Characterization of a putative promoter region of the human poly(ADP-ribose) polymerase gene: structural similarity to that of the DNA polymerase beta gene.

abstract：:A protein of M(r) 59,000 (p59) was recently cloned and identified as a Heat shock protein Binding Immunophilin (p59/HBI). It participates to the heterooligomeric, non-DNA binding form of steroid receptors, in association with the heat shock protein of M(r) 90,000 (hsp90). It binds the immunosuppressants FK506 and rapa...

journal_title：Biochemical and biophysical research communications

authors： Le Bihan S,Renoir JM,Radanyi C,Chambraud B,Joulin V,Catelli MG,Baulieu EE

更新日期：1993-09-15 00:00:00

abstract：:Signaling and desensitization of G protein-coupled receptor are intimately related, and measuring them separately requires certain parameters that represent desensitization independently of signaling. In this study, we tested whether desensitization requires signaling in three different receptors, beta2-adrenergic rec...

journal_title：Biochemical and biophysical research communications

authors： Barak LS,Gilchrist J,Becker JM,Kim KM

更新日期：2006-01-13 00:00:00

abstract：:To maintain immune homeostasis in the intestine, the intestinal immune system has evolved several tolerogenic mechanisms toward intestinal microflora and food antigens. Although programmed cell death-1 (PD-1) protein has been implicated in immunological tolerance in the intestine and gut-associated lymphoid tissues (G...

journal_title：Biochemical and biophysical research communications

authors： Doi T,Kanai T,Mikami Y,Sujino T,Jun L,Ono Y,Hayashi A,Hibi T

更新日期：2012-09-07 00:00:00

abstract：:The human Ube2J2 enzyme functions in the ubiquitination of proteins at the ER. Here we demonstrate that it, and a second ubiquitin conjugating (Ubc) enzyme Ube2G2, are unstable, and incubation of transfected cells with proteasome inhibitors increased steady-state protein levels. For Ube2J2, pharmacological induction o...

journal_title：Biochemical and biophysical research communications

authors： Lam SY,Murphy C,Foley LA,Ross SA,Wang TC,Fleming JV

更新日期：2014-08-29 00:00:00

abstract：:MicroRNAs (miRNAs) play critical roles in the proliferation of bovine preadipocytes. miR-2400 is a novel and unique miRNA from bovines. In the present study, we separated and identified preadipocytes from bovine samples. miR-2400 overexpression increased the rate of preadipocyte proliferation, which was analyzed with ...

journal_title：Biochemical and biophysical research communications

authors： Wei Y,Cui YF,Tong HL,Zhang WW,Yan YQ

更新日期：2016-09-23 00:00:00

abstract：:We studied the effects of interleukin-6(IL-6) on DNA synthesis and cyclic AMP production in rat thyroid FRTL-5 cells. When cells were incubated with IL-6 in the presence or absence of IGF-I, cell proliferation was not observed. By contrast, IL-6 stimulated DNA synthesis in a dose dependent manner when TSH was added co...

journal_title：Biochemical and biophysical research communications

authors： Nishiyama S,Takada K,Tada H,Takano T,Amino N

更新日期：1993-04-15 00:00:00

abstract：:Pigment epithelial-derived factor (PEDF) is a multifunctional secreted glycoprotein, which could protect against hypoxia-induced cell death related to its anti-oxidative effect in cultured cardiomyocytes. However, the pathway mediating this cytoprotective process has not been fully established. Here we confirmed that ...

journal_title：Biochemical and biophysical research communications

authors： Wang X,Zhang Y,Lu P,Zhang H,Li Y,Dong H,Zhang Z

更新日期：2015-09-25 00:00:00

abstract：:The major bovine seminal plasma protein, PDC-109, binds to choline phospholipids of the sperm plasma membrane and induces an efflux of cholesterol and choline phospholipids (cholesterol efflux), which is crucial for sperm capacitation. PDC-109 also exhibits chaperone-like activity and protects target proteins against ...

journal_title：Biochemical and biophysical research communications

authors： Singh BP,Saha I,Nandi I,Swamy MJ

更新日期：2017-12-02 00:00:00

abstract：:Alveolar epithelial type II cells (ATII cells) are the main target cells being damaged and releasing the inflammatory mediators during acute respiratory distress syndrome (ARDS). Extensive apoptosis of epithelial cells leads to the breakdown of the alveolar-epithelial barrier in ARDS. Cyclooxygenase-2 (COX-2) plays an...

journal_title：Biochemical and biophysical research communications

authors： Sun J,Zheng S,Yang N,Chen B,He G,Zhu T

更新日期：2019-09-10 00:00:00

abstract：:Neurogenin-3 (ngn-3) expression is critical for endocrine development in the developing pancreas. We found that when ngn-3 was inhibited in an E11.5 pancreas, using either morpholino antisense or siRNA, it led to a significant decrease in endocrine differentiation after seven days in culture. Endocrine differentiation...

