Adrenodoxin supports reactions catalyzed by microsomal steroidogenic cytochrome P450s.

abstract：:Placental choriocarcinoma, a reproductive system carcinoma in women, has about 0.81% occurrence frequency in China, which leads to over 90% lethality due to indistinct pathogenesis and the absence of efficient therapeutic treatment. In the present study, using immunostaining and reverse transcription PCR, we reported ...

journal_title：Biochemical and biophysical research communications

authors： Peng S,Miao C,Li J,Fan X,Cao Y,Duan E

更新日期：2006-11-24 00:00:00

abstract：:Hepatitis C virus (HCV), a hepacivirus member of the Flaviviridae family, has a positive-stranded RNA genome, which consists of a single open reading frame (ORF) and nontranslated regions (NTRs) at the 5' and 3' ends. The 5'NTR was found to contain an internal ribosomal entry site (IRES), which is required for the tra...

journal_title：Biochemical and biophysical research communications

authors： Kim YK,Kim CS,Lee SH,Jang SK

更新日期：2002-01-11 00:00:00

abstract：:The c-Jun N-terminal Kinases (JNKs) play important roles in cell responses to stress or growth factor stimulation. The JNK1α1 isoform shares >90% identity with a predominantly neuronal JNK3α1 isoform, but JNK3α1 also includes a distinctive 38 amino acid N-terminal sequence. To address the outstanding question of the p...

journal_title：Biochemical and biophysical research communications

authors： Chen WK,Yeap YY,Bogoyevitch MA

更新日期：2014-10-24 00:00:00

abstract：:In this study, an endogenous factor(s) involved in the suppression of the induction of CYP1A1 was studied. Analyzing the sequences, we found that the sequence of xenobiotic responsive element (XRE) in the upstream region of the human CYP1A1 gene was overlapped with that of the upstream stimulatory factor 1 (USF1)-bind...

journal_title：Biochemical and biophysical research communications

authors： Takahashi Y,Nakayama K,Itoh S,Kamataki T

更新日期：1997-11-17 00:00:00

abstract：:EGF stimulates gene expression through a variety of signal transduction pathways that include the ras-Erk pathway. We have shown previously that EGF receptor activation stimulates gastrin gene expression through a GC-rich element called gERE. This element binds Sp1 family members and raises the possibility that the ra...

journal_title：Biochemical and biophysical research communications

authors： Merchant JL,Du M,Todisco A

更新日期：1999-01-19 00:00:00

abstract：:Amyloid-beta (Abeta) is the core component of senile plaques, which are the pathological markers for Alzheimer's disease and cerebral amyloid angiopathy. DNA methylation/demethylation plays a crucial role in gene regulation and could also be responsible for presentation of senescence. Oxidative stress, which may be in...

journal_title：Biochemical and biophysical research communications

authors： Chen KL,Wang SS,Yang YY,Yuan RY,Chen RM,Hu CJ

更新日期：2009-01-02 00:00:00

abstract：:Small membrane-bound extracellular organelles known as articular cartilage matrix vesicles (ACVs) participate in pathologic mineralization in osteoarthritic articular cartilage. ACVs are also present in normal cartilage, although they have no known functions other than mineralization. Recently, RNA was identified in e...

journal_title：Biochemical and biophysical research communications

authors： Mitton E,Gohr CM,McNally MT,Rosenthal AK

更新日期：2009-10-23 00:00:00

abstract：:Sequence was obtained from a cDNA clone, designated ERD1, isolated from a cDNA library of 1-hour-dehydrated plants of Arabidopsis thaliana L. The clone (3150 bp) contains an open reading frame of 946 amino acid residues with greater than 34% sequence identity to the regulatory subunit of the Clp ATP-dependent protease...

journal_title：Biochemical and biophysical research communications

authors： Kiyosue T,Yamaguchi-Shinozaki K,Shinozaki K

更新日期：1993-11-15 00:00:00

abstract：:The major bovine seminal plasma protein, PDC-109 exhibits chaperone-like activity (CLA) against a variety of target proteins. The present studies show that the homologous protein from equine seminal plasma, HSP-1/2 also exhibits CLA and inhibits the thermal aggregation of target proteins such as lactate dehydrogenase,...

journal_title：Biochemical and biophysical research communications

authors： Sankhala RS,Kumar CS,Singh BP,Arangasamy A,Swamy MJ

更新日期：2012-10-12 00:00:00

abstract：:In a simple salts medium, monolayers of IEC-6 intestinal cells achieved concentrations of unmetabolized formycin B (an analog of inosine) about 6-fold higher than in the medium. Rates of formycin B influx were a saturable function of Na+ concentrations in the medium. Although IEC-6 cells possess sites with high affini...

