Voltage-dependent anion channel in mammalian spermatozoa.

abstract：:Modification of microtubule (MT) dynamics is important for diverse aspects of cellular function including differentiation, cargo trafficking, migration, and adhesion. MTs also play a crucial role in the progression of neuronal development. The MT deacetylase Sirtuin 2 (Sirt2) and histone deacetylase 6 (HDAC6) regulate...

journal_title：Biochemical and biophysical research communications

authors： Jeong SG,Cho GW

更新日期：2017-01-01 00:00:00

abstract：:Although mTOR (mammalian target of rapamycin) activation is frequently observed in acute myeloid leukemia (AML) patients, the precise function and the downstream targets of mTOR are poorly understood. Here we revealed that PFKFB3, but not PFKFB1, PFKFB2 nor PFKFB4 was a novel downstream substrate of mTOR signaling pat...

journal_title：Biochemical and biophysical research communications

authors： Feng Y,Wu L

更新日期：2017-02-05 00:00:00

abstract：:A bank of pTV32 (Tn 917 lacZ) - generated Bacillus subtilis mutants were examined on milk agar for the ability to produce proteases at 48 degrees C. A single mutant, BUL786, was isolated, which could hydrolyze casein after overnight incubation at 48 degrees C. This mutant secreted protease 10 fold more at 48 degrees C...

journal_title：Biochemical and biophysical research communications

authors： Qoronfleh MW,Streips UN

更新日期：1986-07-31 00:00:00

abstract：:Rbx1 and Rbx2 are essential components of Cullin-RING E3 Ligases. Vif is generally believed to preferentially recruit the Cul5-Rbx2 module to induce proteasomal degradation of antiretroviral enzyme APOBEC3G, although some investigators have found that the Cul5-Rbx1 module is recruited. Here, to investigate the functio...

journal_title：Biochemical and biophysical research communications

authors： Wang X,Wang X,Wang W,Zhang J,Wang J,Wang C,Lv M,Zuo T,Liu D,Zhang H,Wu J,Yu B,Kong W,Wu H,Yu X

更新日期：2015-06-12 00:00:00

abstract：:Cultured human lymphocytes and fibroblasts accumulate methotrexate during 24 hours and synthesize methotrexate polyglutamates up to the hexaglutamate, with the triglutamate predominating. In the interval after incubation with methotrexate, drug is lost, metabolites are converted to longer chain-lengths, and methotrexa...

journal_title：Biochemical and biophysical research communications

authors： Whitehead VM,Kalman TI,Vuchich MJ

更新日期：1987-04-14 00:00:00

abstract：:Alternative splicing is a major mechanism regulating pattern of gene expression through the production of multiple mRNAs from a single gene transcript. Any misregulation can cause various human diseases and also have severe effects on embryogenesis. SRSF1 is one of the critical factors regulating alternative splicing ...

journal_title：Biochemical and biophysical research communications

authors： Lee SH,Lee HK,Kim C,Kim YK,Ismail T,Jeong Y,Park K,Park JW,Kwon OS,Kang BS,Lee DS,Park MJ,Park DS,Lee HS

更新日期：2016-09-02 00:00:00

abstract：:Mutations in the preproinsulin protein that affect processing of preproinsulin to proinsulin or lead to misfolding of proinsulin are associated with diabetes. We examined the subcellular localization and secretion of 13 neonatal diabetes-associated human proinsulin proteins (A24D, G32R, G32S, L35P, C43G, G47V, F48C, G...

journal_title：Biochemical and biophysical research communications

authors： Park SY,Ye H,Steiner DF,Bell GI

更新日期：2010-01-15 00:00:00

abstract：:Biochemical studies revealed that the novel rice plant-specific kinesin K16 has several unique enzymatic characteristics as compared to conventional kinesins. The ADP-free form of K16 is very stable, whereas the ADP-free form of conventional kinesins is labile. In the present study, the crystal structure of the novel ...

journal_title：Biochemical and biophysical research communications

authors： Tanaka K,Umeki N,Mitsui T,Fujimoto Z,Maruta S

更新日期：2010-10-15 00:00:00

abstract：:Infections with Pseudomonas aeruginosa (P. aeruginosa) are critical in ventilated and poly-traumatized patients. Most important, these bacteria cause frequent and chronic pulmonary infections in patients with cystic fibrosis. Therefore, identification of molecular mechanisms that mediate the infection of mammalian cel...

journal_title：Biochemical and biophysical research communications

authors： Kirschnek S,Adams C,Gulbins E

更新日期：2005-02-18 00:00:00

abstract：:Prostate androgen regulated (PAR) is a 1038bp novel gene located on chromosome 1 in epidermal differentiation complex. The gene is ubiquitously expressed in normal tissues and is overexpressed in most of their malignant counterparts. PAR cellular function is unknown. Here we report the effect of increased PAR expressi...

journal_title：Biochemical and biophysical research communications

authors： Platica M,Ivan E,Ionescu A,Holland JF,Mora G,Tindall DJ,Mandeli J,Unger PD,Platica O

