Digeranyl bisphosphonate inhibits geranylgeranyl pyrophosphate synthase.

abstract：:In continuation of our recent observations indicating the presence of a lone calcineurin-dependent response element (CDRE) in the -3730bp upstream region of copper-induced metallothionein (CuMT) gene of Neurospora [K.S. Kumar, S. Dayananda, C. Subramanyam, Copper alone, but not oxidative stress, induces copper-metallo...

journal_title：Biochemical and biophysical research communications

authors： Kumar KS,Ravi Kumar B,Siddavattam D,Subramanyam C

更新日期：2006-07-07 00:00:00

abstract：:The mouse NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH) gene and its 5'-flanking region was cloned from a 129 mouse ES bacteriophage P1 genomic library. The gene contains 7 exons and 6 introns and is 11.3 kb in length. The transcription initiation site was mapped at 35 bases upstream from the ATG star...

journal_title：Biochemical and biophysical research communications

authors： Matsuo M,Ensor CM,Tai HH

更新日期：1997-06-27 00:00:00

abstract：:Mouse thymocytes were separated into cortical and medullary subpopulations by differential agglutination with peanut agglutinin. A high-affinity receptor for 1,25-dihydroxyvitamin D3 is present in medullary immunocompetent mouse thymocytes and is absent from cortical immature cells. 1,25-dihydroxyvitamin D3, at physio...

journal_title：Biochemical and biophysical research communications

authors： Ravid A,Koren R,Novogrodsky A,Liberman UA

更新日期：1984-08-30 00:00:00

abstract：:Effects of hepatocyte growth factor (HGF) on gastric wound repair were assessed. Artificial wounds of uniform size were made by mechanical cell denudation in confluent rabbit gastric mucosal cell sheets. The changes in wound size were analyzed quantitatively. The wound repair process contained an initial migration sta...

journal_title：Biochemical and biophysical research communications

authors： Watanabe S,Hirose M,Wang XE,Maehiro K,Murai T,Kobayashi O,Nagahara A,Sato N

更新日期：1994-03-30 00:00:00

abstract：:Groucho is a protein implicated in Notch signaling and involved in segmentation and neural development in Drosophila. Groucho forms transcription complexes with the basic helix-loop-helix proteins encoded by the hairy/Enhancer of split ("hairy-like") gene family. These interactions are mediated by the carboxyl-termina...

journal_title：Biochemical and biophysical research communications

authors： Grbavec D,Stifani S

更新日期：1996-06-25 00:00:00

abstract：:The intrinsic fluorescence properties of human alpha apohemoglobin at protein concentrations from 1 to 5 microM in 0.1 M potassium phosphate buffer, pH 7 or 8 at 5 degrees C were monitored in the absence and presence of a fixed concentration (5 microM) of a fluorescence quenching heme-containing native or Des (146-His...

journal_title：Biochemical and biophysical research communications

authors： Chiu F,Vasudevan G,Morris A,McDonald MJ

更新日期：1998-01-14 00:00:00

abstract：:Mouse monoclonal antibodies were generated against human ribonuclease inhibitor, an intracellular regulatory protein. A total of four antibodies were isolated, all of which were of the immunoglobulin G1 subtype. Western blot analysis of the antibodies suggested monospecificity. Based on immunoradiometric competition a...

journal_title：Biochemical and biophysical research communications

authors： Feldman M,Kohtz DS,Kleinberg DL

更新日期：1988-11-30 00:00:00

abstract：:DJ-1, a product of the DJ-1/PARK7 gene, has been suggested to play various functions involved in transcriptional regulation, protease activity, anti-oxidative stress activity, and regulation of mitochondrial complex I. Such a variety of functions of DJ-1 are supposed to be realized through interactions with different ...

journal_title：Biochemical and biophysical research communications

authors： Yasuda T,Kaji Y,Agatsuma T,Niki T,Arisawa M,Shuto S,Ariga H,Iguchi-Ariga SM

更新日期：2013-06-28 00:00:00

abstract：:Streptococcus pneumoniae is a pathogenic bacterium that can cause severe invasive diseases, such as pneumonia, otitis media and meningitis. The pro-inflammatory cytokine, IL-1β, has been reported to play important role in host defense against S. pneumoniae. The mechanism of IL-1β maturation and secretion in macrophage...

journal_title：Biochemical and biophysical research communications

authors： Zhang T,Du H,Feng S,Wu R,Chen T,Jiang J,Peng Y,Ye C,Fang R

更新日期：2019-06-04 00:00:00

abstract：:Removal of parts of a known calmodulin binding site at the C-terminus of HIV-1 envelope glycoprotein, gp160, can result in diminished infectivity. We investigated whether expression of full length gp160 would result in changes in intracellular calmodulin compared to expression of gp160 truncated to remove both known c...