journal_title：Biochemical and biophysical research communications

authors： Jakobs ES,Paterson AR

更新日期：1986-11-14 00:00:00

abstract：:DJ-1 is a multi-functional protein that plays roles in transcriptional regulation and anti-oxidative stress, and loss of its function is thought to result in onset of Parkinson's disease. We have previously reported that L166P, a mutant DJ-1 found in Parkinson's disease patients, had no activity to prevent hydrogen pe...

journal_title：Biochemical and biophysical research communications

authors： Takahashi-Niki K,Niki T,Taira T,Iguchi-Ariga SM,Ariga H

更新日期：2004-07-23 00:00:00

abstract：:Protein kinase C (PKC) is essential in intracellular signal transduction for various cell functions including natural killer (NK) cell activity. This enzyme is hydrolysed by calpain, which is Ca2+-dependent thiol proteinase. We showed here that in NK activity-deficient beige (bg/bg) mouse, the model of Chediak-Higashi...

journal_title：Biochemical and biophysical research communications

authors： Ito M,Sato A,Tanabe F,Ishida E,Takami Y,Shigeta S

更新日期：1989-04-28 00:00:00

abstract：:TAp63 belongs to the p53-tumour suppressor family and is capable of transactivating a set of target genes to induce cell cycle arrest and apoptosis. We showed that treatment of cancer cells with chemo-therapeutic drugs or the histone deacetylase (HDAC) inhibitor Trichostatin A (TSA) results in induction of TAp63 expre...

journal_title：Biochemical and biophysical research communications

authors： Sayan BS,Yang AL,Conforti F,Bernardini S,Tucci P,Vasa-Nicotera M,Knight RA,Melino G

更新日期：2010-01-22 00:00:00

abstract：:Traumatic spinal cord injury (SCI) is a major cause of death and lifelong disability in the world. However, the pathological process of SCI has not been fully understood. F-box/WD repeat-containing protein 5 (FBXW5), a subunit of the SCF-type E3 ubiquitin ligase complex, plays an essential role in regulating various p...

journal_title：Biochemical and biophysical research communications

authors： Zhao P,Chao W,Li W

更新日期：2019-06-25 00:00:00

abstract：:The expression of the transcription factor Sp1 and EGF receptor (EGFR) was examined on human gastric carcinoma cell lines and gastric carcinoma tissues as well as corresponding normal mucosa in order to clarify the mechanism of overexpression of EGFR gene without gene amplification. All 7 carcinoma cell lines expresse...

journal_title：Biochemical and biophysical research communications

authors： Kitadai Y,Yasui W,Yokozaki H,Kuniyasu H,Haruma K,Kajiyama G,Tahara E

更新日期：1992-12-30 00:00:00

abstract：:A significant percentage of the methyltransferasome in Saccharomyces cerevisiae and higher eukaryotes is devoted to methylation of the translational machinery. Methylation of the RNA components of the translational machinery has been studied extensively and is important for structure stability, ribosome biogenesis, an...

journal_title：Biochemical and biophysical research communications

authors： Al-Hadid Q,White J,Clarke S

更新日期：2016-02-12 00:00:00

abstract：:Amantadine and oseltamivir are used to treat influenza A virus infections; however, resistance to these drugs has been widely reported throughout the world. In this study, the frequency and genetic characteristics of the drug-resistant influenza A viruses that circulated in Thailand from 2006 to 2008 were investigated...

journal_title：Biochemical and biophysical research communications

authors： Bai GR,Chittaganpitch M,Kanai Y,Li YG,Auwanit W,Ikuta K,Sawanpanyalert P

更新日期：2009-12-18 00:00:00

abstract：:The presence of a significantly increased content of free-cystine in skin fibroblasts from both homozygotes and heterozygotes for cystinosis emphasizes the central role of cystine in this disease, even though the primary defect responsible for cystine accumulation is yet to be determined. The studies described in this...

journal_title：Biochemical and biophysical research communications

authors： Schneider JA,Rosenbloom FM,Bradley KH,Seegmiller JE

更新日期：1967-11-30 00:00:00

abstract：:Male rats were exposed to freshly generated cigarette smoke once daily for 4 to 8 weeks. Inhalation of smoke was verified by elevated level of carboxyhemoglobin. Arachidonate metabolism through lipoxygenase and cyclooxygenase pathways in platelets was determined. Cigarette smoking increased 12-lipoxygenase activity si...

journal_title：Biochemical and biophysical research communications

authors： Chang WC,Fukuda S,Tai HH

更新日期：1983-09-15 00:00:00

abstract：:Nutritional and pharmacological factors are needed to prevent bone loss that occurs with increasing age. The chemical compounds that act on bone metabolism as nutrients in food, however, are poorly understood. The effect of resveratrol, a natural phytoestrogen, on the proliferation and differentiation of osteoblastic ...

journal_title：Biochemical and biophysical research communications

authors： Mizutani K,Ikeda K,Kawai Y,Yamori Y

更新日期：1998-12-30 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and often fatal pulmonary disorder, and its pathology is characterized by parenchymal fibrosis. To investigate the characteristics of fibroblasts in IPF, we obtained eight fibroblast cell lines from lungs with IPF and eight lines from normal lungs. We foun...

