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Hydrogen mediates suppression of colon inflammation induced by dextran sodium sulfate.

Abstract：

:By its antioxidant effect, molecular hydrogen gas (H2) was reported to protect organs from tissue damage induced by ischemia reperfusion. To evaluate its anti-inflammatory effects, we established a mouse model of human inflammatory bowel disease (IBD) by supplying mice with water containing (1) dextran sodium sulfate (DSS) (5%), (2) DSS (5%) and H2, or (3) H2 only ad libitum up to 7 days. At day-7, DSS-induced pathogenic outcomes including, loss of body weight, increase of colitis score, pathogenic shortening of colon length, elevated level of IL-12, TNF-alpha and IL-1beta in colon lesion, were significantly suppressed by the addition of H2 to DSS solution. Histological analysis also revealed that the DSS-mediated colonic tissue destruction accompanied by macrophage infiltration was remarkably suppressed by H2. Therefore, the present study indicated that H2 can prevent the development of DSS-induced colitis in mice.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Kajiya M,Silva MJ,Sato K,Ouhara K,Kawai T

doi

10.1016/j.bbrc.2009.05.117

subject

Has Abstract

pub_date

2009-08-14 00:00:00

pages

11-5

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(09)01061-4

journal_volume

386

pub_type

杂志文章

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