当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Klotho ameliorates diabetic nephropathy by activating Nrf2 signaling pathway in podocytes.

Klotho ameliorates diabetic nephropathy by activating Nrf2 signaling pathway in podocytes.

Abstract：

:Oxidative stress plays a key role in the pathogenesis of diabetic nephropathy (DN). The anti-aging protein Klotho has been demonstrated to have antioxidant capacity. Nuclear factor-erythroid 2-related factor 2 (Nrf2) is a central transcription factor regulating antioxidant responses. The present study aimed to explore the effects of Klotho on DN and the underlying mechanisms related to Nrf2. Low glucose (LG) or high glucose (HG) medium-cultured podocytes and diabetic db/db mice were overexpressed with Klotho via adenoviral transfer to evaluate the effects of Klotho on Nrf2 signaling, oxidative stress, podocyte apoptosis, and renal function and histopathology. Klotho overexpression significantly induced the expression and activation of Nrf2 as well as its downstream targets SOD2 and NQO1 in podocytes. Moreover, Klotho overexpression inhibited HG-induced oxidative stress and apoptosis in podocytes. Co-treatment with Nrf2 inhibitor trigonelline prevented Klotho-induced expression of SOD2 and NQO1, and abolished Klotho-conferred antioxidant and anti-apoptotic effects. In db/db mice, Klotho overexpression also activated Nrf2 signaling, and suppressed diabetes-induced oxidative stress and podocyte apoptosis, which were accompanied by improved renal function and decreased glomerulosclerosis. Our data highlight a novel Nrf2-mediated antioxidant mechanism underlying the protective effects of Klotho in podocytes and indicate the therapeutic potential of targeting Klotho to activate Nrf2 in DN.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Xing L,Guo H,Meng S,Zhu B,Fang J,Huang J,Chen J,Wang Y,Wang L,Yao X,Wang H

doi

10.1016/j.bbrc.2020.11.061

subject

Has Abstract

pub_date

2021-01-01 00:00:00

pages

450-456

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(20)32106-9

journal_volume

534

pub_type

杂志文章

相关文献

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS文献大全
  • Phylogenetic origin and sequence features of MreB from the wall-less swimming bacteria Spiroplasma.

    abstract：:Spiroplasma are wall-less bacteria which belong to the phylum Tenericutes that evolved from Firmicutes including Bacillus subtilis. Spiroplasma swim by a mechanism unrelated to widespread bacterial motilities, such as flagellar motility, and caused by helicity switching with kinks traveling along the helical cell body...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2020.09.060

    authors： Takahashi D,Fujiwara I,Miyata M

    更新日期：2020-12-17 00:00:00

  • Toxoplasma gondii exposes phosphatidylserine inducing a TGF-beta1 autocrine effect orchestrating macrophage evasion.

    abstract：:Toxoplasmosis is a worldwide disease caused by Toxoplasma gondii. Activated macrophages control T. gondii growth by nitric oxide (NO) production. However, T. gondii active invasion inhibits NO production, allowing parasite persistence. Here we show that the mechanism used by T. gondii to inhibit NO production persisti...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.09.114

    authors： Seabra SH,de Souza W,Damatta RA

    更新日期：2004-11-12 00:00:00

  • Oligomerization of the transmembrane domain of IRE1α in SDS micelles.

    abstract：:IRE1α (Inositol-requiring enzyme 1 α), an endoplasmic reticulum (ER)-resident sensor for mammalian unfolded protein response, is a type I transmembrane protein which has a bifunctional enzyme containing kinase and RNase domains. Although the luminal domain and cytosolic domain of IRE1α are thought to play crucial role...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.09.135

    authors： Cho H,Lamarca R,Chan C

    更新日期：2012-11-02 00:00:00

  • The epigenetic effects of amyloid-beta(1-40) on global DNA and neprilysin genes in murine cerebral endothelial cells.

