当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Identification of differentially expressed genes in human heart with ventricular septal defect using suppression subtractive hybridization.

Identification of differentially expressed genes in human heart with ventricular septal defect using suppression subtractive hybridization.

Abstract：

:Ventricular septal defect (VSD) accounts for the largest number of birth congenital heart defects in human, but the genetic programs that control ventricular septation are poorly understood. To identify differentially expressed genes between ventricular septal defect and normal ventricular septum myocardium, we have undertaken suppression subtractive hybridization (SSH) and generated reciprocal cDNA collections of representative mRNAs specific to human heart with ventricular septal defect versus normal control. Following SSH, 1378 clones were sequenced and found to derive from 551 different genes. These predominately expressed genes included genes involved in energy metabolism, cell cycle and growth, cytoskeleton and cell adhesion, LIM protein, zinc finger protein, and development. It is anticipated that further study of genes identified will provide insights into their specific roles in the etiology of VSD, even in cardiac development, aging, and disease.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Zhang H,Zhou L,Yang R,Sheng Y,Sun W,Kong X,Cao K

doi

10.1016/j.bbrc.2006.01.113

subject

Has Abstract

pub_date

2006-03-31 00:00:00

pages

135-44

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(06)00203-8

journal_volume

342

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • Inhibitors of RNA and protein synthesis stabilize messenger RNA for the RII beta subunit of protein kinase A in different cellular compartments.

    abstract：:Messenger RNA for RII beta is transiently induced (greater than 50-fold) by cAMP analogs in primary cultures of rat Sertoli cells. The induction is dependent on protein synthesis. We have previously shown that mRNA for RII beta is stabilized by cAMP, as well as inhibitors of transcription and translation. This indicat...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(92)90529-t

    authors： Knutsen HK,Taskén KA,Eskild W,Hansson V

    更新日期：1992-03-16 00:00:00

  • Multiple myeloma cells adapted to long-exposure of hypoxia exhibit stem cell characters with TGF-β/Smad pathway activation.

    abstract：:The emergence of new molecular targeting agents has improved the prognosis of patients with multiple myeloma (MM). However, MM remains incurable because MM stem cells are likely resistant to these agents. Thus, it is important to further investigate the biology of MM stem cells, which reside in the hypoxic bone marrow...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2018.01.034

    authors： Nakagawa Y,Ashihara E,Yao H,Yokota A,Toda Y,Miura Y,Nakata S,Hirai H,Maekawa T

    更新日期：2018-02-05 00:00:00

  • Hereditary tyrosinemia type 1 metabolites impair DNA excision repair pathways.

    abstract：:Hereditary tyrosinemia type 1 is an autosomal recessive metabolic disorder, which is caused by a defective fumarylacetoacetate hydrolase enzyme, and consequently metabolites such as succinylacetone and p-hydroxyphenylpyruvate accumulate. We used a modified comet assay to determine the effect of these metabolites on ba...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2010.09.002

    authors： van Dyk E,Steenkamp A,Koekemoer G,Pretorius PJ

    更新日期：2010-10-08 00:00:00

  • Effects of the detergent sucrose monolaurate on binding of amphotericin B to sterols and its toxicity for cells.

    abstract：:Amphotericin B (AmB) is a potent antifungal agent used to treat patients with systemic mycoses. The cytotoxicity of AmB is related to its binding to membrane sterols and its clinical usefulness is based on its greater affinity to ergosterol, the fungal sterol, compared to the mammalian cell sterol, cholesterol (1-3). ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(88)90232-x

    authors： Gruda I,Gauthier E,Elberg S,Brajtburg J,Medoff G

    更新日期：1988-08-15 00:00:00

  • SUMOylation regulates nuclear localization and stability of TRAIP/RNF206.

    abstract：:TRAIP/RNF206 plays diverse roles in cell cycle progression, DNA damage response, and DNA repair pathways. Physiological importance of TRAIP is highlighted by the identification of pathogenic mutations of TRAIP gene in patients diagnosed with primordial dwarfism. Although the diverse functions of TRAIP in the nucleus h...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2016.01.141

    authors： Park IS,Han Yg,Chung HJ,Jung YW,Kim Y,Kim H

    更新日期：2016-02-19 00:00:00

  • The role of lipopolysaccharide moieties in macrophage response to Escherichia coli.

    abstract：:Lipopolysaccharide (LPS) is the main component of Gram-negative bacteria that - upon infection - activates the host immune system and is crucial in fighting pathogens as well as in the induction of sepsis. In the present study we addressed the question whether the key structural components of LPS equally take part in ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2009.08.082

    authors： Eder K,Vizler C,Kusz E,Karcagi I,Glavinas H,Balogh GE,Vigh L,Duda E,Gyorfy Z

