Secretory granules from different glands contain neurocuprein-like protein.

abstract：:Apoptosis induced in primary cultures of rat hepatocytes by transforming growth factor beta 1 (TGF-beta 1) was greatly attenuated by inhibitors (5 microM) of calpain I and calpain II, respectively. Both inhibitors prevented the TGF-beta-elicited increase of nucleosomal DNA fragments and the occurrence of DNA-breaks in...

journal_title：Biochemical and biophysical research communications

authors： Gressner AM,Lahme B,Roth S

更新日期：1997-02-13 00:00:00

abstract：:ATP1B4 genes represent a rare instance of the orthologous gene co-option that radically changed functions of encoded BetaM proteins during vertebrate evolution. In lower vertebrates, this protein is a β-subunit of Na,K-ATPase located in the cell membrane. In placental mammals, BetaM completely lost its ancestral role ...

journal_title：Biochemical and biophysical research communications

authors： Pestov NB,Zhao H,Basrur V,Modyanov NN

更新日期：2011-09-09 00:00:00

abstract：:Calyculin A (CL-A), a toxin isolated from the marine sponge Discodermia calyx, is a strong inhibitor of protein phosphatase 1 (PP1) and 2A (PP2A). Although CL-A is known to induce rapid neurite retraction in developing neurons, the cytoskeletal dynamics of this retraction have remained unclear. Here, we investigated t...

journal_title：Biochemical and biophysical research communications

authors： Inutsuka A,Goda M,Fujiyoshi Y

更新日期：2009-12-25 00:00:00

abstract：:The target tissues of TCDD, the dysfunctions that result in death in experimental animals, and the ultimate biochemical lesion(s) caused by TCDD are not known despite numerous studies. We have shown by the thiobarbituric acid and conjugated diene methods that TCDD induces hepatic lipid peroxidation in rats. The lipid ...

journal_title：Biochemical and biophysical research communications

authors： Stohs SJ,Hassan MQ,Murray WJ

更新日期：1983-03-29 00:00:00

abstract：:In the areas of North Africa, Southeast Asia as well as South China, Nasopharyngeal carcinoma (NPC) is among the most widespread cancers. Plenty of research findings confirmed that Epstein-Barr virus (EBV) played a crucial role in NPC. EBV-encoded Latent membrane protein 2A (LMP2A) which continuously expressed in cell...

journal_title：Biochemical and biophysical research communications

authors： Cao Q,Zhang D,Mao Y,Meng C,Zhu J,Feng Z,Chen R

更新日期：2017-01-08 00:00:00

abstract：:B7-H3, an immunoregulatory protein, has been found highly expressed in several cancer types, and involved in cancer cell migration and invasion. Here, we investigated the role of B7-H3 in oxaliplatin resistance in colorectal cancer (CRC) cells. Transient silencing of B7-H3 enhanced oxaliplatin sensitivity by increasin...

journal_title：Biochemical and biophysical research communications

authors： Zhang P,Chen Z,Ning K,Jin J,Han X

更新日期：2017-08-26 00:00:00

abstract：:The distribution and intracellular translocation of AFB1 in various subcellular fractions was investigated in isolated hepatocytes by pulse-chase experiments. After labeling the hepatocytes with [3H]-AFB1 (14.5 nM) for 15 min, the highest concentration of [3H]-AFB1 was found in the cytosolic fraction where 66% was bou...

journal_title：Biochemical and biophysical research communications

authors： Ch'ih JJ,Devlin TM

更新日期：1984-07-18 00:00:00

abstract：:An internal RNA standard proved less suitable in bacterial gene expression experiments. We therefore developed a method for simultaneous RNA and gDNA (genomic DNA) isolation from in vitro and in vivo samples containing staphylococci and combined it with quantitative PCR. The reliability of gDNA for bacterial quantific...

journal_title：Biochemical and biophysical research communications

authors： Vandecasteele SJ,Peetermans WE,Merckx R,Van Ranst M,Van Eldere J

更新日期：2002-03-01 00:00:00

abstract：:Tumor necrosis factor (TNF)-α-inducing protein (Tipα) is a newly identified carcinogenic factor secreted by Helicobacter pylori (H. pylori). Although it has been proved that Tipα is a strong inducer of epithelial-mesenchymal transition (EMT), a crucial process of migration, the exact molecular mechanism is unknown. Cu...

journal_title：Biochemical and biophysical research communications

authors： Chen G,Tang N,Wang C,Xiao L,Yu M,Zhao L,Cai H,Han L,Xie C,Zhang Y

更新日期：2017-03-04 00:00:00

abstract：:Escherichia coli K1 is the most common gram-negative bacterium causing neonatal meningitis. The outer membrane protein A (OmpA) assembles a beta-barrel structure having four surface-exposed loops in E. coli outer membrane. OmpA of meningitis-causing E. coli K1 is shown to contribute to invasion of the human brain micr...

