Possible involvement of group I mGluRs in neuroprotective effect of theanine.

abstract：:Vasodilator-stimulated phosphoprotein (VASP) is an actin regulatory protein that functions in adhesion and migration. In epithelial cells, VASP participates in cell-cell adhesion. At the molecular level, VASP drives actin bundling and polymerization. VASP activity is primarily regulated by phosphorylation. Three physi...

journal_title：Biochemical and biophysical research communications

authors： Thomson DM,Ascione MP,Grange J,Nelson C,Hansen MD

更新日期：2011-10-14 00:00:00

abstract：:Endothelin (ET)-1 and big ET-1 both caused contraction of isolated porcine coronary arteries, but the potency of big ET-1 was 1/100-1/200 that of ET-1. These responses were independent of the vascular endothelium. Phosphoramidon blocked the vasoconstriction caused by 30 nM big ET-1, but was ineffective on the action o...

journal_title：Biochemical and biophysical research communications

authors： Fukuroda T,Noguchi K,Tsuchida S,Nishikibe M,Ikemoto F,Okada K,Yano M

更新日期：1990-10-30 00:00:00

abstract：:To further extend the previous analysis of cis-acting elements and cognate trans-acting factors that contribute to GM-CSF transcriptional regulations, we have examined a promoter region between -1742 and -2010. DNase I footprinting assays showed four protected sequences named A, B, C and D. DNA transfections in the T-...

journal_title：Biochemical and biophysical research communications

authors： Musso M,Ghiorzo P,Fiorentini P,Giuffrida R,Ciotti P,Garré C,Ravazzolo R,Bianchi-Scarrà G

更新日期：1996-06-05 00:00:00

abstract：:Synthesis of melanin starts from the conversion of L-tyrosine to 3,4-dihydroxyphenylalanine (L-dopa) and then the oxidation of L-dopa yields dopaquinone by tyrosinase. Therefore, tyrosinase inhibitors have been established as important constituents of depigmentation agents. Recently, polyhydroxystilbene compounds, whi...

journal_title：Biochemical and biophysical research communications

authors： Ohguchi K,Tanaka T,Kido T,Baba K,Iinuma M,Matsumoto K,Akao Y,Nozawa Y

更新日期：2003-08-08 00:00:00

abstract：:The MCF-7 human breast cancer cell line is routinely used as a model system for the study of ER+, estrogen-responsive human breast cancer. Although most investigators have found these cells to be estrogen-responsive, there are reports that some stocks of MCF-7 cells may be either insensitive or may display decreased s...

journal_title：Biochemical and biophysical research communications

authors： Klotz DM,Castles CG,Fuqua SA,Spriggs LL,Hill SM

更新日期：1995-05-16 00:00:00

abstract：:Experimental gene transfer has permitted a wide variety of studies on gene regulation and function. However, possible effects of the introduced DNA on cellular metabolism are not well understood. Here we demonstrated that introduction of DNA into a promonocytic cell line, U937, by electroporation caused extensive cell...

journal_title：Biochemical and biophysical research communications

authors： Shimokawa T,Okumura K,Ra C

更新日期：2000-04-02 00:00:00

abstract：:The P-type ATPases affected in Menkes and Wilson diseases, ATP7A and ATP7B, respectively, are key copper transporters that regulate copper homeostasis. The N termini of these proteins are critical in regulating their function and activity, and contain six copper-binding motifs MxCxxC. In this study, we describe the id...

journal_title：Biochemical and biophysical research communications

authors： Lim CM,Cater MA,Mercer JF,La Fontaine S

更新日期：2006-09-22 00:00:00

abstract：:A monoclonal antibody, highly selective for the 5'-phosphopyridoxyl group, can be used to detect cytosolic pyridoxal-5'-phosphate binding proteins by an immunoblot procedure. This technique, when applied to sodium borohydride-treated cytosolic extracts obtained from normal rat liver at various stages of development as...

journal_title：Biochemical and biophysical research communications

authors： Kittler JM,Viceps-Madore D,Cidlowski JA,Thanassi JW

更新日期：1983-04-15 00:00:00

abstract：:The cell number as well as the hexokinase and glucokinase activity of liver parenchymal and nonparenchymal cells were studied in methapyrilene treated rats. The number of nonparenchymal cells was doubled after treatment with methapyrilene for two weeks while that of hepatocytes remained constant. The hexokinase activi...

journal_title：Biochemical and biophysical research communications

authors： Fischer W,Wagle SR,Katz NR

更新日期：1983-09-30 00:00:00

abstract：:Our laboratory demonstrated that endoplasmic reticulum iPLA2 (ER-iPLA2) activity protects renal cells from oxidant-induced cell death and lipid peroxidation. The goals of this study were to determine the PLA2 isoform(s) responsible for ER-iPLA2 activity in different species and tissues. ER-iPLA2 activity was observed ...

journal_title：Biochemical and biophysical research communications

authors： Kinsey GR,Cummings BS,Beckett CS,Saavedra G,Zhang W,McHowat J,Schnellmann RG

