Decrease in the T-box1 gene expression in embryonic brain and adult hippocampus of down syndrome mouse models.

abstract：:Intracellular Ca2+ plays an important role in a variety of second messenger cascades. The function of Ca2+ is mediated, in part, by Ca2+-binding proteins such as calmodulin, calretinin, calbindin, neurocalcin, recoverin, and visinin-like proteins (VILIPs). These proteins are highly expressed in rat olfactory receptor ...

journal_title：Biochemical and biophysical research communications

authors： Mammen A,Simpson PJ,Nighorn A,Imanishi Y,Palczewski K,Ronnett GV,Moon C

更新日期：2004-10-01 00:00:00

abstract：:Growth cone extension is guided by extracellular factors during the brain development but the underlying cellular mechanisms remain largely unclear. Here, we examined the potential function of class-3 semaphorins in cultured cerebellar granule cells. We found neuropilin-2 (NP2), the high-affinity receptor for semaphor...

journal_title：Biochemical and biophysical research communications

authors： Ding S,Luo JH,Yuan XB

更新日期：2007-05-18 00:00:00

abstract：:This article investigated the effects of pramipexole on myocardial ischemia reperfusion (I/R) injury and its underlying mechanisms. We utilized an in vivo mouse model of myocardial I/R injury and an in vitro H9c2 cell model of hypoxia/reoxygenation (H/R) injury. Pramipexole pretreatment in male C57BL/6 mice significan...

journal_title：Biochemical and biophysical research communications

authors： Mo Y,Tang L,Ma Y,Wu S

更新日期：2016-05-13 00:00:00

abstract：:Here we established a unique human glial cell line, GDC90, derived from a human glioma and demonstrated its utility as a glial scaffold for the polarization and differentiation of human induced pluripotent stem cell-derived neural progenitor cells (iPSC-NPCs). When co-cultured with GDC90 cells, iPSC-NPCs underwent rap...

journal_title：Biochemical and biophysical research communications

authors： Bamba Y,Shofuda T,Kanematsu D,Nonaka M,Yamasaki M,Okano H,Kanemura Y

更新日期：2014-05-16 00:00:00

abstract：:Human dendritic cells (DC) are key regulators of innate and adaptive immunity that can be divided in at least three major subpopulations: plasmacytoid DC (pDC), myeloid type 1 DC (mDC1) and myeloid type 2 DC (mDC2) exhibiting different functions. However, research, diagnostic and cell therapeutic studies on human DC s...

journal_title：Biochemical and biophysical research communications

authors： Schütz F,Hackstein H

更新日期：2014-01-10 00:00:00

abstract：:The primary amino acid sequence of the carboxyl-terminal portion of the alpha 3 chain of chicken type VI collagen (K-VI) presents a 58-residue motif with a high degree of homology with members of the Kunitz serine-proteinase inhibitors family. This module was cloned, expressed in E. coli, purified and compared to the ...

journal_title：Biochemical and biophysical research communications

authors： Bearz A,Tolazzi G,Leonardi A,Pucillo C,Tell G,Colombatti A,Formisano S

更新日期：1995-10-24 00:00:00

abstract：:The Rex-family repressors sense redox levels by alternative binding to NADH or NAD(+). RSP is the homologue of Rex in Thermoanaerobacter ethanolicus JW200(T) and regulates ethanol fermentation in this obligate anaerobe. The dimeric repressor binds to DNA by an open conformation. The crystal structure of RSP/α-NAD(+) c...

journal_title：Biochemical and biophysical research communications

authors： Zheng Y,Ko TP,Yang Y,Shao W,Guo RT

更新日期：2015-01-16 00:00:00

abstract：:A procedure is described for preparation of homogeneous inositol monophosphate phosphatase (EC 3.1.3.25) from beef brain in less than 2 days with an overall recovery of 15-25%. This enzyme, an essential part of the inositol phospholipid cycle in brain, is a proposed site of action of lithium ions in manic-depressive d...

journal_title：Biochemical and biophysical research communications

authors： Meek JL,Rice TJ,Anton E

更新日期：1988-10-14 00:00:00

abstract：:The present study was undertaken to evaluate the functional significance of the previously observed increase in the level of IGF-II receptors despite the loss of growth promoting activity of IGF-II in differentiated limb buds in organ culture. In the present study IGF-II and insulin at similar concentration (0.1-1 mic...

journal_title：Biochemical and biophysical research communications

authors： Bhaumick B,Bala RM

更新日期：1988-04-15 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer-related death worldwide. So far, almost all treatments are almost ineffective for pancreatic cancer. Thus, there is an urgent need to develop novel therapeutics for pancreatic cancer treatment. Immune checkpoints blockade therapies, includi...

journal_title：Biochemical and biophysical research communications

authors： Fan P,Ma J,Jin X

更新日期：2018-11-02 00:00:00

abstract：:It has been proposed that the inositol 1,4,5-trisphosphate receptor (InsP(3)R) type III acts as a trigger for InsP(3)-mediated calcium (Ca(2+)) signaling, because this InsP(3) isoform lacks feedback inhibition by cytosolic Ca(2+). We tested this hypothesis in RIN-m5F cells, which express predominantly the type III rec...

