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Circadian expression of clock genes in human peripheral leukocytes.

Abstract：

:In mammals, behavioral and physiological processes display 24-h rhythms that are regulated by a circadian system. In the present study, we investigated the possibility that the expression of clock genes in peripheral leukocytes can be used to assess the circadian clock system. We found that Per1 and Per2 exhibit circadian oscillations in mRNA expression in mouse peripheral leukocytes. Furthermore, the rhythms of Per1 and Per2 mRNA expression in peripheral leukocytes are severely blunted in homozygous Cry1/2 double-deficient mice that are known to have an abolished biological clock. We have examined the circadian expression of clock genes in human leukocytes and found that Per1 mRNA exhibits a robust circadian expression while Per2 and Bmal1 mRNA showed weak rhythm. These observations suggest that monitoring Per1 mRNA expression in human leukocytes may be useful for investigating the function of the circadian system in physiological and pathophysiological states.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Fukuya H,Emoto N,Nonaka H,Yagita K,Okamura H,Yokoyama M

doi

10.1016/j.bbrc.2007.01.063

subject

Has Abstract

pub_date

2007-03-23 00:00:00

pages

924-8

issue

4

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(07)00111-8

journal_volume

354

pub_type

杂志文章

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