Cloning, expression, and mapping of hWW45, a novel human WW domain-containing gene.

abstract：:Caveolae are cholesterol enriched invaginations of the plasma membrane involved in a variety of processes, including glucose and fatty acids absorption, cell transduction and mechanoprotection. The biogenesis and function of caveolae depend on the activity of Caveolin (Cav-1, -2 and -3) and Cavin (Cavin-1, -2, -3 and ...

journal_title：Biochemical and biophysical research communications

authors： Codenotti S,Vezzoli M,Poliani PL,Cominelli M,Monti E,Fanzani A

更新日期：2017-11-04 00:00:00

abstract：:Prostaglandins (PGs) released by cultured rat Kupffer cells in response to stimulation with lipopolysaccharide (LPS) or ethanol were extracted from culture media, separated by HPLC and measured by radioimmunoassay. LPS (0.5-5 micrograms/ml) enhanced, after a 3-4 hrs lag period, the production of PGE2 (7-10 fold by 24 ...

journal_title：Biochemical and biophysical research communications

authors： Victorov AV,Hoek JB

更新日期：1995-10-13 00:00:00

abstract：:Mutations in the GDD1 gene cause gnathodiaphyseal dysplasia, a rare human skeletal syndrome with autosomal dominant inheritance. The biochemical function(s) of GDD1 protein and the molecular pathophysiology of GDD1 mutations leading to GDD have not yet been elucidated. In this study, we characterized the complete cDNA...

journal_title：Biochemical and biophysical research communications

authors： Tsutsumi S,Inoue H,Sakamoto Y,Mizuta K,Kamata N,Itakura M

更新日期：2005-06-17 00:00:00

abstract：:Neurons extend neurites with an increased synthesis of phosphatidylcholine (PC) that is not only a membrane component but also a functional regulator with specific fatty acid composition. To analyze the local synthesis of the PC molecular species within neurons, we combined a compartmentalized culture system with matr...

journal_title：Biochemical and biophysical research communications

authors： Sugiyama E,Yao I,Setou M

更新日期：2018-01-01 00:00:00

abstract：:Abnormal proliferation of vascular smooth muscle cells is a key event in the formation of atherosclerotic plaques in humans. It has been suggested that modulation of platelet derived growth factor chain A (PDGF-A) gene expression may contribute to atherosclerosis. Using an 'in situ hybridization' technique the present...

journal_title：Biochemical and biophysical research communications

authors： Zwijsen RM,Japenga SC,Heijen AM,van den Bos RC,Koeman JH

更新日期：1992-08-14 00:00:00

abstract：:Increasing antimicrobial drug resistance is a global threat especially with respect to Gram-negative bacteria. The low permeability of the bacterial outer cell wall has been identified as an important bottleneck that prevents a sufficient antibacterial effect to be achieved at low doses of the antibiotics. In particul...

journal_title：Biochemical and biophysical research communications

authors： Citak F,Ghai I,Rosenkötter F,Benier L,Winterhalter M,Wagner R

更新日期：2018-01-01 00:00:00

abstract：:ATP is the universal energy currency for all cells but has cellular concentrations of 2-12 mM, much higher than required for its classic functions. RNA-recognition motif (RRM) constitutes one of the most abundant domains in eukaryotes and most heterogeneous nuclear ribonucleoproteins (hnRNP) contain RRM domains which ...

journal_title：Biochemical and biophysical research communications

authors： Dang M,Kang J,Lim L,Li Y,Wang L,Song J

更新日期：2020-01-29 00:00:00

abstract：:In Dictyostelium discoideum, a novel type of RNA (dutA RNA), which is untranslatable, cytosolic and 1.3 kb in size, appears specifically after the aggregation stage [Yoshida, H. et al. (1994) Nucleic Acids Res. 22, 41-46]. We here show that the dutA gene is transcribed by RNA polymerase II, based on its alpha-amanitin...

journal_title：Biochemical and biophysical research communications

authors： Kumimoto H,Yoshida H,Okamoto K

更新日期：1995-11-02 00:00:00

abstract：:Intracellular symbiotic relationships are prevalent between cnidarians, such as corals and sea anemones, and the photosynthetic dinoflagellate symbionts. However, there is little understanding about how the genes express when the symbiotic relationship is set up. To characterize genes involved in this association, the...

journal_title：Biochemical and biophysical research communications

authors： Kuo J,Chen MC,Lin CH,Fang LS

更新日期：2004-05-21 00:00:00

abstract：:In the early postnatal period, cerebellar granule cells exhibit an activity-dependent downregulation of a set of immaturation genes involved in cell growth and migration and are shifted to establishment of a mature network formation. Through the use of a granule cell culture and both pharmacological and RNA interferen...

journal_title：Biochemical and biophysical research communications

authors： Okazawa M,Abe H,Nakanishi S

更新日期：2016-05-13 00:00:00

abstract：:Measurement and validation of microarray gene signatures in routine clinical samples is problematic and a rate limiting step in translational research. In order to facilitate measurement of microarray identified gene signatures in routine clinical tissue a novel method combining quantum dot based oligonucleotide in si...