journal_title：Biochemical and biophysical research communications

authors： Shoda H,Yokoyama A,Nishino R,Nakashima T,Ishikawa N,Haruta Y,Hattori N,Naka T,Kohno N

更新日期：2007-02-23 00:00:00

abstract：:Sequence analysis of a new lignin peroxidase (LIP) gene, GLG6, from P. chrysosporium showed that it encodes a mature LIP protein with a predicted Mr of 36,454. A 28 aa signal peptide precedes the mature protein. The coding region of GLG6 is interrupted by nine introns ranging in size from 50-57 bp. GLG6 encoded-LIP ha...

journal_title：Biochemical and biophysical research communications

authors： Naidu PS,Zhang YZ,Reddy CA

更新日期：1990-12-31 00:00:00

abstract：:Toxoplasmosis is a worldwide disease caused by Toxoplasma gondii. Activated macrophages control T. gondii growth by nitric oxide (NO) production. However, T. gondii active invasion inhibits NO production, allowing parasite persistence. Here we show that the mechanism used by T. gondii to inhibit NO production persisti...

journal_title：Biochemical and biophysical research communications

authors： Seabra SH,de Souza W,Damatta RA

更新日期：2004-11-12 00:00:00

abstract：:The CD133 antigen, identified as a hematopoietic stem cell marker, appears in various human embryonic epithelia including the neural tube, gut, and kidney. We herein investigated whether CD133(+) cells isolated from human hepatocellular carcinoma cell lines possess cancer stem/progenitor cell-like properties. Among th...

journal_title：Biochemical and biophysical research communications

authors： Suetsugu A,Nagaki M,Aoki H,Motohashi T,Kunisada T,Moriwaki H

更新日期：2006-12-29 00:00:00

abstract：:To identify the source of arachidonic acid utilized for eicosanoid production, rabbit alveolar macrophages were challenged with 1.0 microM 12-O-tetradecanoylphorbol-13-acetate (TPA) or 3.8 microM Ca+2 ionophore A23187 for 3 h. Upon stimulation with TPA, a loss of [3H]arachidonic acid from phosphatidylcholine, phosphat...

journal_title：Biochemical and biophysical research communications

authors： Cochran FR,Connor JR,Roddick VL,Waite BM

更新日期：1985-07-31 00:00:00

abstract：:We initiated the present work as part of an effort to identify and characterize genes from the EST2-HMG14 region from human chromosome 21 potentially responsible for some of the Down syndrome (DS) features. Genomic sample sequencing with cosmid clone A1047 located in the ETS2-HMG14 region of chromosome 21 has led to t...

journal_title：Biochemical and biophysical research communications

authors： Vidal-Taboada JM,Sanz S,Egeo A,Scartezzini P,Oliva R

更新日期：1998-09-29 00:00:00

abstract：:Chromatin spatial organization is essential for transcriptional modulation and stabilization. The pattern of DNA distal interplay form the multiple topological associating domains (TADs), and further assemble the functional compartmentalization with open and expression-active chromatin ("A" compartments) or closed and...

journal_title：Biochemical and biophysical research communications

authors： Gong W,Liu Y,Qu H,Liu A,Sun P,Wang X

更新日期：2019-03-19 00:00:00

abstract：:The efficacy and specificity of a novel synthetic thrombin inhibitor, DuP 714, on thrombin-induced elevation of cytoplasmic calcium, fibrinogen binding and aggregation in human platelets were examined. Thrombin (0.5 U/ml) stimulated an increase in [125I]fibrinogen binding in gel-filtered platelets which was blocked by...

journal_title：Biochemical and biophysical research communications

authors： Chiu AT,Mousa SA,Pease LJ,Roscoe WA,Bozarth JM,Reilly TM,Smith RD,Timmermans PB

更新日期：1991-09-30 00:00:00

abstract：:The ΔpH-dependent/Tat pathway is unique for using only the proton motive force for driving proteins transport across the thylakoid membrane in chloroplasts. 9-aminoacridine fluorescence quenching is widely used to monitor the ΔpH developed across the thylakoid membrane in the light. However, this method suffers from l...

journal_title：Biochemical and biophysical research communications

authors： Yang H,Pu X,Wang L,Liu L,Theg SM

更新日期：2017-04-22 00:00:00

abstract：:Lipoteichoic acid is a major cell wall virulence factor of gram-positive bacteria. LTAs from various bacteria have differential immunostimulatory potentials due to heterogeneity in their structures. Although recent studies have demonstrated that LTA isolated from Lactobacillus plantarum (pLTA) has anti-inflammatory pr...

journal_title：Biochemical and biophysical research communications

authors： Jang KS,Baik JE,Han SH,Chung DK,Kim BG

更新日期：2011-04-22 00:00:00