Synthesis and characterization of folate-PEG-grafted-hyperbranched-PEI for tumor-targeted gene delivery.

abstract：:Wound healing in ligaments is a complex process which leads to functionally impaired scar tissue, even after extended time postinjury. To investigate the potential role of proteinases and inhibitors, as well as potential regulators of their expression, mRNA levels for collagenase, stromelysin, urokinase, PAI-1, and TI...

journal_title：Biochemical and biophysical research communications

authors： Reno C,Boykiw R,Martinez ML,Hart DA

更新日期：1998-11-27 00:00:00

abstract：:These studies sought to test the hypothesis that magnesium inhibits extracellular calcium entry, thereby inhibiting intracellular calcium release and cytosolic calcium oscillations in myometrial smooth muscle. In vitro contraction studies were performed using oxytocin and other uterotonic agonists with and without the...

journal_title：Biochemical and biophysical research communications

authors： Phillippe M

更新日期：1998-11-18 00:00:00

abstract：:(1S,5S,6R,7R)-7-Chloro-3-imino-5-methyl-2-azabicyclo[4.1.0]heptane hydrochloride (ONO-1714), a novel cyclic amidine analogue, inhibits human inducible nitric oxide (iNOS) with a K(i) of 1.88 nM and rodent iNOS with similar potency in vitro. ONO-1714 was found to be 10-fold selective for human iNOS over human endotheli...

journal_title：Biochemical and biophysical research communications

authors： Naka M,Nanbu T,Kobayashi K,Kamanaka Y,Komeno M,Yanase R,Fukutomi T,Fujimura S,Seo HG,Fujiwara N,Ohuchida S,Suzuki K,Kondo K,Taniguchi N

更新日期：2000-04-13 00:00:00

abstract：:Recent efforts have underlined the role of Serine/Threonine Protein Kinases (STPKs) in growth, pathogenesis and cell wall metabolism in mycobacteria. Herein, we demonstrated that the Mycobacterium tuberculosis EthR, a transcriptional repressor that regulates the activation process of the antitubercular drug ethionamid...

journal_title：Biochemical and biophysical research communications

authors： Leiba J,Carrère-Kremer S,Blondiaux N,Dimala MM,Wohlkönig A,Baulard A,Kremer L,Molle V

更新日期：2014-04-18 00:00:00

abstract：:Butyrate, a short-chain fatty acid produced in the colon, as well as its prodrug tributyrin, reduce proliferation and increase differentiation of colon cancer cells. p21(Waf1/Cip1) and p27(Kip1) are negative regulators of cell cycle and are thought to have a key function in the differentiation of various cell lines. W...

journal_title：Biochemical and biophysical research communications

authors： Gaschott T,Wächtershäuser A,Steinhilber D,Stein J

更新日期：2001-04-27 00:00:00

abstract：:To study the role of the cytoplasmic domain and particularly the tyrosine residues of the erythropoietin receptor (EpoR) in erythroid differentiation of human primary stem cells, we infected cord blood-derived CD34+ cells with retroviruses encoding chimeric receptors containing the extracellular domain of the prolacti...

journal_title：Biochemical and biophysical research communications

authors： Fichelson S,Chrétien S,Rokicka-Piotrowicz M,Bouhanik S,Gisselbrecht S,Mayeux P,Lacombe C

更新日期：1999-03-24 00:00:00

abstract：:We have previously reported that intraplatelet "cyclic AMP jumps" produced with newly synthesized photoactivatable cyclic AMP analogue, inhibited washed rat platelet aggregation and serotonin release as induced by thrombin. Using the same approach on human platelets, thrombin-induced platelet aggregation was dose-depe...

journal_title：Biochemical and biophysical research communications

authors： Blache D,Ciavatti M,Ponsin G,Nargeot J

更新日期：1987-07-15 00:00:00

abstract：:Monoclonal antibody BB1 was previously shown to recognize the CD80 protein as well as a putative B7.3 molecule, both ligands of the important T-cell receptors CD28 and CTLA-4. We report that BB1 coprecipitated from detergent lysates of human B- and pre-B-cell lines a protein kinase activity, as detected by solid phase...

journal_title：Biochemical and biophysical research communications

authors： Angelisová P,Cerný J,Horejsí V

更新日期：1996-11-12 00:00:00

abstract：:We have recently reported that mutant but not wild-type (wt) p53 protein was ADP-ribosylated in primary rat cells overexpressing the temperature-sensitive murine p53val135 gene. To examine whether the lack of susceptibility to modification is a specific feature of p53val135 adopting wt conformation or rather a general...

journal_title：Biochemical and biophysical research communications

authors： Wesierska-Gadek J,Schmid G,Cerni C

更新日期：1996-07-05 00:00:00

abstract：:Promyelocytic leukaemia (PML) is a tumor suppressor protein covalently conjugated with SUMO family proteins, leading to the formation of PML nuclear bodies (NBs). PML-NBs provide a platform for efficient posttranslational modification of targets and protein-protein interaction, contributing to the adjustment of gene e...