journal_title：Biochemical and biophysical research communications

authors： Tholouli E,MacDermott S,Hoyland J,Yin JL,Byers R

更新日期：2012-08-24 00:00:00

abstract：:Osterix (Osx) has been shown to be an osteoblast-specific transcription factor for bone formation. Recently, it has been reported that Osx is significantly expressed in the mouse olfactory bulb, proving that Osx may play a role in olfactory bulb development, as well as bone development. Here, we studied morphological ...

journal_title：Biochemical and biophysical research communications

authors： Park JS,Park GI,Kim JE

更新日期：2016-09-09 00:00:00

abstract：:There are data suggesting that HMG1 protein may be involved in DNA replication. Recently we have found that only the acetylated form of the protein generates tetramers, stimulates the activity of DNA polymerase alpha (EC 2.7.7.7) (with activated DNA as a template) and forms a specific complex with it. This paper compa...

journal_title：Biochemical and biophysical research communications

authors： Dimov SI,Alexandrova EA,Beltchev BG

更新日期：1990-01-30 00:00:00

abstract：:Protein O-GlcNAcylation is proceeded by O-linked GlcNAc transferase (OGT) in nucleocytoplasm and is involved in many biological processes although its physiological role is not clearly defined. To identify the functional significance of O-GlcNAcylation, we investigated heat stress effects on protein O-GlcNAcylation. H...

journal_title：Biochemical and biophysical research communications

authors： Sohn KC,Lee KY,Park JE,Do SI

更新日期：2004-09-24 00:00:00

abstract：:PU.1 is a transcription factor found in macrophages, B cells, neutrophils, and hemopoietic stem cells. In macrophages PU.1 regulates a number of genes, including c-fms, CD11b, CD18, and FcgammaR1b. Previously, in primary macrophages PU.1 binding to the sequence GAGGAA was found to be induced by treatment with bacteria...

journal_title：Biochemical and biophysical research communications

authors： Xue Y,Alford P,Shackelford RE

更新日期：1999-01-08 00:00:00

abstract：:Tocopherols (vitamin E) located in the hydrophobic domains of biological membranes act as chain breaking antioxidants preventing the propagation of free radical reactions of lipid peroxidation. The naturally occurring form, d-alpha tocopherol is an exquisite molecule in that it is intercalated in the membrane in such ...

journal_title：Biochemical and biophysical research communications

authors： Stoyanovsky DA,Kagan VE,Packer L

更新日期：1989-04-28 00:00:00

abstract：:Allelic forms of hGSTP1-1 which differ from each other by their catalytic properties and, structurally, by the amino acid(s) in position(s) 104 or (and) 113 are known to exist in human populations. The four possible isoforms of hGSTP1-1 with isoleucine or valine in position 104 and with alanine or valine in position 1...

journal_title：Biochemical and biophysical research communications

authors： Hu X,Xia H,Srivastava SK,Herzog C,Awasthi YC,Ji X,Zimniak P,Singh SV

更新日期：1997-09-18 00:00:00

abstract：:Baeyer-Villiger monooxygenase (BVMO) catalyzes insertion of an oxygen atom into aliphatic or cyclic ketones with high regioselectivity. The BVMOs from Parvibaculum lavamentivorans (BVMOParvi) and Oceanicola batsensis (BVMOOcean) are interesting because of their homologies, with >40% sequence identity, and reaction wit...

journal_title：Biochemical and biophysical research communications

authors： Nguyen TD,Choi GE,Gu DH,Seo PW,Kim JW,Park JB,Kim JS

更新日期：2019-05-07 00:00:00

abstract：:Neuronal nitric oxide synthase (nNOS) is a calmodulin (CaM)-dependent enzyme, which generates the ubiquitous biological mediator nitric oxide. In this study, wild-type or mutant form of rat nNOS was overexpressed in a baculovirus/Sf9 insect cell system and examined for autophosphorylation. Incubation of purified wild-...

journal_title：Biochemical and biophysical research communications

authors： Watanabe Y,Terashima K,Hidaka H

更新日期：1996-02-15 00:00:00

abstract：:The myelin basic proteins (MBPs) are a family of polypeptides that are predominantly expressed in the nervous system where they play a major role in myelination. We have generated four lines of transgenic mice carrying a transgene in which 1.34 kb of the 5'-flanking sequence of the mouse MBP gene was fused upstream of...

journal_title：Biochemical and biophysical research communications

authors： Asipu A,Mellor AL,Blair GE

更新日期：2001-11-09 00:00:00

abstract：:HCV and HBV are the major causes of chronic liver diseases worldwide. Patients with both viruse's co-infection tend to develop severer liver diseases and are at high risk of liver-related death. NS5A protein of HCV plays key roles in HCV replication and inhibition of host immune responses. In this study, we described ...