journal_title：Biochemical and biophysical research communications

authors： Prasadan K,Tulachan S,Guo P,Shiota C,Shah S,Gittes G

更新日期：2010-06-11 00:00:00

abstract：:Adult T-cell leukemia (ATL)-related cells have the ability to produce a newly-isolated calcium-regulating protein, parathyroid hormone-related protein (PTHrP). The present study revealed that lectin-stimulated normal lymphocytes produce immunoreactive (IR)-PTHrP. When the T-cell-enriched fraction was purified from nor...

journal_title：Biochemical and biophysical research communications

authors： Adachi N,Yamaguchi K,Miyake Y,Honda S,Nagasaki K,Akiyama Y,Adachi I,Abe K

更新日期：1990-02-14 00:00:00

abstract：:Invaison plasmid antigen D (IpaD) and water-extracted outer-membrane proteins (OMPs) from Shigella flexneri were used to investigate some of the structural relationships of this pathogen's invasions. Extracellular presentation of the three invasion plasmid antigens (Ipa) B, C, and D is required for the S. flexneri inv...

journal_title：Biochemical and biophysical research communications

authors： Marquart ME,Picking WL,Picking WD

更新日期：1995-09-25 00:00:00

abstract：:CD36 expressed on adipocytes is thought to function as a fatty acid transporter (FAT). Here we report that adipocytes can endocytose and lysosomally degrade OxLDL, mainly mediated by CD36. Mouse 3T3-L1 preadipocytes showed marked increase in uptake and degradation of (125)I-OxLDL during their differentiation to adipoc...

journal_title：Biochemical and biophysical research communications

authors： Kuniyasu A,Hayashi S,Nakayama H

更新日期：2002-07-12 00:00:00

abstract：:The ability of two 15-ketosubstituted sterols, 5alpha-cholest-8(14)-en-3beta-ol-15-one and 3beta-(2-hydroxyethoxy)-5alpha-cholest-8(14)-en-15-one, to alter the mRNA levels of 3-hydroxy-3-methylglutaryl-CoA reductase, low density lipoprotein receptor, and oxysterol binding protein was studied and compared with the effe...

journal_title：Biochemical and biophysical research communications

authors： Kisseleva AF,Goryunova LE,Planells R,Lafont H,Alquier C

更新日期：1999-06-16 00:00:00

abstract：:The present study has focused on the role of the 42- and 44-kDa mitogen-activated protein kinases (p42/44 MAPKs) and the 38-kDa mitogen-activated protein kinase (p38 MAPK) in the proliferation of the pancreatic beta-cell line MIN6. MIN6 beta-cell proliferation was assessed by measuring 5-bromo-2'-deoxyuridine (BrdU) i...

journal_title：Biochemical and biophysical research communications

authors： Burns CJ,Squires PE,Persaud SJ

更新日期：2000-02-16 00:00:00

abstract：:Cardiac fibrosis is an important cardiac remodeling event in the development of inflammation dilated cardiomyopathy （iDCM）. We have previously observed that degradation enhancer of androgen receptor (ASC-J9®) could improve cardiac inflammation and fibrosis. Using Primary CFs, we demonstrated that ASC-J9® attenuates th...

journal_title：Biochemical and biophysical research communications

authors： Wang Y,Ma W,Lu S,Yan L,Hu F,Wang Z,Cheng B

更新日期：2018-11-17 00:00:00

abstract：:We have recently isolated a neural tissue-specific syntaxin-1-binding protein, named tomosyn, which is capable of dissociating Munc18/n-Sec1/rbSec1 from syntaxin-1 to form a 10S tomosyn complex, an intermediate complex converted to the 7S SNARE complex. We isolated here two splicing variants of tomosyn: one had 36 ami...

journal_title：Biochemical and biophysical research communications

authors： Yokoyama S,Shirataki H,Sakisaka T,Takai Y

更新日期：1999-03-05 00:00:00

abstract：:CHFR ubiquitin ligase acts as a checkpoint upon DNA damage and its functional inactivation is one of key characteristics of tumor development and metastasis. Despite the crucial role in maintaining genome integrity and cell cycle progression, little is known how CHFR stability is regulated. Here, we showed that CHFR i...

journal_title：Biochemical and biophysical research communications

authors： Kwon YE,Bae SJ,Kim M,Seol JH

更新日期：2013-01-04 00:00:00

abstract：:Communication between receptor tyrosine kinase and G protein-coupled receptor (GPCR)-mediated signaling is recognized as a common integrator linking diverse aspects of intracellular signaling systems. Here, we report that G protein-coupled beta-adrenergic receptor activation leading to stimulation of salivary phosphol...

journal_title：Biochemical and biophysical research communications

authors： Slomiany BL,Slomiany A

更新日期：2004-05-21 00:00:00

abstract：:The signal transduction of human 12(S)-lipoxygenase and the regulation of gene activation, induced by epidermal growth factor (EGF), are discussed in this review article. Treatment of human epidermoid carcinoma A431 cells with EGF induces the gene expression of human 12(S)-lipoxygenase, and two Sp1 binding sites resid...