journal_title：Biochemical and biophysical research communications

authors： Shin S,Lu G,Cai M,Kim KS

更新日期：2005-05-20 00:00:00

abstract：:The structural changes of the F-actin-myosin head (S1) complex during the cross-bridge cycle are essential in muscle contraction. Although a large body of evidence has accumulated showing that the actin: S1 stoichiometry in the decorated F-actin-S1 filament is 1:1 at saturation by S1, a recent report by Andreev and Bo...

journal_title：Biochemical and biophysical research communications

authors： Carlier MF,Didry D

更新日期：1992-03-31 00:00:00

abstract：:Lectin-like oxidized low-density lipoprotein (oxLDL) receptor-1 (LOX-1) was originally identified as a receptor for oxLDL predominantly expressed in endothelial cells. Recently up-regulation of LOX-1 has been implicated in oxidative stress and cell apoptosis in many cell types. However, LOX-1 expression in neurons or ...

journal_title：Biochemical and biophysical research communications

authors： Li Y,Duan Z,Gao D,Huang S,Yuan H,Niu X

更新日期：2012-09-07 00:00:00

abstract：:PKCdelta was revealed to make a homologous protein complex that shows a high protein kinase activity upon H(2)O(2) stimulation by expressing the enzymes having different epitope tags in COS-7 cells. The association of the endogenous PKCdelta in the cells was observed by sucrose density gradients. Analysis using the mu...

journal_title：Biochemical and biophysical research communications

authors： Umada-Kajimoto S,Yamamoto T,Matsuzaki H,Kikkawa U

更新日期：2006-03-03 00:00:00

abstract：:NADPH oxidases (NOX) - derived reactive oxygen species (ROS) contribute to oxidative injury in hypoxia-induced pulmonary arterial hypertension. This study aims to evaluate the status of NOX in endothelial progenitor cells (EPCs) under hypoxic condition and to determine whether NOX inhibitors could attenuate hypoxia-in...

journal_title：Biochemical and biophysical research communications

authors： Liu B,Ren KD,Peng JJ,Li T,Luo XJ,Fan C,Yang JF,Peng J

更新日期：2017-01-22 00:00:00

abstract：:Glycosaminoglycans were prepared from the Engelbreth-Holm-Swarm mouse tumor. Enzymatic analysis demonstrated heparan sulfate (95.8%) and chondroitinase ABC-sensitive galactosaminoglycans (4.2%). HPLC analysis of the disaccharide units showed that heparan sulfate chains were undersulfated on average, comprising approxi...

journal_title：Biochemical and biophysical research communications

authors： Sugahara K,Okumura Y,Yamashina I

更新日期：1989-07-14 00:00:00

abstract：:The cardiovascular system operates under demands ranging from conditions of rest to extreme stress. One mechanism of cardiac stress tolerance is action potential duration shortening driven by ATP-sensitive potassium (K(ATP)) channels. K(ATP) channel expression has a significant physiologic impact on action potential d...

journal_title：Biochemical and biophysical research communications

authors： Zhu Z,Burnett CM,Maksymov G,Stepniak E,Sierra A,Subbotina E,Anderson ME,Coetzee WA,Hodgson-Zingman DM,Zingman LV

更新日期：2011-12-02 00:00:00

abstract：:We previously found a new endogenous factor in rat liver cytosol, named ATP-stimulated glucocorticoid-receptor translocation promoter (ASTP), that increased the binding of activated glucocorticoid-receptor to nuclei in the presence of ATP. We have cloned and sequenced a cDNA (2989 bp) encoding the ASTP protein. An ope...

journal_title：Biochemical and biophysical research communications

authors： Okamoto K,Hirano H,Isohashi F

更新日期：1993-06-30 00:00:00

abstract：:Hepatocyte growth factor, which is now known to be the same protein as scatter factor, induced oligonucleosomal fragmentation of nuclear DNA of Sarcoma 180 cells and increased the activity of caspase-3, a key component in control of the apoptotic cell death pathway to about 2.6 times that in control cells on 48 hr inc...

journal_title：Biochemical and biophysical research communications

authors： Arakaki N,Kazi JA,Kazihara T,Ohnishi T,Daikuhara Y

更新日期：1998-04-07 00:00:00

abstract：:The interaction of adrenodoxin (Adx) and NADPH cytochrome P450 reductase (CPR) with human microsomal steroidogenic cytochrome P450s was studied. It is found that Adx, mitochondrial electron transfer protein, is able to support reactions catalyzed by human microsomal P450s: full length CYP17, truncated CYP17, and trunc...

journal_title：Biochemical and biophysical research communications

authors： Pechurskaya TA,Harnastai IN,Grabovec IP,Gilep AA,Usanov SA

更新日期：2007-02-16 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta) is an inhibitor of the proliferation of bovine aortic endothelial cells in culture. Basal cell growth in serum-containing medium and cell proliferation stimulated by fibroblast growth factor (FGF) are inhibited by TGF-beta in a dose-dependent manner. Half-maximal inhibition o...