journal_title：Biochemical and biophysical research communications

authors： Radding W,Pan ZQ,Hunter E,Johnston P,Williams JP,McDonald JM

更新日期：1996-01-05 00:00:00

abstract：:A key feature of O2 sensing by chemoreceptor tissues is the hypoxic inhibition of K+ channels. However, mechanisms coupling a fall of pO2 to channel closure differ between tissues: O2 regulation of K+ channels in chemoreceptive neuroepithelial bodies and their immortal counterparts, H146 cells, involves altered reacti...

journal_title：Biochemical and biophysical research communications

authors： O'Kelly I,Peers C,Kemp PJ

更新日期：2001-05-25 00:00:00

abstract：:In this study of lectin-induced apoptosis we found that wheat germ agglutinin (WGA) initiated an accelerated type of programmed cell death developing after only 30 min of incubation with tumor cells. To analyze possible mechanisms, studies were focused using the WGA lectin whose carbohydrate specificity is well define...

journal_title：Biochemical and biophysical research communications

authors： Gastman B,Wang K,Han J,Zhu ZY,Huang X,Wang GQ,Rabinowich H,Gorelik E

更新日期：2004-03-26 00:00:00

abstract：:Keratoconus involves thinning and central protuberance of the cornea, scarring and significantly decreased vision. It is one of the major causes of corneal transplantation in this country, but the etiology of this disorder is unclear. In the present study stromal keratocytes were isolated and cultured from normal and ...

journal_title：Biochemical and biophysical research communications

authors： Kenney MC,Chwa M,Escobar M,Brown D

更新日期：1989-05-30 00:00:00

abstract：:By its antioxidant effect, molecular hydrogen gas (H2) was reported to protect organs from tissue damage induced by ischemia reperfusion. To evaluate its anti-inflammatory effects, we established a mouse model of human inflammatory bowel disease (IBD) by supplying mice with water containing (1) dextran sodium sulfate ...

journal_title：Biochemical and biophysical research communications

authors： Kajiya M,Silva MJ,Sato K,Ouhara K,Kawai T

更新日期：2009-08-14 00:00:00

abstract：:When TT virus (TTV) DNA was quantitated in whole blood and plasma aliquots from 27 viremic individuals by real-time detection PCR that can detect essentially all TTV genotypes, the TTV load was 6.9 +/- 3.5 (mean +/- standard deviation)-fold higher in the whole blood than in the plasma samples [P < 0.002 (paired t test...

journal_title：Biochemical and biophysical research communications

authors： Takahashi M,Asabe S,Gotanda Y,Kishimoto J,Tsuda F,Okamoto H

更新日期：2002-01-11 00:00:00

abstract：:Fluorescein 5'-isothiocyanate (FITC) was used to modify lysine residues of the strychnine-sensitive glycine receptor. Pretreatment of rat spinal cord synaptic plasma membranes with FITC specifically affected the ability of glycine to displace [3H]strychnine binding. Glycine completely prevented the effect of FITC modi...

journal_title：Biochemical and biophysical research communications

authors： Ruiz Gómez A,Fernández-Shaw C,Valdivieso F,Mayor F Jr

更新日期：1989-04-14 00:00:00

abstract：:The neuropeptide Y (NPY) system is known as one of the major neural signaling pathways. NPY, produced by peripheral tissues including osteoblasts, is known to bind to the Y1 receptor. Recently, osteoblast-specific Y1 receptor knockout mice were developed and were found to have a high bone mass phenotype, indicating a ...

journal_title：Biochemical and biophysical research communications

authors： Kurebayashi N,Sato M,Fujisawa T,Fukushima K,Tamura M

更新日期：2013-10-04 00:00:00

abstract：:The yeast transcriptional regulator Hap1 promotes both transcriptional activation and repression. Previous studies have shown that Hap1 binds to the promoter of its own gene and represses its transcription. In this report, we identified the DNA site that allows Hap1-binding with high affinity. This Hap1-binding site c...

journal_title：Biochemical and biophysical research communications

authors： Xin X,Lan C,Lee HC,Zhang L

更新日期：2007-10-12 00:00:00

abstract：BACKGROUND AND AIMS:Vector based over-expression of α-synuclein is a newly developed method to establish animal Parkinson's disease (PD) model. In this paper, we inject the rat brain with recombinant adeno-associated virus (rAAV) to express α-synuclein wild-type and A53T mutation, and compared the degeneration of dopam...

journal_title：Biochemical and biophysical research communications

authors： Lu J,Sun F,Ma H,Qing H,Deng Y

更新日期：2015-09-04 00:00:00

abstract：:The molecular mechanisms of multiple myeloma are not well defined. EEN is an endocytosis-regulating molecule. Here we report that EEN regulates the proliferation and survival of multiple myeloma cells, by regulating IGF-1 secretion. In the present study, we observed that EEN expression paralleled with cell proliferati...

journal_title：Biochemical and biophysical research communications

authors： Huang EW,Xue SJ,Li XY,Xu SW,Cheng JD,Zheng JX,Shi H,Lv GL,Li ZG,Li Y,Liu CH,Chen XH,Liu H,Li J,Liu C