    更新日期：2009-11-06 00:00:00

  • Two domains of the epidermal growth factor receptor are involved in cytoskeletal interactions.

    abstract：:Epidermal growth factor receptor can interact directly with F-actin through an actin-binding domain. In the present study, a mutant EGFR, lacking a previously identified actin-binding domain (ABD 1), was still able to bind elements of the cytoskeleton. A second EGFR actin-binding domain (ABD 2) was identified in the r...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.03.138

    authors： Song W,Wu J,Ge G,Lin Q

    更新日期：2008-06-13 00:00:00

  • Rundown of GH3 cell K+ conductance response to TRH following patch recording can be obviated with GH3 cell extract.

    abstract：:GH3/B6 pituitary cells release prolactin (PRL) in response to thyrotropin releasing hormone (TRH). Electrophysiological assays of individual GH3 cells with sharp high-resistance microelectrodes have revealed complex effects of TRH on membrane excitability consisting of a transient hyperpolarization (1), which is thoug...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(86)91222-2

    authors： Dufy B,MacDermott A,Barker JL

    更新日期：1986-05-29 00:00:00

  • Regulation of proteins involved in insulin signaling pathways in differentiating human adipocytes.

    abstract：:In the present study we have examined the proteins involved in the insulin signaling cascade during and after differentiation of human adipocyte precursor cells and their correlation with glucose uptake. The differentiation of human adipocytes was characterized by a two- to threefold stimulation of glucose transport i...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2000.3429

    authors： Pederson T,Rondinone CM

    更新日期：2000-09-16 00:00:00

  • Rapamycin alleviates cisplatin-induced ototoxicity in vivo.

    abstract：BACKGROUND:Cisplatin-induced ototoxicity affects a high percentage of new cancer patients worldwide. The detailed mechanism of cisplatin-induced ototoxicity is not completely understood. We investigated whether rapamycin could protect rats from cisplatin-induced ototoxicity. METHODS:Forty-eight male Wistar rats were r...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2014.04.123

    authors： Fang B,Xiao H

    更新日期：2014-06-13 00:00:00

  • Hypoxia is a strong inducer of vascular endothelial growth factor mRNA expression in the heart.

    abstract：:Vascular endothelial growth factor (VEGF) is a potent and specific mitogen for vascular endothelial cells. A 3.9 kb VEGF transcript is expressed by all cardiac tissues from rat, mouse and guinea pig examined. VEGF expression was not developmentally regulated. The major form of VEGF mRNAs expressed by cardiac tissues c...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1993.2144

    authors： Ladoux A,Frelin C

    更新日期：1993-09-15 00:00:00

  • Functional characterization of malaria parasites deficient in the K+ channel Kch2.

    abstract：:K+ channels are integral membrane proteins, which contribute to maintain vital parameters such as the cellular membrane potential and cell volume. Malaria parasites encode two K+ channel homologues, Kch1 and Kch2, which are well-conserved among members of the Plasmodium genus. In the rodent malaria parasite P. berghei...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.08.128

    authors： Ellekvist P,Mlambo G,Kumar N,Klaerke DA

    更新日期：2017-11-04 00:00:00

  • Trafficking of astrocytic vesicles in hippocampal slices.

    abstract：:The increasingly appreciated role of astrocytes in neurophysiology dictates a thorough understanding of the mechanisms underlying the communication between astrocytes and neurons. In particular, the uptake and release of signaling substances into/from astrocytes is considered as crucial. The release of different gliot...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2009.10.119

    authors： Potokar M,Kreft M,Lee SY,Takano H,Haydon PG,Zorec R

    更新日期：2009-12-25 00:00:00

  • BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis.

    abstract：:The execution phase of apoptosis is characterized by marked changes in cell morphology that include contraction and membrane blebbing. Little is known about the mechanisms underlying this process. We report here the identification of a novel member of BNIPL family, designated Bcl-2/adenovirus E1B 19kDa interacting pro...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(03)01387-1

    authors： Qin W,Hu J,Guo M,Xu J,Li J,Yao G,Zhou X,Jiang H,Zhang P,Shen L,Wan D,Gu J

    更新日期：2003-08-22 00:00:00

  • Cyclic AMP decreases LDL catabolism and cholesterol synthesis in the human hepatoma cell line HepG2.

    abstract：:A 24h pretreatment of the human hepatoma cell line HepG2 with dibutyryl cyclic AMP in the presence of theophylline induced a dose dependent decrease in low density lipoprotein binding, uptake and degradation. This effect is most likely due to a reduction of the LDL receptor number. Sterol synthesis from sodium acetate...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(88)80858-1

    authors： Maziere C,Maziere JC,Salmon S,Auclair M,Mora L,Moreau M,Polonovski J

    更新日期：1988-10-14 00:00:00

  • Nanomedicine for the molecular diagnosis of cardiovascular pathologies.

