Abstract:
:Parathyroid hormone secretion is negatively regulated by calcium. We utilized calcium channel agents: +202-791, a calcium channel agonist and -202-791, a calcium channel antagonist, to evaluate the role of calcium channels in PTH secretion. +202-791 inhibited PTH release from bovine parathyroid cells and the antagonist stimulated release. Incubation with pertussis toxin which ADP-ribosylates and inactivates a guanine nucleotide regulatory protein (G-protein) releases the inhibition by the calcium channel agonist. These findings indicate that a G-protein is interposed between the calcium channel and a putative intracellular site controlling PTH secretion.
journal_name
Biochem Biophys Res Communjournal_title
Biochemical and biophysical research communicationsauthors
Fitzpatrick LA,Brandi ML,Aurbach GDdoi
10.1016/s0006-291x(86)80589-7subject
Has Abstractpub_date
1986-07-31 00:00:00pages
960-5issue
2eissn
0006-291Xissn
1090-2104pii
S0006-291X(86)80589-7journal_volume
138pub_type
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journal_title:Biochemical and biophysical research communications
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