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Distribution and molecular forms of brain natriuretic peptide in porcine heart and blood.

Abstract：

:Although brain natriuretic peptide (BNP) is a novel natriuretic peptide originally identified in porcine brain, recent investigation has verified the presence of BNP in porcine heart. In order to identify BNP as a circulating hormone, we analyzed the regional distribution and molecular form of immunoreactive (ir-) BNP in heart and blood. Tissue concentration of ir-BNP was high in atrium, but low in ventricle, in a manner similar to that of atrial natriuretic peptide (ANP). However, the concentration of ir-BNP in atrium was only about 1/50 that of ir-ANP. In plasma, ir-BNP was found at a concentration of 1-3 fmol/ml, which was about 1/20 that of ir-ANP. Both ir-BNP and ir-ANP were present as low molecular weight forms. Three forms of ir-BNP of about 3K daltons, including BNP-26, BNP-29 and BNP-32, are thought to circulate in blood.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Aburaya M,Minamino N,Kangawa K,Tanaka K,Matsuo H

doi

10.1016/s0006-291x(89)80047-6

subject

Has Abstract

pub_date

1989-12-15 00:00:00

pages

872-9

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(89)80047-6

journal_volume

165

pub_type

杂志文章

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