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Inhibition of the activation of hepatic stellate cells by arundic acid via the induction of cytoglobin.

Abstract：

BACKGROUND:The activation of hepatic stellate cells plays a central role in the development of liver fibrosis during chronic liver trauma. The aim of the present study was to identify a compound that inhibits the activation process of stellate cells. METHODS:Rat primary cultured stellate cells and a human stellate cell line (LX-2) were used. The effects of arundic acid on the expression of α-smooth muscle actin, collagen 1α1, and cytoglobin were evaluated. RESULTS:Arundic acid (300 μM) inhibited the activation of primary rat stellate cells, as determined by morphological transformation and α-smooth muscle actin expression, after both prophylactic and therapeutic treatment. The level of α-smooth muscle actin mRNA showed a dose-dependent decrease in response to arundic acid, and 50 μM arundic acid exhibited the maximum inhibition of collagen 1α1 mRNA expression. In contrast, arundic acid triggered an unexpected increase in mRNA and protein levels of cytoglobin, the fourth globin in mammals expressed exclusively in hepatic stellate cells. The effect of arundic acid on the level of α-smooth muscle actin mRNA was abrogated in HSCs treated with cytoglobin siRNA. Arundic acid decreased the expression of collagen 1α1 mRNA in LX-2 cells. CONCLUSION:Arundic acid affects the activation process of hepatic stellate cells via the unexpected induction of cytoglobin.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Cui W,Wang M,Maegawa H,Teranishi Y,Kawada N

doi

10.1016/j.bbrc.2012.07.126

subject

Has Abstract

pub_date

2012-08-31 00:00:00

pages

642-8

issue

3

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(12)01433-7

journal_volume

425

pub_type

杂志文章

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