journal_title：Biochemical and biophysical research communications

authors： Chang WC,Chen BK

更新日期：2005-12-09 00:00:00

abstract：:Prostaglandins are known to be involved in bone metabolism as evidenced by the ability of PGE2 to induce bone resorption. It was, therefore, of interest to determine if there was an association of specific prostaglandin metabolites with the various stages of developing bone by utilizing the matrix-induced endochondral...

journal_title：Biochemical and biophysical research communications

authors： Wientroub S,Wahl LM,Feuerstein N,Winter CC,Reddi AH

更新日期：1983-12-28 00:00:00

abstract：:Previously, we have demonstrated evidence suggesting that SUMO4 negatively regulates NFkappaB transcriptional activity, probably through sumoylation of IkappaBalpha. Here, we present data indicating that SUMO4 possesses the capacity to conjugate to IkappaBalpha. Luciferase reporter assays in 3T3 cells deficient for Ik...

journal_title：Biochemical and biophysical research communications

authors： Wang CY,Yang P,Li M,Gong F

更新日期：2009-04-17 00:00:00

abstract：:The interaction between the receptor (Rc) for atrial natriuretic peptide (ANP) and the effector enzyme particulate guanylate cyclase (GC) has been studied by radiation inactivation. Irradiation of bovine lung membranes produced an increase in GC activity at low radiation doses followed by a dose-dependent reduction at...

journal_title：Biochemical and biophysical research communications

authors： Ohuchi S,Hagiwara H,Ishido M,Fujita T,Kume T,Ishigaki I,Hirose S

更新日期：1989-01-31 00:00:00

abstract：:Recently, two reports [R. E. Davis et al. (1997) Proc. Natl. Acad. Sci. USA 94, 4564-4569 and E. Fahy et al. (1997) Nucleic Acids Res. 25, 3102-3109] described a series of heteroplasmic mitochondrial DNA (mtDNA) mutations in the genes encoding two cytochrome c oxidase subunits (CO1 and CO2) which segregated in higher ...

journal_title：Biochemical and biophysical research communications

authors： Davis JN 2nd,Parker WD Jr

更新日期：1998-03-27 00:00:00

abstract：:Having ascertained using JC-1 as a probe that, in distinction with the controls, during capacitation boar sperm maintains high mitochondrial membrane potential (ΔΨ), to gain some insight into the role of mitochondria in capacitation, we monitored ΔΨ generation due to externally added metabolites either in hypotonicall...

journal_title：Biochemical and biophysical research communications

authors： Paventi G,Lessard C,Bailey JL,Passarella S

更新日期：2015-07-03 00:00:00

abstract：:Ischemic stroke is one of major causes of adult morbidity. Recent studies have shown that over-activated microglial cells play a critical role in aggravating cerebral oxygen glucose deprivation/reoxygenation (OGD/R) damage by releasing excessive inflammatory cytokines. However, the involving mechanisms are not distinc...

journal_title：Biochemical and biophysical research communications

authors： Wen Y,Yu Y,Fu X

更新日期：2017-06-10 00:00:00

abstract：:The classification of molecular subtypes of breast cancer improves the prognostic accuracy and therapeutic benefits in clinic. However, because of the complexity of breast cancer, more biomarkers and functional molecules need to be explored. Here, analyzing the data in a huge cohort of breast cancer patients, we found...

journal_title：Biochemical and biophysical research communications

authors： Hua W,Sa KD,Zhang X,Jia LT,Zhao J,Yang AG,Zhang R,Fan J,Bian K

更新日期：2015-08-07 00:00:00

abstract：:Negative regulator of differentiation 1 (Nrd1) is known as a negative regulator of sexual differentiation in fission yeast. Recently, it has been revealed that Nrd1 also regulates cytokinesis, in which physical separation of the cell is achieved by a contractile ring comprising many proteins including actin and myosin...

journal_title：Biochemical and biophysical research communications

authors： Kobayashi A,Kanaba T,Satoh R,Fujiwara T,Ito Y,Sugiura R,Mishima M

更新日期：2013-07-19 00:00:00

abstract：:The proliferation promoting activity of various proteolytic fragments of human plasma fibronectin was assayed. Study of this activity in fragments, purified by affinity chromatography, has shown that only heparin-binding fragments were capable of promoting fibroblast proliferation while gelatin- and fibrin-binding fra...

journal_title：Biochemical and biophysical research communications

authors： Zlatopolsky AD,Chubukina AN,Berman AE

更新日期：1992-03-16 00:00:00

abstract：:Almost all bacteria require iron for growth and virulence expression. However, Listeria spp. do not produce any siderophore for iron acquisition. Representative strains of each of the six species of Listeria were examined for their ability to use various compounds as iron suppliers in iron-restricted medium. Here we s...

journal_title：Biochemical and biophysical research communications

authors： Coulanges V,Andre P,Vidon DJ

更新日期：1998-08-19 00:00:00