journal_title：Biochemical and biophysical research communications

authors： Fràter-Schröder M,Müller G,Birchmeier W,Böhlen P

更新日期：1986-05-29 00:00:00

abstract：:RNA polymerase III promoters of human ribonuclease P RNA component H1, human U6, and mouse U6 small nuclear RNA genes are commonly used in short hairpin RNA (shRNA) expression vectors due their precise initiation and termination sites. During transient transfection of shRNA vectors, we observed that H1 or U6 promoters...

journal_title：Biochemical and biophysical research communications

authors： Rumi M,Ishihara S,Aziz M,Kazumori H,Ishimura N,Yuki T,Kadota C,Kadowaki Y,Kinoshita Y

更新日期：2006-01-13 00:00:00

abstract：:We found that heparin at low concentrations increases the vascular endothelial growth factor (VEGF)-induced proliferation of human umbilical vein endothelial cells (HUVECs) but at high concentrations decreases it. To examine whether FLT-1, a VEGF receptor, interacts with heparin and which domain of FLT-1 binds to hepa...

journal_title：Biochemical and biophysical research communications

authors： Park M,Lee ST

更新日期：1999-11-02 00:00:00

abstract：:We have identified and characterized the novel human transmembrane protein 9 (TMEM9). TMEM9 encodes a 183 amino-acid protein that contains an N-terminal signal peptide, a single transmembrane region, three potential N-glycosylation sites, and three conserved cys-rich domains in the N-terminus, but no hitherto known fu...

journal_title：Biochemical and biophysical research communications

authors： Kveine M,Tenstad E,Døsen G,Funderud S,Rian E

更新日期：2002-10-04 00:00:00

abstract：:Multidrug resistance (MDR) is a unique phenomenon in cancer patients and is commonly associated with an overexpression of the human MDR gene mdr1, which encodes an energy-dependent Mr 180 kDa membrane bound protein, known as P-glycoprotein. P-glycoprotein serves as a membrane efflux to pump the drugs out of the cancer...

journal_title：Biochemical and biophysical research communications

authors： Chu TM,Lin TH,Kawinski E

更新日期：1994-08-30 00:00:00

abstract：:Mesenchymal stem cells (MSCs) have generated a great deal of interest in clinical situations, due principally to their potential use in regenerative medicine and tissue engineering applications. However, the therapeutic application of MSCs remains limited, unless the favorable effects of MSCs on tumor growth in vivo, ...

journal_title：Biochemical and biophysical research communications

authors： Shin KK,Lee AL,Kim JY,Lee SY,Bae YC,Jung JS

更新日期：2012-06-15 00:00:00

abstract：:Estrogen induces lordosis through, in part, estrogen receptor (ER)-mediated synthesis of progesterone receptors (PR) in the ventromedial nucleus (VMN). In vitro, PR is activated by the neurotransmitter dopamine through D1-like receptors (1). In vivo, lordosis is induced by dopamine, an effect mediated in part by PR an...

journal_title：Biochemical and biophysical research communications

authors： Zhou D,Apostolakis EM,O'Malley BW

更新日期：1999-12-20 00:00:00

abstract：:Human Niemann-Pick type II fibroblasts, which encompass the panethnic type C (NPC) and Nova Scotia Acadian type D (NPD) variants, exhibit altered expression of caveolin-1 protein when examined by immunoblotting using an anti-caveolin-1 monoclonal antibody. Unexpectedly, caveolin-1 in heterozygous fibroblasts was signi...

journal_title：Biochemical and biophysical research communications

authors： Garver WS,Hsu SC,Erickson RP,Greer WL,Byers DM,Heidenreich RA

更新日期：1997-07-09 00:00:00

abstract：:The kinetic parameters of several substrates of penicillin acylase from Streptomyces lavendulae have been determined. The enzyme hydrolyses phenoxymethyl penicillin (penicillin V) and other penicillins with aliphatic acyl-chains such as penicillin F, dihydroF, and K. The best substrate was penicillin K (octanoyl penic...

journal_title：Biochemical and biophysical research communications

authors： Torres-Guzmán R,de la Mata I,Torres-Bacete J,Arroyo M,Castillón MP,Acebal C

更新日期：2002-03-01 00:00:00

abstract：:Here we describe the cDNA structure, genomic organization, chromosomal localization, and promoter analysis of the mouse peptide transporter PEPT2. The PEPT2-cDNA is 3987 bp long and encodes a protein of 729 amino acids. The functional properties, analyzed by expression in Xenopus laevis oocytes, showed a typical PEPT2...

journal_title：Biochemical and biophysical research communications

authors： Rubio-Aliaga I,Boll M,Daniel H

更新日期：2000-09-24 00:00:00

abstract：:Determination of the rates of saccharide diffusions by the proteoliposomes showed that the outer membrane of Pseudomonas aeruginosa only possesses small diffusion pores and that protein F might have not been involved in the pore formation. Proteoliposomes containing stachyose or Dextan T-10 showed the same relative di...

journal_title：Biochemical and biophysical research communications

authors： Yoshihara E,Gotoh N,Nakae T

更新日期：1988-10-14 00:00:00