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Hypoxia is a strong inducer of vascular endothelial growth factor mRNA expression in the heart.

Abstract：

:Vascular endothelial growth factor (VEGF) is a potent and specific mitogen for vascular endothelial cells. A 3.9 kb VEGF transcript is expressed by all cardiac tissues from rat, mouse and guinea pig examined. VEGF expression was not developmentally regulated. The major form of VEGF mRNAs expressed by cardiac tissues coded for VEGF188. Myocyte enriched and fibroblast enriched cultures of new born rat heart cells also expressed VEGF transcripts but the major mRNA found coded for VEGF164. The expression of VEGF mRNA in myocyte enriched cultures of new born rat ventricles was increased 2 fold by serum, 5 fold by phorbol myristate acetate and 7 fold by hypoxic conditions. We conclude that hypoxic conditions may promote cardiac capillary cell growth by inducing VEGF expression.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Ladoux A,Frelin C

doi

10.1006/bbrc.1993.2144

subject

Has Abstract

pub_date

1993-09-15 00:00:00

pages

1005-10

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(83)72144-3

journal_volume

195

pub_type

杂志文章

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