journal_title：Biochemical and biophysical research communications

authors： Fukuda T,Kigoshi-Tansho Y,Naganuma T,Kazaana A,Okajima T,Tsuruta F,Chiba T

更新日期：2017-01-22 00:00:00

abstract：:The retinoic acid related orphan receptor RORalpha activates transcription of genes that play an important role in cerebellar development, the protection against age-related degenerative processes, the regulation of inflammatory responses, and is one of the pivotal participants that control the circadian rhythmicity i...

journal_title：Biochemical and biophysical research communications

authors： Lechtken A,Hörnig M,Werz O,Corvey N,Zündorf I,Dingermann T,Brandes R,Steinhilber D

更新日期：2007-07-06 00:00:00

abstract：:Activation of the classical IκB kinases (IKKα and IKKβ) was previously shown to contribute to obesity-induced inflammation and insulin resistance. Using knockout mice, we investigated whether the related isoform IKKε plays a similar metabolic role. IKKε(-/-) mice had reduced body weight, leptin levels, as well as high...

journal_title：Biochemical and biophysical research communications

authors： Scheja L,Heese B,Seedorf K

更新日期：2011-04-08 00:00:00

abstract：:The effect of acetaminophen (APAP) dose on the cytochrome P450s responsible for its bioactivation was examined in control mice and mice treated with acetone to induce CYP2E1, or beta-napthaflavone to induce CYP1A2. In non-induced mice, 150 mg/kg APAP caused minimal hepatotoxicity and loss of CYP2E1- but not CYP1A2-dep...

journal_title：Biochemical and biophysical research communications

authors： Snawder JE,Roe AL,Benson RW,Roberts DW

更新日期：1994-08-30 00:00:00

abstract：:Cancer cells show characteristic telomere dynamics. Their chromosomes usually have short telomeres and a high telomerase activity. The "telomere crisis model" proposed here suggests that these unique telomeric features are responsible for the progression of cancer. ...

journal_title：Biochemical and biophysical research communications

authors： Ishikawa F

更新日期：1997-01-03 00:00:00

abstract：:CYP27A1 catalyses hydroxylations in the biosynthesis of bile acids and the bioactivation of vitamin D3. We investigated the expression of CYP27A1 in human monocytes, monocyte-derived macrophages, and dendritic cells on mRNA and protein levels as well as its enzymatic activity in comparison with the expression of CYP27...

journal_title：Biochemical and biophysical research communications

authors： Gottfried E,Rehli M,Hahn J,Holler E,Andreesen R,Kreutz M

更新日期：2006-10-13 00:00:00

abstract：:An antifungal protein that inhibits the growth of filamentous fungal pathogens was isolated from Chinese cabbage (Brassica campestris L. ssp. pekinensis) by affinity chromatography on Affi-gel blue gel and ion exchange chromatography on CM-Sepharose. The N-terminal amino acid sequence of the protein was highly homolog...

journal_title：Biochemical and biophysical research communications

authors： Lee JR,Park SC,Kim JY,Lee SS,Park Y,Cheong GW,Hahm KS,Lee SY

更新日期：2007-02-16 00:00:00

abstract：:We have examined the role of K+ channels in mediating vasorelaxation produced by bacterial lipopolysaccharide (LPS) in endothelial-denuded strips of rat aorta precontracted with phenylephrine (1 microM). Salmonella typhosa LPS (0.1 microgram/ml) caused significant relaxation of tension which peaked at approximately 4h...

journal_title：Biochemical and biophysical research communications

authors： Hall S,Turcato S,Clapp L

更新日期：1996-07-05 00:00:00

abstract：:MicroRNAs play critical roles in skeletal muscle development as well as in regulation of muscle cell proliferation and differentiation. Previous study in our laboratory showed that the expression level of miR-2400, a novel and unique miRNA from bovine, had significantly changed in skeletal muscle-derived satellite cel...

journal_title：Biochemical and biophysical research communications

authors： Zhang WW,Tong HL,Sun XF,Hu Q,Yang Y,Li SF,Yan YQ,Li GP

更新日期：2015-08-07 00:00:00

abstract：:A major protein AA amyloid protein was purified and characterised from a Papua New Guinnean individual. This AA protein differed from all previously characterised SAA variants by the combination of Ala52, Val57, Asn60, Phe68, Phe69 and Gly72. Since the prevalence of AA-amyloidosis is unusually high in Papua New Guinea...

journal_title：Biochemical and biophysical research communications

authors： Westermark P,Sletten K,Westermark GT,Raynes J,McAdam KP

更新日期：1996-06-14 00:00:00

abstract：AIMS:To investigate dynamic changes in the expression of HCN2, HCN4, as well as KCNE1, and KCNE2 mRNA and protein levels in ventricular cells from acute myocardial infarction (AMI) rat hearts. MAIN METHODS:An AMI model was induced by ligating the left anterior descending coronary artery (LAD) of Sprague-Dawley rats. T...