journal_title：Biochemical and biophysical research communications

authors： O'Neill AF,Hagar RE,Zipfel WR,Nathanson MH,Ehrlich BE

更新日期：2002-06-14 00:00:00

abstract：:In the investigation of the intracellular sites of insulin degradation, it might be important whether receptor-bound insulin could be a substrate for insulin-degrading enzyme (IDE). Insulin receptor and IDE were purified from rat liver using a wheat germ agglutinin column and monoclonal anti-IDE antibody affinity colu...

journal_title：Biochemical and biophysical research communications

authors： Yonezawa K,Yokono K,Shii K,Hari J,Yaso S,Amano K,Sakamoto T,Kawase Y,Akiyama H,Nagata M

更新日期：1988-01-29 00:00:00

abstract：:Intranuclear inclusions have been observed in the brains of patients affected with Huntington's disease (HD). Neuro 2A cells that transiently expressed HD exon 1 bearing 74 glutamine repeats linked to the green fluorescent protein (GFP) and the nuclear localization sequence (NLS) contained aggregates in nuclei. The ag...

journal_title：Biochemical and biophysical research communications

authors： Hazeki N,Tsukamoto T,Yazawa I,Koyama M,Hattori S,Someki I,Iwatsubo T,Nakamura K,Goto J,Kanazawa I

更新日期：2002-06-07 00:00:00

abstract：:Antithrombin III (ATIII) performs a critical anticoagulant function by precluding the activation of blood clotting proteinases, aided by its two cofactors, heparin and heparan sulfate. Though several studies have been carried out on physiological, biochemical and structural perspectives on ATIII, so far there are limi...

journal_title：Biochemical and biophysical research communications

authors： Kumar A,Bhandari A,Sarde SJ,Goswami C

更新日期：2013-11-01 00:00:00

abstract：:Angiogenesis plays a pivotal role in gastric ulcer repair. Several growth factors are involved in angiogenesis, and of these, vascular endothelial growth factor (VEGF) has received considerable attention, since it is the only factor that specifically acts on endothelial cells. However, the role of VEGF in gastric ulce...

journal_title：Biochemical and biophysical research communications

authors： Takahashi M,Kawabe T,Ogura K,Maeda S,Mikami Y,Kaneko N,Terano A,Omata M

更新日期：1997-05-19 00:00:00

abstract：:CD40-stimulated human B lymphocytes are highly permissive to a productive infection by the human immunodeficiency virus type 1. In these cells, nuclear factors involved in activation of the HIV-1 LTR, which contains the transcriptional control elements of the virus, are unknown. Transient expression assays with plasmi...

journal_title：Biochemical and biophysical research communications

authors： Lapointe R,Lemieux R,Darveau A

更新日期：1996-12-24 00:00:00

abstract：:The primary structure of human selenium-dependent phospholipid hydroperoxide glutathione peroxidase (GPX4) was determined by genomic cloning. The gene structure of GPX4 spans only 2.8 kb and consists of 7 exons. The coding sequence resides on all 7 exons, and the mitochondrial leader sequence is contained entirely wit...

journal_title：Biochemical and biophysical research communications

authors： Kelner MJ,Montoya MA

更新日期：1998-08-10 00:00:00

abstract：:We have characterized the promoter of the human gene coding for the apoferritin L subunit. Transient transfections of 5' and 3' deletion mutants indicate that the efficiency of the L promoter depends on both negative and positive cis-elements, located upstream and downstream of the transcription start point. DNaseI fo...

journal_title：Biochemical and biophysical research communications

authors： D'Agostino P,Faniello MC,Quaresima B,Bevilacqua MA,Tiano MT,Ammendola R,Cimino F,Costanzo F

更新日期：1995-10-04 00:00:00

abstract：:By constructing a new type of thermal detector, rapid production of heat was demonstrated during the rising phase of the action potential of the eel electric organs evoked by direct electric stimulation. Following the indirect (synapse-mediated) action potential of the organs, the existence of very large and variable ...

journal_title：Biochemical and biophysical research communications

authors： Tasaki I,Byrne PM

更新日期：1993-12-15 00:00:00

abstract：:The yeast Saccharomyces cerevisiae is able to sense the availability and quality of nitrogen sources and the intrinsic variation of amino acid disponibility for protein synthesis. When this yeast is provided with secondary nitrogen sources, transcription of genes encoding enzymes involved in their catabolism is elicit...

journal_title：Biochemical and biophysical research communications

authors： Hernández H,Aranda C,Riego L,González A

更新日期：2011-01-21 00:00:00

abstract：:Plucked (pk) is an autosomal recessive mouse mutation with a hair phenotype that arose spontaneously in the DBA/2J strain. Histological studies indicate that adult pk mutant mice lose truncal hair because of the scarring of follicles due to an apparent obstruction of the outward movement of the hair shaft within the f...

