. Partially purified PDGF stimulated cell migration significantly at a concentration of 1.33-133.0 micro...

journal_title：Biochemical and biophysical research communications

authors： Nakao J,Ito H,Chang WC,Koshihara Y,Murota S

更新日期：1983-05-16 00:00:00

abstract：:The cellular response to DNA damage induced by gamma-irradiation activates cell-cycle arrest to permit DNA repair and to prevent replication. Cyclin D1 is the key molecule for transition between the G1 and S phases of the cell-cycle, and amplification or overexpression of cyclin D1 plays pivotal roles in the developme...

journal_title：Biochemical and biophysical research communications

authors： Choo DW,Baek HJ,Motoyama N,Cho KH,Kim HS,Kim SS

更新日期：2009-01-23 00:00:00

abstract：:Loss-of-function mutations in the DJ-1/PARK7 gene are responsible for early-onset autosomal-recessive Parkinson's disease. DJ-1 is implicated in the protection of neurons from oxidative stress by scavenging hydrogen peroxide and regulating the transcriptional activity of multiple pathways. Here, we attempted to identi...

journal_title：Biochemical and biophysical research communications

authors： Kim SJ,Park YJ,Oh YJ

更新日期：2012-05-25 00:00:00

abstract：:The proteasome is a recently identified intracellular protease whose catalytic active site is a threonine residue and has been shown to play key roles in a variety of important intracellular events, including cell cycle progression, the antigen-presenting pathway, and apoptosis. However, its biological significance in...

journal_title：Biochemical and biophysical research communications

authors： Oikawa T,Sasaki T,Nakamura M,Shimamura M,Tanahashi N,Omura S,Tanaka K

更新日期：1998-05-08 00:00:00

abstract：:Antibody-based targeted therapy of cancers requires the antibody targeting of specific molecules inducing tumor cells apoptosis or death. Angiopoietin-2 (Agn-2) and translocator protein (TSPO) are identified as potential target molecules for glioblastoma therapy. The single chain anti-Agn-2 antibody (Anag-2) and anti-...

journal_title：Biochemical and biophysical research communications

authors： Li J,Zhang Z,Lv L,Qiao H,Chen X,Zou C

更新日期：2016-04-01 00:00:00

abstract：:MicroRNAs play important roles in the carcinogenesis of many types of cancers by inhibiting gene expression at posttranscriptional level. However, the roles of microRNAs in hepatocellular carcinoma, are still unclear. Here, we identified that miR-367 promotes hepatocellular carcinoma (HCC) cell proliferation by negati...

journal_title：Biochemical and biophysical research communications

authors： Meng X,Lu P,Fan Q

更新日期：2016-01-29 00:00:00

abstract：:N-Glycosylation has been shown to affect the rate of glycoprotein transport through the secretory pathway. In order to identify the critical components in the N-glycosylation pathway that directly influence protein secretion, we have studied the effects of downregulation of the first gene in the dolichol pathway, ALG7...

journal_title：Biochemical and biophysical research communications

authors： Kukuruzinska MA,Apekin V,Lamkin MS,Hiltz A,Rodriguez A,Lin CC,Paz MA,Oppenheim FG

更新日期：1994-02-15 00:00:00

abstract：:Insect midgut peritrophic membrane (PM) is a functional structure that protects insects against chemical damage and microorganism infection. The essential component in PM is chitin and its synthesis is catalyzed by Class B chitin synthase (CHSB), which plays a unique role in chitin-containing organisms and thus repres...

journal_title：Biochemical and biophysical research communications

authors： Qu M,Liu T,Yang J,Yang Q

更新日期：2011-01-07 00:00:00

abstract：:Systemic injections of AAV vectors generally transduce to the liver more effectively than to cardiac and skeletal muscles. The short hairpin RNA (shRNA)-expressing AAV9 (shRNA-AAV9) can also reduce target gene expression in the liver, but not enough in cardiac or skeletal muscles. Higher doses of shRNA-AAV9 required f...

journal_title：Biochemical and biophysical research communications

authors： Mayra A,Tomimitsu H,Kubodera T,Kobayashi M,Piao W,Sunaga F,Hirai Y,Shimada T,Mizusawa H,Yokota T

更新日期：2011-02-11 00:00:00

abstract：:Sensitization to Cupressaceae pollen has become one of the most important causes of pollinosis in Western countries during winter and early spring. However, the characterization of the extracts, the allergens involved and the cross-reactivity with other pollen sources still remain poorly studied; in the case of Cupres...

journal_title：Biochemical and biophysical research communications

authors： Pico de Coaña Y,Parody N,Fuertes MÁ,Carnés J,Roncarolo D,Ariano R,Sastre J,Mistrello G,Alonso C

更新日期：2010-10-22 00:00:00

abstract：:Although brain natriuretic peptide (BNP) is a novel natriuretic peptide originally identified in porcine brain, recent investigation has verified the presence of BNP in porcine heart. In order to identify BNP as a circulating hormone, we analyzed the regional distribution and molecular form of immunoreactive (ir-) BNP...

journal_title：Biochemical and biophysical research communications

authors： Aburaya M,Minamino N,Kangawa K,Tanaka K,Matsuo H

更新日期：1989-12-15 00:00:00