journal_title：Biochemical and biophysical research communications

authors： Xia S,Wang Y,Zhang Y,Deng SB,Du JL,Wang XC,She Q

更新日期：2010-05-07 00:00:00

abstract：:We examined the effect of low density lipoprotein (LDL) on histamine release from purified human lung mast cells. LDL inhibited anti-IgE- induced histamine release in a dose-dependent manner, with 100 micrograms/ml LDL-protein inhibiting histamine release by 53 +/- 8% (mean +/- SEM); half-maximal inhibition occurred a...

journal_title：Biochemical and biophysical research communications

authors： Schulman ES,Quinn TJ,Post TJ,O'Donnell P,Rodriguez A,Gonen B

更新日期：1987-10-29 00:00:00

abstract：:Manganese superoxide dismutase (GP-MnSOD), a component of the so-called 'green protein' (green protein complex) from the facultative anaerobic halodenitrifier Bacillus halodenitrificans, has been crystallized using the hanging-drop vapor diffusion method. Crystals have unit-cell parameters a=b=93.4 A, c=65.0 A, and be...

journal_title：Biochemical and biophysical research communications

authors： Liao J,Li M,Liu MY,Chang T,Le Gall J,Gui LL,Zhang JP,Liang DC,Chang WR

更新日期：2002-05-31 00:00:00

abstract：:Deregulation of the expression of human papillomavirus (HPV) oncogenes E6 and E7 plays a pivotal role in cervical carcinogenesis because the E6 and E7 proteins neutralize p53 and Rb tumor suppressor pathways, respectively. In approximately 90% of all cervical carcinomas, HPVs are found to be integrated into the host g...

journal_title：Biochemical and biophysical research communications

authors： Lee K,Lee AY,Kwon YK,Kwon H

更新日期：2011-08-26 00:00:00

abstract：:Formation of endothelium-derived relaxing factor (EDRF) strictly correlates with the intracellular free Ca2+ ([Ca2+]i) concentration. We now demonstrate that the histamine-induced rise in [Ca2+]i of human umbilical vein endothelial cells is mostly due to activation of a membrane current which allows Ca2+ entry. This m...

journal_title：Biochemical and biophysical research communications

authors： Graier WF,Groschner K,Schmidt K,Kukovetz WR

更新日期：1992-08-14 00:00:00

abstract：:Phospholipase C (PLC) has been known to be a key effector protein in signal transduction pathway for cell proliferation and differentiation. Here, we report the transcriptional regulation of PLC-gamma 1 during myogenic differentiation. Both PLC-gamma 1 mRNA and protein levels were increased during myogenesis. The acti...

journal_title：Biochemical and biophysical research communications

authors： Lee SJ,Lee YH,Kim YS,Ryu SH,Suh PG

更新日期：1995-01-05 00:00:00

abstract：:We describe a novel technology for detecting nucleic acids: Probe Alteration Link Self-Assembly Reactions (PALSAR). PALSAR comprises DNA self-assembly of pairs of short DNA probes formed by alternate hybridization of three complementary regions in a pair of honeycomb probes (HCPs). Self-assembly occurs at designated s...

journal_title：Biochemical and biophysical research communications

authors： Usui M,Fujikawa T,Osawa M,Hakii C,Ikumi N,Nozaki T,Kitamura N,Hatta Y,Fujiwara S,Takei M

更新日期：2015-11-27 00:00:00

abstract：:To investigate the role of activation of c-Jun NH2-terminal kinase 1 (JNK1) in mediating cisplatin-induced apoptosis and the possibility of induction of JNK activity in triggering relation to DNA damage and drug resistance. We investigated the difference of cisplatin-induced activation of JNK pathway and H2O2 alterati...

journal_title：Biochemical and biophysical research communications

authors： Li F,Meng L,Zhou J,Xing H,Wang S,Xu G,Zhu H,Wang B,Chen G,Lu YP,Ma D

更新日期：2005-10-07 00:00:00

abstract：:Sequence-specific hybridization of antisense and antigene agent to the target nucleic acid is an important therapeutic strategy to modulate gene expression. However, efficiency of such agents falls due to inherent intramolecular-secondary-structures present in the target that pose competition to intermolecular hybridi...

journal_title：Biochemical and biophysical research communications

authors： Kaur H,Wengel J,Maiti S

更新日期：2007-01-05 00:00:00

abstract：:Intestinal epithelial cells participate in an acute phase response (APR) by responding to cytokines and by expressing acute phase protein genes. We hypothesized that butyrate, a fermentation product of the bacterial intestinal flora with deacetylase activity, affects the APR in intestinal epithelial cells. Sodium buty...

journal_title：Biochemical and biophysical research communications

authors： Désilets A,Gheorghiu I,Yu SJ,Seidman EG,Asselin C

更新日期：2000-09-24 00:00:00

abstract：:Cell adhesion molecules act as tumor suppressors primarily by cell attachment activity, but additional mechanisms modifying signal transduction are suggested in some cases. Cell adhesion molecule 1 (CADM1), a membrane-spanning immunoglobulin superfamily, mediates intercellular adhesion by trans-homophilic interaction ...

journal_title：Biochemical and biophysical research communications

authors： Tsuboi Y,Oyama M,Kozuka-Hata H,Ito A,Matsubara D,Murakami Y

更新日期：2020-08-27 00:00:00