更新日期：2004-02-13 00:00:00

abstract：:The nucleotide sequence of our cloned HBV DNA (subtype adw) has been determined. When the 165-nucleotide sequence of the pre-S2 region was compared with 7 other published sequences (subtypes adw, adr, ayw, and adyw), we found 38 nucleotide substitutions among different subtypes and 4 (adr) or 6 (adw and ayw) substitut...

journal_title：Biochemical and biophysical research communications

authors： Lo SJ,Chen ML,Chien ML,Lee YH

更新日期：1986-03-13 00:00:00

abstract：:The aminoglycoside antibiotic (AGA) neomycin is a known agonist of the extracellular calcium-sensing receptor (CaR). To test whether other AGA drugs stimulate the CaR, we studied the relative effects of four AGAs on intracellular Ca(2+) concentration ([Ca(2+)](i)) using CaR-transfected human embryonic kidney (HEK)-293...

journal_title：Biochemical and biophysical research communications

authors： McLarnon S,Holden D,Ward D,Jones M,Elliott A,Riccardi D

更新日期：2002-09-13 00:00:00

abstract：:Epidemiologic studies suggest that low to moderate consumption of red wine is inversely associated with the risk of coronary heart disease; the protection is in part attributed to grape-derived polyphenols, notably trans-resveratrol, present in red wine. It is not clear whether the cardioprotective effects of resverat...

journal_title：Biochemical and biophysical research communications

authors： Wang Z,Chen Y,Labinskyy N,Hsieh TC,Ungvari Z,Wu JM

更新日期：2006-07-21 00:00:00

abstract：:Intricate cross-talks exist among multiple post-translational modifications that play critical roles in various cellular events, such as the control of gene expression and regulation of protein function. Here, the cross-talk between O-GlcNAcylation and ubiquitination was investigated in HEK293T cells. By PCR array, 84...

journal_title：Biochemical and biophysical research communications

authors： Feng Z,Hui Y,Ling L,Xiaoyan L,Yuqiu W,Peng W,Lianwen Z

更新日期：2013-08-23 00:00:00

abstract：:Receptor activator of NF-κB (RANK) and RANK ligand (RANKL) are known to play an important role in the development and progression of breast cancer. However, the mechanisms by which stimuli regulate the expression of RANK and RANKL in breast cancer cells are largely unknown. In this study, we show that hypoxia, a commo...

journal_title：Biochemical and biophysical research communications

authors： Tang ZN,Zhang F,Tang P,Qi XW,Jiang J

更新日期：2011-05-13 00:00:00

abstract：PURPOSE:To investigate the expression profiles of IL-6 and STAT3 in Wilms' tumor (WT) and their relationship with disease progression. METHODS:Immunohistochemistry was used to examine IL-6 and STAT3 expression in 58 primary tumors and 18 invasive/metastatic ones. RESULTS:Positive expression rate of IL-6/STAT3 was 39....

journal_title：Biochemical and biophysical research communications

authors： Zhang LJ,Liu W,Gao YM,Qin YJ,Wu RD

更新日期：2013-06-07 00:00:00

abstract：:To search for the signaling critical for the production of tissue inhibitor of metalloproteinase-2 (TIMP-2), we investigated the role of SHP-2 in TIMP-2 production with Concanavalin A (Con A)-treated cells. In wild-type fibroblasts, Con A-treatment dramatically activated TIMP-2 production. In contrast, production of T...

journal_title：Biochemical and biophysical research communications

authors： Biswas MH,Hasegawa HH,Rahman MA,Huang P,Mon NN,Ruhul Amin AR,Senga T,Kannagi R,Hamaguchi M

更新日期：2006-09-29 00:00:00

abstract：:Inflammatory bowel diseases, including ulcerative colitis and Crohn's disease, are persistent disorders that lead to development of colitis-associated cancer (CAC). Facilitated resolution of colitis has been addressed as a novel therapeutic strategy to control development of CAC. Resolvin D1 (RvD1) is an endogenous li...

journal_title：Biochemical and biophysical research communications

authors： Zhong X,Lee HN,Surh YJ

更新日期：2018-02-05 00:00:00

abstract：:In cells, there exists a delicate balance between accumulation of charged metal cations and abundant anionic complexes such as phosphate. When phosphate metabolism is disrupted, cell-wide spread disturbances in metal homeostasis may ensue. The best example is a yeast pho80 mutant that hyperaccumulates phosphate and as...

journal_title：Biochemical and biophysical research communications

authors： Rosenfeld L,Culotta VC

更新日期：2012-02-10 00:00:00

abstract：:Oxidative stress is involved in a multitude of pathological conditions. In the present study, cell cycle arrest was demonstrated in monolayer cultures of Chinese hamster ovary cells subjected to low-level oxidative stress induced by the addition of hydrogen peroxide. Fluorescence-activated cell sorting analysis charac...