    abstract：:Amyloid-beta (Abeta) is the core component of senile plaques, which are the pathological markers for Alzheimer's disease and cerebral amyloid angiopathy. DNA methylation/demethylation plays a crucial role in gene regulation and could also be responsible for presentation of senescence. Oxidative stress, which may be in...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.10.173

    authors： Chen KL,Wang SS,Yang YY,Yuan RY,Chen RM,Hu CJ

    更新日期：2009-01-02 00:00:00

  • A novel heteroplasmic tRNA(Leu(CUN)) mtDNA point mutation associated with chronic progressive external ophthalmoplegia.

    abstract：:We have sequenced all mitochondrial tRNA genes from a patient with chronic progressive external ophthalmoplegia (CPEO) and mitochondrial myopathy, who had no detectable large mtDNA deletions. Direct sequencing failed to detect previously reported mutations and showed a heteroplasmic mutation at nucleotide 12,276 in th...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.11.170

    authors： Cardaioli E,Da Pozzo P,Radi E,Dotti MT,Federico A

    更新日期：2005-02-18 00:00:00

  • Therapeutic effects of antibiotic drug tigecycline against cervical squamous cell carcinoma by inhibiting Wnt/β-catenin signaling.

    abstract：:Aberrant activation of the Wnt/β-catenin signaling pathway is common in human cervical cancers and has great potential therapeutic value. We show that tigecycline, a FDA-approved antibiotic drug, targets cervical squamous cell carcinoma through inhibiting Wnt/β-catenin signaling pathway. Tigecycline is effective in in...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2015.09.140

    authors： Li H,Jiao S,Li X,Banu H,Hamal S,Wang X

    更新日期：2015-11-06 00:00:00

  • Influence of divalent cations on the cytoskeletal dynamics of K562 cells determined by nano-scale bead tracking.

    abstract：:Cytoskeletal reorganization processes can be analyzed by studying the nanometer-scale spontaneous motion of beads bound to the cytoskeleton. The bead motion is determined by force fluctuations within the cytoskeletal network that originates from myosin motor activity and dynamic restructuring of cytoskeletal filaments...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.03.145

    authors： Alonso JL,Goldmann WH

    更新日期：2012-05-04 00:00:00

  • Biochemical evidence for the long-tail form (A beta 1-42/43) of amyloid beta protein as a seed molecule in cerebral deposits of Alzheimer's disease.

    abstract：:We measured the amounts of total A beta, A beta 1-40 and A beta 1-42/43 in brain tissues using a newly developed ELISA assay and found that the amounts of insoluble A beta 1-42/43 and insoluble A beta 1-40 were linearly related to the amount of A beta deposits or total insoluble A beta at their lower and higher concen...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1994.2740

    authors： Tamaoka A,Kondo T,Odaka A,Sahara N,Sawamura N,Ozawa K,Suzuki N,Shoji S,Mori H

    更新日期：1994-11-30 00:00:00

  • Shadoo binds lipid membranes and undergoes aggregation and fibrillization.

    abstract：:Lipid membrane can enhance prion protein (PrP) pathological fibrillogenesis. A neuronal paralog of PrP, named Shadoo (Sho), is localized to similar membrane environment as PrP and can also convert to amyloid-like fibrilles. To gain insight into the role of Sho in prion diseases, we studied Sho interactions with cellul...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2013.07.104

    authors： Li Q,Chevalier C,Henry C,Richard CA,Moudjou M,Vidic J

    更新日期：2013-08-30 00:00:00

  • Angiogenin is involved in morphological changes and angiogenesis in the ovary.

    abstract：:Angiogenin is a potent angiogenic factor secreted by cultured tumor cells and is found in various normal organs and tissues. The ovary is one of the adult organs in which angiogenesis normally occurs during the female reproductive cycle. In this study, we examined whether angiogenin protein is localized and if angioge...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1999.0359

    authors： Lee HS,Lee IS,Kang TC,Jeong GB,Chang SI

    更新日期：1999-04-02 00:00:00

  • Hes1-deficient mice show precocious differentiation of Paneth cells in the small intestine.