journal_title：Biochemical and biophysical research communications

authors： Pan Y,Wei W,Kang L,Wang Z,Fang J,Zhu Y,Wu J

更新日期：2007-07-20 00:00:00

abstract：:Myostatin belongs to the transforming growth factor (TGF)-beta superfamily and is a potent negative regulator of skeletal muscle development and growth. We utilized microinjection of an antisense RNA-expressing vector to establish a hereditarily stable myostatin gene knockdown zebrafish strain with a double-muscle phe...

journal_title：Biochemical and biophysical research communications

authors： Lee CY,Hu SY,Gong HY,Chen MH,Lu JK,Wu JL

更新日期：2009-10-02 00:00:00

abstract：:Polyclonal, anti-idiotypic, rabbit antibodies have been raised against four murine monoclonal anti-morphine Fab fragments. The antibody preparations, after affinity purification, have been shown to contain an anti-paratypic fraction which reversibly inhibits morphine binding to the anti-morphine antibodies and to cell...

journal_title：Biochemical and biophysical research communications

authors： Glasel JA,Pelosi LA

更新日期：1986-05-14 00:00:00

abstract：:Corticosterone methyloxidase I (CMO I) deficiency is an autosomal recessive disorder of aldosterone biosynthesis. To determine further the molecular genetic basis of CMO I deficiency, a patient of Turkish origin that suffered from CMO I deficiency was studied. Nucleotide sequencing of the PCR-amplified exons from the ...

journal_title：Biochemical and biophysical research communications

authors： Nomoto S,Massa G,Mitani F,Ishimura Y,Miyahara K,Toda K,Nagano I,Yamashiro T,Ogoshi S,Fukata J,Onishi S,Hashimoto K,Doi Y,Imura H,Shizuta Y

更新日期：1997-05-19 00:00:00

abstract：:The Transforming Growth Factor-beta (TGF beta) family of polypeptides elicits diverse biological actions on a wide range of cell types. There are known to be several isoforms of TGF beta coded for by different genes, with possibly differential expression and potencies. We have demonstrated that there is constitutive e...

journal_title：Biochemical and biophysical research communications

authors： Frazer A,Seid JM,Hart KA,Bentley H,Bunning RA,Russell RG

更新日期：1991-10-31 00:00:00

abstract：:A great challenge for gene therapy is to develop a high efficient gene delivery system with low toxicity. Nonviral vectors are still attractive although the current agents displayed some disadvantages (i.e., low transfection efficiency, high toxicity). To overcome the high toxicity of poly(ethylene imine) (PEI) and lo...

journal_title：Biochemical and biophysical research communications

authors： Liang B,He ML,Xiao ZP,Li Y,Chan CY,Kung HF,Shuai XT,Peng Y

更新日期：2008-03-21 00:00:00

abstract：:It was previously shown that 5-hexyne-1,4-diamine is a potent enzyme-activated irreversible inhibitor of mammalian ornithine decarboxylase. However this compound has secondary pharmacological effects owing to its in vivo oxidation to 4-aminohex-5-ynoic acid, an irreversible inhibitor of 4-aminobutyrate aminotransferas...

journal_title：Biochemical and biophysical research communications

authors： Danzin C,Casara P,Claverie N,Metcalf BW,Jung MJ

更新日期：1983-10-14 00:00:00

abstract：:Growth hormone (GH) regulates many of the factors responsible for controlling the development of bone marrow progenitor cells (BMPCs). The aim of this study was to elucidate the role of GH in osteogenic differentiation of BMPCs using GH receptor null mice (GHRKO). BMPCs from GHRKO and their wild-type (WT) littermates ...

journal_title：Biochemical and biophysical research communications

authors： Cool SM,Grünert M,Jackson R,Li H,Nurcombe V,Waters MJ

更新日期：2005-12-16 00:00:00

abstract：:Separation of proteins by two-dimensional electrophoresis and following mass spectrometry (MS) is now a conventional technique for proteomic analysis. For proteomic analysis of a certain tissue with a limited information of primary structures of proteins, we have developed an analytical system for peptide mass fingerp...

journal_title：Biochemical and biophysical research communications

authors： Hozumi A,Satouh Y,Ishibe D,Kaizu M,Konno A,Ushimaru Y,Toda T,Inaba K

更新日期：2004-07-09 00:00:00

abstract：:Type III polyketide synthases (PKSs) play an important role in biosynthesis of various plant secondary metabolites and plant adaptation to environmental stresses. Aquilaria sinensis (A. sinensis) is the main plant species for production of agarwood, little is known about its PKS family. In this study, AsCHS1 and two n...

journal_title：Biochemical and biophysical research communications

authors： Wang X,Zhang Z,Dong X,Feng Y,Liu X,Gao B,Wang J,Zhang L,Wang J,Shi S,Tu P

更新日期：2017-05-13 00:00:00