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Characterization of CD133+ hepatocellular carcinoma cells as cancer stem/progenitor cells.

Abstract：

:The CD133 antigen, identified as a hematopoietic stem cell marker, appears in various human embryonic epithelia including the neural tube, gut, and kidney. We herein investigated whether CD133(+) cells isolated from human hepatocellular carcinoma cell lines possess cancer stem/progenitor cell-like properties. Among the three cell lines studied, the CD133 antigen was found to be expressed only on the surface of Huh-7 cells. CD133(+) cells from Huh-7 performed a higher in vitro proliferative potential and lower mRNA expressions of mature hepatocyte markers, glutamine synthetase and cytochrome P450 3A4, than CD133(-) population of Huh-7 cells. When either CD133(+) or CD133(-) cells were subcutaneously injected into SCID mice, CD133(+) cells formed tumors, whereas CD133(-) cells induced either a very small number of tumors or none at all. Taken together, the identification of CD133(+) cells could thus be a potentially powerful tool to investigate the tumorigenic process in the hepatoma system and to also develop effective therapies targeted against hepatocellular carcinoma.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Suetsugu A,Nagaki M,Aoki H,Motohashi T,Kunisada T,Moriwaki H

doi

10.1016/j.bbrc.2006.10.128

subject

Has Abstract

pub_date

2006-12-29 00:00:00

pages

820-4

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(06)02324-2

journal_volume

351

pub_type

杂志文章

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