journal_title：Biochemical and biophysical research communications

authors： Clopton DA,Saltman P

更新日期：1995-05-05 00:00:00

abstract：:Human milk Lewis-type (alpha 1,3/4) fucosyltransferase (FT) was separated from the plasma-type by chromatography on bovine IgG glycopep-Sepharose using lactose as the selective eluent and further purified on a column of Sephacryl S-100 HR. The alpha 1,3-FT activity towards 2'-fucosyllactose was found to be associated ...

journal_title：Biochemical and biophysical research communications

authors： Chandrasekaran EV,Rhodes JM,Jain RK,Matta KL

更新日期：1994-01-14 00:00:00

abstract：:In isolated rat pancreatic acini, protein expression of RhoA and Rho-associated kinase, ROCK-II, and the formation of immunocomplex of RhoA with ROCK-II were enhanced by CCK-8, carbachol, and the phorbol ester TPA. The ROCK-specific inhibitor, Y-27632, did not alter basal amylase secretion, whereas it potentiated CCK-...

journal_title：Biochemical and biophysical research communications

authors： Kusama K,Nozu F,Awai T,Tanaka S,Honma I,Tsunoda Y,Mitamura K

更新日期：2003-05-30 00:00:00

abstract：:The present study was performed to determine if interleukin-1 (IL-1) acts as a chemical messenger in the central nervous system (CNS) regulation of gastric secretion and ulcer formation, using male Wistar rats. The central injection of IL-1 dose-dependently inhibited gastric acid secretion in pylorus-ligated rats at 1...

journal_title：Biochemical and biophysical research communications

authors： Uehara A,Okumura T,Kitamori S,Takasugi Y,Namiki M

更新日期：1990-12-14 00:00:00

abstract：:A small fraction of tumor cells are thought to possess the potential for both multiple-lineage differentiation and self-renewal, which underlies the cancer stem cell hypothesis. However, the differentiation mechanisms of these cells have not been elucidated due to a lack of appropriate culture methods. Here, we establ...

journal_title：Biochemical and biophysical research communications

authors： Kawamata M,Katsuda T,Yamada Y,Ochiya T

更新日期：2017-01-22 00:00:00

abstract：:Prostaglandin E(2) (PGE(2)) has been shown to negatively regulate adipogenesis. To explore to what extent PGE(2) inhibits the differentiation of cells to adipocytes and to examine whether its effect could be due to EP4 receptor signaling, we used microarrays to analyze the gene expression profiles of 3T3-L1 cells expo...

journal_title：Biochemical and biophysical research communications

authors： Sugimoto Y,Tsuboi H,Okuno Y,Tamba S,Tsuchiya S,Tsujimoto G,Ichikawa A

更新日期：2004-09-24 00:00:00

abstract：:miR-4458, a new tumor-suppressor, was reported to down-regulated in human hepatocellular carcinoma. The expression status, roles and inhibitory mechanisms of miR-4458 in other tumors still need to be clarified. The aim of this study is to investigate the effects of miR-4458 and to elucidate the potential mechanism in ...

journal_title：Biochemical and biophysical research communications

authors： Qin Y,Cheng C,Lu H,Wang Y

更新日期：2016-01-01 00:00:00

abstract：:We present here the biosynthesis of AgNps from the aqueous extract of H. thebaica fruit, and monitored through UV-Vis spectrophotometer. The functional group were characterized through ATR-FTIR spectroscopy, the particle size, morphologies and elemental composition of the nanoparticles were investigated by using TEM, ...

journal_title：Biochemical and biophysical research communications

authors： Bello BA,Khan SA,Khan JA,Syed FQ,Mirza MB,Shah L,Khan SB

更新日期：2017-08-26 00:00:00

abstract：:ELOVL3 is involved in elongating saturated and monounsaturated fatty acids, and is a critical enzyme for lipid accumulation in brown adipocytes during the early phase of tissue recruitment. In addition, ELOVL3 is related to increased fatty acid oxidation in brown adipocytes. However, the potential functions of ELOVL3 ...

journal_title：Biochemical and biophysical research communications

authors： Liu D,Xu JH,Tong HL,Li SF,Yan YQ

更新日期：2017-12-02 00:00:00

abstract：:The expression of mRNA for three isozymes of cytochrome P450, CYP1A1, 1A2 and 3A3, was examined in biopsied samples of colon and rectum from five healthy subjects. Using RT-PCR, it was possible to detect the three CYP mRNA species at both sites in all samples examined. The expression of each CYP mRNA was site-specific...

journal_title：Biochemical and biophysical research communications

authors： Mercurio MG,Shiff SJ,Galbraith RA,Sassa S

更新日期：1995-05-16 00:00:00

abstract：:The findings from several studies have suggested that circulating miRNAs are imbalanced with the genesis of gastric cancer (GC). Both normal and cancer cells can generate and secrete exosomes, which are nanosized membrane vesicles that can transport microRNAs and proteins. Emerging evidence indicates that the exosomes...

journal_title：Biochemical and biophysical research communications

authors： Wang N,Wang L,Yang Y,Gong L,Xiao B,Liu X

更新日期：2017-11-25 00:00:00