journal_title：Biochemical and biophysical research communications

authors： Luo J,Zhang L,Stenn K,Prouty S,Parimoo S

更新日期：2005-02-04 00:00:00

abstract：:Chlorophyllide a oxygenase (CAO) that converts chlorophyllide a to chlorophyllide b was overexpressed in tobacco to increase chlorophyll (Chl) b biosynthesis and alter the Chl a/b ratio. Transgenic plants along with their wild-type cultivars were grown in low and high light intensities. In low light there was 20% incr...

journal_title：Biochemical and biophysical research communications

authors： Pattanayak GK,Biswal AK,Reddy VS,Tripathy BC

更新日期：2005-01-14 00:00:00

abstract：:The Ca2+- and phospholipid-dependent protein kinase C from rat brain phosphorylates rabbit muscle phosphofructokinase at the same trypsin-labile site as cyclic AMP-dependent protein kinase. However, protein kinase C also effectively phosphorylates one or more separate sites. Incubation of phosphofructokinase in the pr...

journal_title：Biochemical and biophysical research communications

authors： Hofer HW,Schlatter S,Graefe M

更新日期：1985-06-28 00:00:00

abstract：:Rheumatoid arthritis (RA) is an autoimmune inflammatory disease exhibited most commonly in joints. We found that the expression of C1qtnf3, which encodes C1q/TNF-related protein 3 (CTRP3), was highly increased in two mouse RA models with different etiology. To elucidate the pathogenic roles of CTRP3 in the development...

journal_title：Biochemical and biophysical research communications

authors： Murayama MA,Kakuta S,Maruhashi T,Shimizu K,Seno A,Kubo S,Sato N,Saijo S,Hattori M,Iwakura Y

更新日期：2014-01-03 00:00:00

abstract：:Expression of the mouse cytokeratin EndoA gene is regulated by an enhancer that is located 1 kilobases (kb) 3' downstream from the gene. The EndoA enhancer consists of six direct repeats with homology to the PEA3 motif in the polyoma virus enhancer core. The PEA3 motif binds to the proto-oncogene Ets product. In this ...

journal_title：Biochemical and biophysical research communications

authors： Hamazato F,Fujimura Y,Tamai Y,Takemoto Y,Matsushiro A,Nozaki M

更新日期：1993-04-30 00:00:00

abstract：:Factors affecting Ins(1,3,4,5)P4-mediated nuclear Ca2+ uptake are investigated, which include Ins(1,3,4,5)P4 receptor ligand specificity and free external Ca2+ concentrations. Among various inositol phosphates examined, Ins(1,3,4,5)P4, Ins(3,4,5,6)P4, and Ins(1,3,4,5,6)P5 can also stimulate 45Ca2+ influx into isolated...

journal_title：Biochemical and biophysical research communications

authors： Hsu AL,Lu PJ,Chen CS

更新日期：1998-02-24 00:00:00

abstract：:With the global pandemic of hepatitis B and C infections, the incidence of Hepatocellular carcinoma (HCC) is rapidly increasing world wide. We identified glypican-3 (GPC3), a novel oncofetal gene over-expressed specifically in human HCC, as based on data of cDNA microarrays. As GPC3 is a GPI-anchored membrane protein ...

journal_title：Biochemical and biophysical research communications

authors： Nakatsura T,Yoshitake Y,Senju S,Monji M,Komori H,Motomura Y,Hosaka S,Beppu T,Ishiko T,Kamohara H,Ashihara H,Katagiri T,Furukawa Y,Fujiyama S,Ogawa M,Nakamura Y,Nishimura Y

更新日期：2003-06-20 00:00:00

abstract：:In order to study the relationship between insulin like growth factor-II (IGF-II) and interleukin-8 (IL-8) that are upregulated in psoriasis, we monitored IL-8 expression in IGF-II-treated human keratinocytes and explored the signaling pathways of IL-8 expression by IGF-II. IGF-II increased the IL-8 mRNA and protein l...

journal_title：Biochemical and biophysical research communications

authors： Kim HJ,Byun SJ,Kim TY

更新日期：2004-04-23 00:00:00

abstract：:Endothelin-1 (ET-1) is an endothelium-derived vasoconstrictor peptide with potent pressor activity. We studied the effect of ET-1 on release of arginine-vasopressin (AVP) from perifused rat hypothalamus. ET-1 (10(-10) to 10(-8) M) significantly stimulated AVP release. The ET-1-induced AVP release was completely blocke...

journal_title：Biochemical and biophysical research communications

authors： Shichiri M,Hirata Y,Kanno K,Ohta K,Emori T,Marumo F

更新日期：1989-09-29 00:00:00

abstract：:Concanavalin A (ConA), a Ca(2+)/Mn(2+)-dependent and mannose/glucose-binding legume lectin, has drawn a rising attention for its remarkable anti-proliferative and anti-tumor activities to a variety of cancer cells. ConA induces programmed cell death via mitochondria-mediated, P73-Foxo1a-Bim apoptosis and BNIP3-mediate...

journal_title：Biochemical and biophysical research communications

authors： Li WW,Yu JY,Xu HL,Bao JK

更新日期：2011-10-22 00:00:00