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DRG: a novel developmentally regulated GTP-binding protein.

Abstract：

:Using a subtraction cloning approach we had previously isolated a series of murine cDNA clones representing the genes predominantly expressed in the embryonic brain and down-regulated during development. We now report that one of these cDNA clones encodes a novel type of GTP-binding protein. The predicted protein of 40.5 kD, named DRG, contains five structural motifs characteristic of the GTP-binding proteins. Consistently, bacterially expressed and cellular DRG proteins are capable of binding GTP in vitro. Sequences closely related to the DRG protein are found in other species including Drosophila and Halobacterium. Based on these observations, we propose that DRG represents an evolutionarily conserved novel class of GTP-binding protein which may play an important role in cell physiology.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Sazuka T,Tomooka Y,Ikawa Y,Noda M,Kumar S

doi

10.1016/0006-291x(92)91567-a

subject

Has Abstract

pub_date

1992-11-30 00:00:00

pages

363-70

issue

1

eissn

0006-291X

issn

1090-2104

pii

0006-291X(92)91567-A

journal_volume

189

pub_type

杂志文章

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