    abstract：:Predicting acute clinical events caused by atherosclerotic plaque rupture remains a clinical challenge. Anatomic mapping of the vascular tree provided by standard imaging technologies is not always sufficient for a robust diagnosis. Yet biological mechanisms leading to unstable plaques have been identified and corresp...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章,评审

    doi：10.1016/j.bbrc.2015.06.138

    authors： Juenet M,Varna M,Aid-Launais R,Chauvierre C,Letourneur D

    更新日期：2015-12-18 00:00:00

  • Effect of superoxide and lipid peroxide on cytosolic free calcium concentration in cultured pig aortic endothelial cells.

    abstract：:The effect of reactive oxygen on cytosolic free calcium concentration [( Ca++]i) in pig aortic endothelial cells (ECs) was studied. Linoleate hydroperoxide (LHO) and superoxide radicals generated from xanthine with xanthine oxidase (X-XO) were used as sources of reactive oxygen. [Ca++]i in ECs was measured with quin 2...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(88)80714-9

    authors： Hirosumi J,Ouchi Y,Watanabe M,Kusunoki J,Nakamura T,Orimo H

    更新日期：1988-04-15 00:00:00

  • Cloning, expression, and mapping of hWW45, a novel human WW domain-containing gene.

    abstract：:WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. The cloning and characterization of a novel human WW domain-containing gene, hWW45, which encodes a protein of app...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2000.3582

    authors： Valverde P

    更新日期：2000-10-05 00:00:00

  • Chemically induced Parkinson's disease. II: Intermediates in the oxidation and reduction reactions of the 1-methyl-4-phenyl-2,3-dihydropyridinium ion and its deprotonated form.

    abstract：:The one-electron reduction product of 1-methyl-4-phenyl-2,3-dihydropyridinium ion has been generated by pulse radiolysis and its absorption spectrum recorded. This radical was found to decay by second-order kinetics (2k = 9.5 x 10(8) M-1 s-1) to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 1-methyl-4-phenyl-2,3-di...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(89)80177-9

    authors： Chacón JN,Chedekel MR,Land EJ,Truscott TG

    更新日期：1989-01-16 00:00:00

  • Unusual adult-onset Leigh syndrome presentation due to the mitochondrial m.9176T>C mutation.

    abstract：:Leigh syndrome (LS) is an incurable, nearly always fatal, neurodegenerative, pediatric disorder that results from respiratory chain failure. The most common mitochondrial DNA (mtDNA) mutations that result in LS are m.8993T→C/G and m.9176T→C/G, which were previously found in several patients with early-onset Leigh synd...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2011.07.076

    authors： Ronchi D,Bordoni A,Cosi A,Rizzuti M,Fassone E,Di Fonzo A,Servida M,Sciacco M,Collotta M,Ronzoni M,Lucchini V,Mattioli M,Moggio M,Bresolin N,Corti S,Comi GP

    更新日期：2011-08-26 00:00:00

  • Identification of two novel insulin receptor mutations, Asp59Gly and Leu62Pro, in type A syndrome of extreme insulin resistance.

    abstract：:To elucidate genetic determinants of insulin resistance, we investigated insulin receptor (IR) and insulin receptor substrate-1 (IRS-1) genes, in vitro IR function and in vivo insulin sensitivity in a family with Type A syndrome. Two missense IR mutations (Asp59Gly and Leu62Pro) found in the proband, resulted in reduc...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1997.6695

    authors： Rouard M,Macari F,Bouix O,Lautier C,Brun JF,Lefebvre P,Renard E,Bringer J,Jaffiol C,Grigorescu F

    更新日期：1997-05-29 00:00:00

  • Rapid degradation of steroid sulfatase in multiple sulfatase deficiency.

    abstract：:Pulse labeling followed by SDS-PAGE electrophoresis of immunoprecipitated [35S]methionine-labeled steroid sulfatase (STS) gave a single band of molecular weight 65,000 daltons. After a chase period of 18 hours the material appeared as molecular weight approximately 64,000. No labeled STS could be detected in fibroblas...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(86)90007-0

    authors： Horwitz AL,Warshawsky L,King J,Burns G

    更新日期：1986-03-13 00:00:00

  • H(2)O(2)-induced AP-1 activation and its effect on p21(WAF1/CIP1)-mediated G2/M arrest in a p53-deficient human lung cancer cell.