    abstract：:We have previously shown that Hes1 is expressed both in putative epithelial stem cells just above Paneth cells and in the crypt base columnar cells between Paneth cells, while Hes1 is completely absent in Paneth cells. This study was undertaken to clarify the role of Hes1 in Paneth cell differentiation, using Hes1-kno...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.12.174

    authors： Suzuki K,Fukui H,Kayahara T,Sawada M,Seno H,Hiai H,Kageyama R,Okano H,Chiba T

    更新日期：2005-03-04 00:00:00

  • Essential roles of integrin-mediated signaling for the enhancement of malignant properties of melanomas based on the expression of GD3.

    abstract：:We reported that ganglioside GD3 enhances cell proliferation and invasion of melanomas causing stronger tyrosine-phosphorylation of p130Cas and paxillin after stimulation with fetal calf serum. Besides signals via growth factor/receptor, adhesion signals via integrin might be also enhanced by GD3. Here, roles of integ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2008.05.149

    authors： Ohkawa Y,Miyazaki S,Miyata M,Hamamura K,Furukawa K,Furukawa K

    更新日期：2008-08-15 00:00:00

  • The linker region of Smad2 mediates TGF-beta-dependent ERK2-induced collagen synthesis.

    abstract：:Transforming growth factor (TGF)-beta1 can cause fibrosis diseases by enhancing production of collagen. However, the intracellular signaling mechanism for TGF-beta1 stimulation of this process has not been fully elucidated. The present study focused on this mechanism and the cross-talk between the MAPK and Smad pathwa...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2009.05.084

    authors： Li F,Zeng B,Chai Y,Cai P,Fan C,Cheng T

    更新日期：2009-08-21 00:00:00

  • Molecular characterization of two G protein-coupled receptor splice variants as FLP2 receptors in Caenorhabditis elegans.

    abstract：:Two alternatively spliced Caenorhabditis elegans G protein-coupled receptors, T19F4.1a and T19F4.1b, were cloned and functionally characterized. The T19F4.1b receptor protein is 30 amino acids longer than T19F4.1a, and the difference in amino acid constitution is exclusively conferred to the intracellular C-terminal r...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2005.03.071

    authors： Mertens I,Meeusen T,Janssen T,Nachman R,Schoofs L

    更新日期：2005-05-13 00:00:00

  • Promoter methylation regulates cadherin switching in squamous cell carcinoma.

    abstract：:Cadherins are cell adhesion molecules that modulate the epithelial phenotype and regulate tumor invasion. To identify the role of promoter methylation in regulating E-cadherin expression and in the "switching" of cadherins in oral squamous cell carcinoma (SCC), we studied 14 cell lines for cadherin expression. Immunob...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.01.143

    authors： Chen Q,Lipkina G,Song Q,Kramer RH

    更新日期：2004-03-19 00:00:00

  • Methylene blue induces an analgesic effect by significantly decreasing neural firing rates and improves pain behaviors in rats.

    abstract：:Methylene blue (MB) is a blue cationic thiazine dye and currently used in different medical settings. Notably, there have been several attempts to introduce MB for attenuating pain in the last decade. Some clinical studies reported remarkable results, which, however, have been much debated. In addition, accumulating e...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2021.01.008

    authors： Lee SW,Moon SW,Park JS,Suh HR,Han HC

    更新日期：2021-01-16 00:00:00

  • The high affinity murine laminin receptor is a member of a multicopy gene family.

    abstract：:The high affinity laminin receptor is differentially expressed in metastasis. We now report that there are multiple copies (6 +/- 1) of the laminin receptor gene in the murine genome of normal diploid cells as well as in cell lines derived from cancer cells. We have analyzed three distinct cDNA clones isolated from an...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(05)81203-3

    authors： Fernández MT,Castronovo V,Rao CN,Sobel ME

    更新日期：1991-02-28 00:00:00

  • Effects of replacement of tryptophan-140 by phenylalanine or glycine on the function of Escherichia coli aspartate aminotransferase.

