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Erythrocyte membrane nanoparticles improve the intestinal absorption of paclitaxel.

Abstract：

:Paclitaxel (PTX) is a cytotoxic chemotherapy drug with encouraging activity in human malignancies. However, free PTX has a very low oral bioavailability due to its low aqueous solubility and the gastrointestinal drug barrier. In order to overcome this obstacle, we have designed erythrocyte membrane nanoparticles (EMNP) using sonication method. The permeability of PTX by EMNP was 3.5-fold (Papp = 0.425 nm/s) and 16.2-fold (Papp = 394.1 nm/s) higher than free PTX in MDCK-MDR1 cell monolayers and intestinal mucosal tissue, respectively. The in vivo pharmacokinetics indicated that the AUC0-t (μg/mL·h) and Cmax (μg/mL) of EMNP were 14.2-fold and 6.0-fold higher than that of free PTX, respectively. In summary, the EMNP appears to be a promising nanoformulation to enhance the oral bioavailability of insoluble and poorly permeable drugs.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Jiang X,Wang K,Zhou Z,Zhang Y,Sha H,Xu Q,Wu J,Wang J,Wu J,Hu Y,Liu B

doi

10.1016/j.bbrc.2017.05.042

subject

Has Abstract

pub_date

2017-06-24 00:00:00

pages

322-328

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(17)30901-4

journal_volume

488

pub_type

杂志文章

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