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Unique CCT repeats mediate transcription of the TWIST1 gene in mesenchymal cell lines.

Abstract：

:TWIST1, a basic helix-loop-helix transcription factor, plays critical roles in embryo development, cancer metastasis and mesenchymal progenitor differentiation. Little is known about transcriptional regulation of TWIST1 expression. Here we identified DNA sequences responsible for TWIST1 expression in mesenchymal lineage cell lines. Reporter assays with TWIST1 promoter mutants defined the -102 to -74 sequences that are essential for TWIST1 expression in human and mouse mesenchymal cell lines. Tandem repeats of CCT, but not putative CREB and NF-kappaB sites in the sequences substantially supported activity of the TWIST1 promoter. Electrophoretic mobility shift assay demonstrated that the DNA sequences with the CCT repeats formed complexes with nuclear factors, containing, at least, Sp1 and Sp3. These results suggest critical implication of the CCT repeats in association with Sp1 and Sp3 factors in sustaining expression of the TWIST1 gene in mesenchymal cells.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Ohkuma M,Funato N,Higashihori N,Murakami M,Ohyama K,Nakamura M

doi

10.1016/j.bbrc.2006.11.114

subject

Has Abstract

pub_date

2007-01-26 00:00:00

pages

925-31

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(06)02608-8

journal_volume

352

pub_type

杂志文章

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