    abstract：:Trp140 of E. coli aspartate aminotransferase has been converted to Phe or Gly by site-directed mutagenesis. As compared to the wild-type enzyme, either of the mutant enzymes showed 10- to 100-fold increase in Km's for natural dicarboxylic substrates, but did not show appreciable changes in Km's for aromatic substrates...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/0006-291x(90)92037-z

    authors： Hayashi H,Inoue Y,Kuramitsu S,Morino Y,Kagamiyama H

    更新日期：1990-03-16 00:00:00

  • NLRP3/ASC/Caspase-1 axis and serine protease activity are involved in neutrophil IL-1β processing during Streptococcus pneumoniae infection.

    abstract：:Streptococcus pneumoniae is a pathogenic bacterium that can cause severe invasive diseases, such as pneumonia, otitis media and meningitis. The pro-inflammatory cytokine, IL-1β, has been reported to play important role in host defense against S. pneumoniae. The mechanism of IL-1β maturation and secretion in macrophage...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2019.04.004

    authors： Zhang T,Du H,Feng S,Wu R,Chen T,Jiang J,Peng Y,Ye C,Fang R

    更新日期：2019-06-04 00:00:00

  • Control of PTH secretion is mediated through calcium channels and is blocked by pertussis toxin treatment of parathyroid cells.

    abstract：:Parathyroid hormone secretion is negatively regulated by calcium. We utilized calcium channel agents: +202-791, a calcium channel agonist and -202-791, a calcium channel antagonist, to evaluate the role of calcium channels in PTH secretion. +202-791 inhibited PTH release from bovine parathyroid cells and the antagonis...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(86)80589-7

    authors： Fitzpatrick LA,Brandi ML,Aurbach GD

    更新日期：1986-07-31 00:00:00

  • Over-expression of Mxi1 represses renal epithelial tubulogenesis through the reduction of matrix metalloproteinase 9.

    abstract：:Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary renal disease. ADPKD is characterized by cyst development that leads to abnormal kidney structure. Renal tubules are a fundamental unit of architecture, so controls of tubular growth and formation are important for proper kidney functio...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2012.02.002

    authors： Song SA,Yoo KH,Ko JY,Kim BH,Yook YJ,Park JH

    更新日期：2012-03-16 00:00:00

  • Human monocytes possess a serine protease activity capable of degrading HIV-1 reverse transcriptase in vitro.

    abstract：:Human immunodeficiency virus type-1 (HIV-1) reverse transcriptase (RT) plays a central role in the virus replication cycle. We found that HIV-1 RT was rapidly degraded when incubated with cell extracts obtained from human peripheral blood cells. The proteolytic activity responsible for the in vitro degradation of RT w...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.2001.5252

    authors： Château MT,Robert-Hebmann V,Devaux C,Lazaro JB,Canard B,Coux O

    更新日期：2001-07-27 00:00:00

  • Structural and functional similarity between fish antifreeze proteins and calcium-dependent lectins.

    abstract：:A cDNA for a type II antifreeze protein was isolated from liver of smelt (Osmerus mordax). The predicted protein sequence is homologous to that from sea raven (Hemitripterus americanus) and both show homology to a family of calcium-dependent lectins. Smelt and sea raven belong to taxonomic orders believed to have dive...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(05)90005-3

    authors： Ewart KV,Rubinsky B,Fletcher GL

    更新日期：1992-05-29 00:00:00

  • Adipocyte-derived microvesicles contain RNA that is transported into macrophages and might be secreted into blood circulation.