更新日期：2014-05-02 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is a potent and specific mitogen for vascular endothelial cells. A 3.9 kb VEGF transcript is expressed by all cardiac tissues from rat, mouse and guinea pig examined. VEGF expression was not developmentally regulated. The major form of VEGF mRNAs expressed by cardiac tissues c...

journal_title：Biochemical and biophysical research communications

authors： Ladoux A,Frelin C

更新日期：1993-09-15 00:00:00

abstract：:Akt kinase-interacting protein 1 (Aki1)/Freud-1/CC2D1A is localized in the cytosol, nucleus, and centrosome. Aki1 plays distinct roles depending on its localization. In the cytosol, it acts as a scaffold protein in the phosphoinositide 3-kinase (PI3K)/3-phosphoinositide-dependent protein kinase 1 (PDK1)/Akt pathway. I...

journal_title：Biochemical and biophysical research communications

authors： Nakamura A,Naito M,Arai H,Fujita N

更新日期：2010-03-19 00:00:00

abstract：:Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a type II transmembrane cytokine and a potent inducer of apoptosis. Epidermal growth factor (EGF) signaling is well known to involve in tumor survival and overexpression of EGF receptor (EGF-R) attributes to decreased responsiveness to many avail...

journal_title：Biochemical and biophysical research communications

authors： Park SY,Seol DW

更新日期：2002-07-12 00:00:00

abstract：:Localization of ATP-binding cassette transporter isoform C1 (ABCC1) to the basolateral membrane of polarized cells is crucial for export of a variety of cellular metabolites; however, the mechanism regulating basolateral targeting of the transporter is poorly understood. Here we describe identification of a basolatera...

journal_title：Biochemical and biophysical research communications

authors： Emi Y,Harada Y,Sakaguchi M

更新日期：2013-11-08 00:00:00

abstract：:CD30, a member of the TNF receptor family, has been implicated in the activation of T cells and B cells. In the present study, we characterized the expression and function of murine CD30 ligand (mCD153) by utilizing mCD153 transfectants and a novel mAb against mCD153 (RM153), which can inhibit the binding of murine CD...

journal_title：Biochemical and biophysical research communications

authors： Shimozato O,Takeda K,Yagita H,Okumura K

更新日期：1999-03-24 00:00:00

abstract：:The main protein of enriched and purified amyloid from Octodon degus pancreatic islets was identified as insulin. The material was reduced and alkylated and the A- and the B-chain were separated by reversed phase chromatography and subjected to Edman degradation and amino acid analysis. It was shown that the A-chain c...

journal_title：Biochemical and biophysical research communications

authors： Hellman U,Wernstedt C,Westermark P,O'Brien TD,Rathbun WB,Johnson KH

更新日期：1990-06-15 00:00:00

abstract：:5'-RACE and genomic cloning were used to determine that the mouse TBP (mTBP) gene consists of one 5'-terminal non-coding exon followed by seven protein-coding exons. The region upstream of the first exon lacks a TATA-box. Hence, as with the case of other genes carrying TATA-less promoter, transcription starts from a c...

journal_title：Biochemical and biophysical research communications

authors： Ohbayashi T,Schmidt EE,Makino Y,Kishimoto T,Nabeshima Y,Muramatsu M,Tamura T

更新日期：1996-08-05 00:00:00

abstract：:Mab21 gene family members are required for embryonic development and sensory organ formation in both invertebrates and vertebrates. However, their mechanistic role on differentiation is largely unexplored. We report here the isolation of SIN-3 as a MAB-21 interacting molecule. sin-3 is co-expressed with mab-21 in the ...

journal_title：Biochemical and biophysical research communications

authors： Choy SW,Wong YM,Ho SH,Chow KL

更新日期：2007-07-06 00:00:00

abstract：:The fungal AAL-toxin triggers programmed cell death (PCD) through perturbations of sphingolipid metabolism in AAL-toxin-sensitive plants. While Arabidopsis is relatively insensitive to the toxin, the loh2 mutant exhibits increased susceptibility to AAL-toxin due to the knockout of a gene involved in sphingolipid metab...

journal_title：Biochemical and biophysical research communications

authors： Gechev TS,Ferwerda MA,Mehterov N,Laloi C,Qureshi MK,Hille J

更新日期：2008-10-31 00:00:00

abstract：:A protein of M(r) 59,000 (p59) was recently cloned and identified as a Heat shock protein Binding Immunophilin (p59/HBI). It participates to the heterooligomeric, non-DNA binding form of steroid receptors, in association with the heat shock protein of M(r) 90,000 (hsp90). It binds the immunosuppressants FK506 and rapa...

journal_title：Biochemical and biophysical research communications

authors： Le Bihan S,Renoir JM,Radanyi C,Chambraud B,Joulin V,Catelli MG,Baulieu EE

更新日期：1993-09-15 00:00:00