更新日期：2005-02-04 00:00:00

abstract：:Using baculoviral and bacterial systems, we expressed biologically active recombinant rat IL-13 and generated neutralizing rat IL-13 antiserum. Recombinant rat IL-13 produced by baculovirus-infected insect cells stimulated proliferation of TF-1 premyeloid cell line and induced expression of 15-lipoxygenase mRNA in hum...

journal_title：Biochemical and biophysical research communications

authors： Lakkis FG,Cruet EN,Nassar GM,Badr KF,Pascual DW

更新日期：1997-06-27 00:00:00

abstract：:To search autoantigens in autoimmune pancreatitis (AIP), we have screened the human pancreas cDNA library with a patient's serum and obtained 10 positive clones. Seven out of 10 clones were amylase alpha-2A, the autoantibody to which was specifically detected in sera from patients with AIP and fulminant type 1 diabete...

journal_title：Biochemical and biophysical research communications

authors： Takizawa S,Endo T,Wanjia X,Tanaka S,Takahashi M,Kobayashi T

更新日期：2009-08-14 00:00:00

abstract：:The 5'-flanking region of the human poly(ADP-ribose) polymerase gene was isolated and characterized. The nucleotide sequence of a part of the poly(ADP-ribose) polymerase gene completely matched that of the cDNA. The transcriptional initiation sites (cap sites) of this gene, located about 166-bp upstream from the trans...

journal_title：Biochemical and biophysical research communications

authors： Ogura T,Nyunoya H,Takahashi-Masutani M,Miwa M,Sugimura T,Esumi H

更新日期：1990-03-16 00:00:00

abstract：:Peptides simultaneously produced during maturation and degradation of peptidergic hormones and functional proteins have recently become a great interest because they display unpredictably different biological roles than the parent proteins. Namely, we discovered two novel functional cryptic peptides, mitocryptide-1 (M...

journal_title：Biochemical and biophysical research communications

authors： Seki T,Fukamizu A,Kiso Y,Mukai H

更新日期：2011-01-07 00:00:00

abstract：:We initiated the present work as part of an effort to identify and characterize genes from the EST2-HMG14 region from human chromosome 21 potentially responsible for some of the Down syndrome (DS) features. Genomic sample sequencing with cosmid clone A1047 located in the ETS2-HMG14 region of chromosome 21 has led to t...

journal_title：Biochemical and biophysical research communications

authors： Vidal-Taboada JM,Sanz S,Egeo A,Scartezzini P,Oliva R

更新日期：1998-09-29 00:00:00

abstract：:The initiating factors in primary, idiopathic osteoarthritis are unknown, the characteristic bone and cartilage changes being late features of the disease. We have proposed that biochemical cruciate ligament alteration may be important in early osteoarthritis by mediating loading consequences on the bone and cartilage...

journal_title：Biochemical and biophysical research communications

authors： Anderson-MacKenzie JM,Billingham ME,Bailey AJ

更新日期：1999-05-19 00:00:00

abstract：:Professional phagocytes contain a unique NADPH oxidase responsible for the production of microbicidal oxidants. Activation of this oxidase requires participation of cytosolic and membrane proteins, but the interactions of these components are incompletely understood. Patients with autosomal recessive Chronic Granuloma...

journal_title：Biochemical and biophysical research communications

authors： Levy R,Malech HL,Rotrosen D

更新日期：1990-08-16 00:00:00

abstract：:Soluble guanylyl cyclase (sGC) is activated by nitric oxide (NO) and generates the second messenger cyclic GMP (cGMP). Recently, purified sGC α1β1 has been shown to additionally generate the cyclic pyrimidine nucleotides cCMP and cUMP. However, since cyclic pyrimidine nucleotide formation occurred only the presence of...

journal_title：Biochemical and biophysical research communications

authors： Bähre H,Danker KY,Stasch JP,Kaever V,Seifert R

更新日期：2014-01-24 00:00:00

abstract：:Methylene blue (MB) is a blue cationic thiazine dye and currently used in different medical settings. Notably, there have been several attempts to introduce MB for attenuating pain in the last decade. Some clinical studies reported remarkable results, which, however, have been much debated. In addition, accumulating e...

journal_title：Biochemical and biophysical research communications

authors： Lee SW,Moon SW,Park JS,Suh HR,Han HC

更新日期：2021-01-16 00:00:00

abstract：:Autophagy is a physiologically regulated and evolutionary conserved process that plays a critical role in degradation of cytoplasmic proteins and other macromolecules within the lysosomes. Beclin-1, the mammalian orthologue of yeast Atg6, is an important mediator of autophagy that has been studied in many human cancer...

journal_title：Biochemical and biophysical research communications

authors： Kapoor V,Paliwal D,Baskar Singh S,Mohanti BK,Das SN

更新日期：2012-06-15 00:00:00

abstract：:Small ubiquitin-like modifiers (SUMOs) are proteins homologous to ubiquitin that possibly regulate intranuclear protein localization, nuclear transport, and ubiquitination. We examined patients of DRPLA, SCA1, MJD, and Huntington's disease and found that neurons in affected regions of the brain react strongly to SUMO-...