    abstract：:We have recently found that 3T3-L1 adipocytes secrete microvesicles, known as adipocyte-derived microvesicles (ADMs), with angiogenic activity. In this study, we found that ADMs contain RNA without typical 28S and 18S ribosomal RNA inside the vesicles. Microarray analysis revealed that ADMs contain approximately 7000 ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2010.07.008

    authors： Ogawa R,Tanaka C,Sato M,Nagasaki H,Sugimura K,Okumura K,Nakagawa Y,Aoki N

    更新日期：2010-08-06 00:00:00

  • A novel, anchorless streptococcal surface protein that binds to human immunoglobulins.

    abstract：:We have characterized a novel surface protein from urea extract of whole cells of group A Streptococcus pyogenes (GAS). A major protein band (35kD) was found to hybridize with human IgG by Western blotting. A search of the N-terminal amino acid sequence of this protein by using the GAS genome sequence database reveale...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/s0006-291x(02)02078-8

    authors： Kawabata S,Tamura Y,Murakami J,Terao Y,Nakagawa I,Hamada S

    更新日期：2002-09-06 00:00:00

  • Dynamics of catalysis revealed from the crystal structures of mutants of diaminopimelate epimerase.

    abstract：:Diaminopimelate (DAP) epimerase catalyzes the stereoinversion of ll-DAP to meso-DAP, a precursor of l-lysine and an essential component of the bacterial peptidoglycan. This function is vital to bacteria and the enzyme therefore represents an attractive target for the design of novel anti-bacterials. DAP epimerase belo...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2007.09.012

    authors： Pillai B,Cherney M,Diaper CM,Sutherland A,Blanchard JS,Vederas JC,James MN

    更新日期：2007-11-23 00:00:00

  • Hydrogen peroxide production is affected by oxygen levels in mammalian cell culture.

    abstract：:Although oxygen levels in the extracellular space of most mammalian tissues are just a few percent, under standard cell culture conditions they are not regulated and are often substantially higher. Some cellular sources of reactive oxygen species, like NADPH oxidase 4, are sensitive to oxygen levels in the range betwe...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2017.09.037

    authors： Maddalena LA,Selim SM,Fonseca J,Messner H,McGowan S,Stuart JA

    更新日期：2017-11-04 00:00:00

  • Lens-specific expression of a chicken beta A3/A1-crystallin promoter fragment in transgenic mice.

    abstract：:Beta A3/A1-crystallin is one of the major refractive proteins of the chicken eye lens. Previously we showed that a fragment from -382 to +22 bp of the beta A3/A1-crystallin gene functions as a promoter in transfected lens cells. Here we show by use of the bacterial chloramphenicol acetyltransferase reporter gene that ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1006/bbrc.1996.0635

    authors： McDermott JB,Cvekl A,Piatigorsky J

    更新日期：1996-04-25 00:00:00

  • Corticotropin-releasing hormone activates protein kinase C in an isoenzyme-specific manner.

    abstract：:Protein kinase C (PKC) has recently emerged as mediator of corticotropin-releasing hormone (CRH) effects. Aim of the present study was to study the effects of CRH on each PKC isoenzyme. As a model we have used the PC12 rat pheochromocytoma cell line, expressing the CRH type 1 receptor (CRHR1). Our data were as follows...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章

    doi：10.1016/j.bbrc.2004.12.078

    authors： Dermitzaki E,Tsatsanis C,Charalampopoulos I,Androulidaki A,Alexaki VI,Castanas E,Gravanis A,Margioris AN

    更新日期：2005-02-18 00:00:00

  • Voltage-dependent anion channel in mammalian spermatozoa.

    abstract：:Voltage-dependent anion channel (VDAC) is a multi-functional channel protein in the mitochondrial outer membrane of all eukaryotes. It is involved in extensive physiological and pathophysiological processes. However there is only scant information about VDAC in mammalian reproduction, fertility and development in the ...

    journal_title：Biochemical and biophysical research communications

    pub_type： 杂志文章,评审

    doi：10.1016/j.bbrc.2010.06.025

    authors： Liu B,Zhang W,Wang Z

    更新日期：2010-07-09 00:00:00