    abstract：:Cellular response to oxidative stress is a complex process that is often connected to cell cycle regulation. The present study examines the effect of H(2)O(2) on cell cycle regulation and involvement of reactive oxygen species (ROS) in these H(2)O(2)-induced responses in a p53-deficient human lung carcinoma cell line,...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/S0006-291X(02)00360-1

    authors： Chung YW,Jeong DW,Won JY,Choi EJ,Choi YH,Kim IY

    更新日期：2002-05-17 00:00:00

  • Differential regulation of rat AT1a and AT1b receptor mRNA.

    abstract：:Rat type 1 angiotensin II receptor has two subtypes, namely type 1a and type 1b. The regulation of the expressions of these two subtype receptor mRNAs was studied by using a competitive polymerase chain reaction method. The expression of the type 1a mRNA in the liver was negatively and that of the type 1b mRNA in the ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(92)92384-a

    authors： Iwai N,Inagami T,Ohmichi N,Nakamura Y,Saeki Y,Kinoshita M

    更新日期：1992-10-15 00:00:00

  • A fraction of neurofibromin interacts with PML bodies in the nucleus of the CCF astrocytoma cell line.

    abstract：:Neurofibromatosis type 1 is a common genetic disease that causes nervous system tumors, and cognitive deficits. It is due to mutations within the NF1 gene, which encodes the Nf1 protein. Nf1 has been shown to be involved in the regulation of Ras, cAMP and actin cytoskeleton dynamics. In this study, using immunofluores...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.01.079

    authors： Godin F,Villette S,Vallée B,Doudeau M,Morisset-Lopez S,Ardourel M,Hevor T,Pichon C,Bénédetti H

    更新日期：2012-02-24 00:00:00

  • Demonstration of antigenic similarities and variations in excretory/secretory antigens of Toxoplasma gondii.

    abstract：:C57BL/6 mice were orally infected with different doses of cysts of ME49 strain of Toxoplasma gondii to produce groups of acutely and chronically infected mice. Sera were obtained at different periods post-infection. SDS-PAGE was ran with excretory/secretory antigens of ME49 and RH strains of T. gondii, followed by Wes...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(05)81491-3

    authors： Rahmah N,Anuar AK

    更新日期：1992-08-31 00:00:00

  • A potent and specific agonist, Suc-[Glu9,Ala11,15]-endothelin-1(8-21), IRL 1620, for the ETB receptor.

    abstract：:A series of C-terminal linear peptides of endothelin (ET)-1 and their N alpha-succinyl (Suc) analogs were synthesized and their binding affinities for the two subtypes of ET receptor, ETA and ETB, in porcine lung membranes were examined. Among the synthetic analogs, Suc-[Glu9,Ala11,15]-ET-1(8-21), IRL 1620, was the mo...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(92)90683-c

    authors： Takai M,Umemura I,Yamasaki K,Watakabe T,Fujitani Y,Oda K,Urade Y,Inui T,Yamamura T,Okada T

    更新日期：1992-04-30 00:00:00

  • Retinoic acid-induced differentiation-specific, C-kinase-dependent phosphorylation of cytosolic 44 and 32 kDa proteins in HL-60 cells.

    abstract：:The effect of various differentiation-inducers on the activity of Ca2+, phospholipid-dependent protein kinase (C-kinase) activity and endogenous protein phosphorylation by the kinase were examined in the extracts of HL-60 cells. Although all of the inducers, retinoic acid, dibutyryl cAMP, nicotinamide, dimethylsulfoxi...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(90)91163-m

    authors： Tanaka Y,Tsuyuki M,Itaya-Hironaka A,Inada Y,Yoshihara K,Kamiya T

    更新日期：1990-05-16 00:00:00

  • Lanthionine introduction into nukacin ISK-1 prepeptide by co-expression with modification enzyme NukM in Escherichia coli.

    abstract：:We demonstrated lanthionine introduction into hexa-histidine-tagged (His-tagged) nukacin ISK-1 prepeptide NukA by modification enzyme NukM in Escherichia coli. Co-expression of nukA and nukM, purification of the resulting His-tagged prepeptide by affinity chromatography, and subsequent mass spectrometry analysis showe...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.08.125

    authors： Nagao J,Harada Y,Shioya K,Aso Y,Zendo T,Nakayama J,Sonomoto K

    更新日期：2005-10-21 00:00:00

  • Proinflammatory cytokines regulate cyclooxygenase-2 mRNA expression in human macrophages.

    abstract：:Prostaglandins play a major role in the inflammatory and immune response. Macrophages constitutively produce prostaglandins by the enzyme cyclooxygenase-1 (cox) whereas inflammatory mediators and cytokines stimulate the inducible enzyme cox-2 for high output prostaglandin production. In this study, we investigated the...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1995.1378

    authors： Arias-Negrete S,Keller K,Chadee K

    更新日期：1995-03-17 00:00:00