journal_title：Biochemical and biophysical research communications

authors： Ueda H,Goto J,Hashida H,Lin X,Oyanagi K,Kawano H,Zoghbi HY,Kanazawa I,Okazawa H

更新日期：2002-04-26 00:00:00

abstract：:Free fatty acids (FFAs) act as extracellular signaling molecules through binding to G-protein-coupled FFA receptors (FFARs). GPR120 and GPR40 are identified as FFARs for medium- and long-chain fatty acids. In the present study, we investigated roles of GPR120 and GPR40 in cellular functions of pancreatic cancer PANC-1...

journal_title：Biochemical and biophysical research communications

authors： Fukushima K,Yamasaki E,Ishii S,Tomimatsu A,Takahashi K,Hirane M,Fukushima N,Honoki K,Tsujiuchi T

更新日期：2015-09-25 00:00:00

abstract：BACKGROUND:The activation of hepatic stellate cells plays a central role in the development of liver fibrosis during chronic liver trauma. The aim of the present study was to identify a compound that inhibits the activation process of stellate cells. METHODS:Rat primary cultured stellate cells and a human stellate cel...

journal_title：Biochemical and biophysical research communications

authors： Cui W,Wang M,Maegawa H,Teranishi Y,Kawada N

更新日期：2012-08-31 00:00:00

abstract：:The NC1 domains from the different α(IV) collagen chains were found to exert anti-tumorigenic and/or anti-angiogenic activities. A limitation to the therapeutic use of these matrikines is the large amount of purified recombinant proteins, in the milligram range in mice that should be administered daily throughout the ...

journal_title：Biochemical and biophysical research communications

authors： Thevenard J,Ramont L,Mir LM,Dupont-Deshorgue A,Maquart FX,Monboisse JC,Brassart-Pasco S

更新日期：2013-03-22 00:00:00

abstract：:Using genomic restriction analysis of 14 unrelated patients with salt-losing congenital adrenal hyperplasia, we identified three different CA21HB mutation patterns: no detectable restriction fragment abnormalities (16/28 haplotypes), deletion of the active CA21HB gene (9/28), and apparent conversion of the active CA21...

journal_title：Biochemical and biophysical research communications

authors： Jospe N,Donohoue PA,Van Dop C,McLean RH,Bias WB,Migeon CJ

更新日期：1987-02-13 00:00:00

abstract：:The current studies were designed to explore the effects of C-receptor-binding atrial natriuretic peptide analogues on serum-induced mitogenesis in cultured rat aortic smooth muscle cells. To this end, rANF99-126 and a series of truncated (rANF103-126, rANF103-125), ring-deleted (des[Gln116, Ser117, Gly118, Leu119, Gl...

journal_title：Biochemical and biophysical research communications

authors： Cahill PA,Hassid A

更新日期：1991-09-30 00:00:00

abstract：:Phosphofructokinase (PFK) from human polymorphonuclear leukocytes (PMN) was characterized by immunological titration with subunit specific antibodies, column chromatography on QAE-Sephadex and SDS-polyacrylamide gel electrophoresis. Two different isozymes, M-type and L-type, were found. The M(r) values of the M and L ...

journal_title：Biochemical and biophysical research communications

authors： Durante P,Raleigh X,Gómez ME,Campos G,Ryder E

更新日期：1995-11-22 00:00:00

abstract：:Histamine H3 receptor (H3R), one of G protein-coupled receptors (GPCRs), has been known to regulate neurotransmitter release negatively in central and peripheral nervous systems. Recently, a variety of intracellular proteins have been identified to interact with carboxy (C)-termini of GPCRs, and control their intracel...

journal_title：Biochemical and biophysical research communications

authors： Maeda K,Haraguchi M,Kuramasu A,Sato T,Ariake K,Sakagami H,Kondo H,Yanai K,Fukunaga K,Yanagisawa T,Sukegawa J

更新日期：2008-05-02 00:00:00

abstract：:This report describes the in vivo phosphorylation of isocitrate lyase and examines the possible consequences to the control of the Kreb's cycle and glyoxylate bypass. NADP-specific isocitrate dehydrogenase from E. coli was the first bacterial protein whose enzymic activity was shown to be modulated by reversible phosp...

journal_title：Biochemical and biophysical research communications

authors： Hoyt JC,Reeves HC

更新日期：1988-06-16 00:00:00

abstract：:Intracellular B(12) metabolism involves a B(12) trafficking chaperone CblC that is well conserved in mammals including human. The protein CblC is known to bind cyanocobalamin (CNCbl, vitamin B(12)) inducing the base-off transition and convert it into an intermediate that can be used in enzyme cofactor synthesis. The b...

journal_title：Biochemical and biophysical research communications

authors： Jeong J,Kim J

更新日期：2011-08-26 00:00:00