Plasma lipoproteins mediate platelet adhesion.

Abstract:

:Platelet adhesion to VLDL, LDL, HDL, and to a mixture of purified apolipoproteins was examined. Platelets adhered to all the classes of lipoproteins tested. VLDL and the apolipoprotein mixture promoted the greatest degree of adhesion. Platelet adhesion was inhibited by addition of EDTA, RGD-containing peptides and anti-GPIIb-IIIa, monoclonal antibodies. Platelets from patients with Glanzmann's Thrombasthenia which lack the GPIIb-IIIa receptor adhered to VLDL less than half as well as did normal platelets. These results demonstrate that the major circulating lipoproteins can mediate in vitro platelet adhesion and that this adhesion occurs via platelet integrin receptors. We postulate that lipoprotein mediated platelet adhesion may play an important role in the progression of atherosclerosis.

authors

Kowalska MA,Tuszynski GP,Capuzzi DM

doi

10.1016/s0006-291x(05)80180-9

subject

Has Abstract

pub_date

1990-10-15 00:00:00

pages

113-8

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(05)80180-9

journal_volume

172

pub_type

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