An aortic spontaneously active phosphatase dephosphorylates myosin and inhibits actin-myosin interaction.

abstract：:Breast cancer anti-estrogen resistance 3 (BCAR3) is an SH2-containing signal transducer and is implicated in tumorigenesis of breast cancer cells. In this study, we found that BCAR3 mediates the induction of ERK activation and DNA synthesis by insulin, but not by IGF-1. Specifically, the SH2 domain of BCAR3 is involve...

journal_title：Biochemical and biophysical research communications

authors： Oh MJ,Yi SJ,Kim HS,Kim JH,Jeong YH,van Agthoven T,Jhun BH

更新日期：2013-11-29 00:00:00

abstract：:The net content of inositol 1,4,5-trisphosphate [Ins(1,4,5)P3] was measured in bradykinin (BK)-stimulated NIH3T3 fibroblasts and neuroblastoma-glioma hybrid cells (NG108-15). BK-mediated production of Ins(1,4,5)P3 was not affected by replacing the medium with Ca2+-free medium, but addition of EGTA (1mM) to Ca2+-free m...

journal_title：Biochemical and biophysical research communications

authors： Fu T,Okano Y,Nozawa Y

更新日期：1988-12-30 00:00:00

abstract：:The molecular forms of endothelin (ET) related peptides were investigated in porcine brain by using high performance liquid chromatography coupled with three specific radioimmunoassays. ET-1 and its oxidized form were isolated and sequenced as in the case of porcine spinal cord. A very small amount of big ET-1 (1-39) ...

journal_title：Biochemical and biophysical research communications

authors： Shinmi O,Kimura S,Sawamura T,Sugita Y,Yoshizawa T,Uchiyama Y,Yanagisawa M,Goto K,Masaki T,Kanazawa I

更新日期：1989-10-16 00:00:00

abstract：:Osteoblasts mediate much of the hormonal responsiveness of osteoclasts. We and others have found that one mechanism through which this regulation is effected is by release of osteoclast resorption-stimulating activity (ORSA) into culture supernatants. However, although hormonal responsiveness is regularly observed in ...

journal_title：Biochemical and biophysical research communications

authors： Fuller K,Gallagher AC,Chambers TJ

更新日期：1991-11-27 00:00:00

abstract：:Microcalorimetric titrations have been used to study the binding of Ca2+ to cardiac troponin C. Measurements were made both in the presence and in the absence of Mg2+, and at temperatures of 5 degrees, 15 degrees and 25 degrees C. Changes in enthalpy, entropy and heat capacity of troponin C associated with Ca binding ...

journal_title：Biochemical and biophysical research communications

authors： Kometani K,Yamada K

更新日期：1983-07-18 00:00:00

abstract：:Rare cold-inducible 2 (RCI2) proteins are small hydrophobic proteins that are known to be localized in cellular membranes. The function of RCI2 proteins has been reported to be associated with low-temperature, salt, and drought stress tolerances as a membrane potential regulator; however, the specific functions are st...

journal_title：Biochemical and biophysical research communications

authors： Kim HS,Park W,Lim HG,Eom S,Lee JH,Carlson JE,Ahn SJ

更新日期：2019-05-21 00:00:00

abstract：:In the present study, we investigated if Cl(-) regulates the proliferation of the MC3T3-E1 osteoblastic cells. The proliferation of MC3T3-E1 osteoblastic cells was diminished by lowering the extracellular Cl(-) concentration ([Cl(-)](o)) in the culture medium. The lowered in [Cl(-)](o) increased the periods of the G(0...

journal_title：Biochemical and biophysical research communications

authors： Maki M,Miyazaki H,Nakajima K,Yamane J,Niisato N,Morihara T,Kubo T,Marunaka Y

更新日期：2007-10-05 00:00:00

abstract：:By the use of well-characterized antibodies against porcine dynorphin-A(1-8), an endogenous opioid peptide, and the use of a modified immunofluorescence microscopic technique, dynorphin-A(1-8) stained perikarya, nerve fibres, and nerve terminals were visualized in the rat duodenum. Dynorphin-A(1-8) immunoreactive peri...

journal_title：Biochemical and biophysical research communications

authors： Wolter HJ

更新日期：1985-03-15 00:00:00

abstract：:The availability of a human lymphoma cell line deficient in adenosine deaminase, adenosine kinase and methylthioadenosine phosphorylase enabled us to compare the effects of nucleoside transport inhibitors on the excretion of endogenously generated adenosine, deoxyadenosine and 5'-methylthioadenosine. The nucleoside tr...

journal_title：Biochemical and biophysical research communications

authors： Iizasa T,Kubota M,Carson DA

更新日期：1984-06-15 00:00:00

abstract：:Tumour-secreted vascular endothelial growth factor (VEGF) exerts a number of effects which are important in tumour pathology, including stimulation of angiogenesis and permeabilisation of tumour-associated vasculature. In this study we have examined the possibility that VEGF may also play an autocrine role in tumour g...

journal_title：Biochemical and biophysical research communications

authors： Liu B,Earl HM,Baban D,Shoaibi M,Fabra A,Kerr DJ,Seymour LW

更新日期：1995-12-26 00:00:00

abstract：:The distribution and intracellular translocation of AFB1 in various subcellular fractions was investigated in isolated hepatocytes by pulse-chase experiments. After labeling the hepatocytes with [3H]-AFB1 (14.5 nM) for 15 min, the highest concentration of [3H]-AFB1 was found in the cytosolic fraction where 66% was bou...

journal_title：Biochemical and biophysical research communications

authors： Ch'ih JJ,Devlin TM

更新日期：1984-07-18 00:00:00

abstract：:A new 1,25-dihydroxyvitamin D3 analog, 22-oxa-1,25(OH)2D3, which may have pharmaceutical use, e.g., in the treatment of psoriasis, was studied using cultured MG-63 human osteosarcoma cells. We found that the new compound binds to 1,25-dihydroxyvitamin D receptors and regulates receptor mRNA levels like the natural lig...

journal_title：Biochemical and biophysical research communications

authors： Valaja T,Mahonen A,Pirskanen A,Mäenpää PH

更新日期：1990-06-15 00:00:00

abstract：:Stimulation of leucine uptake by addition of concanavalin A, mediated by increase of intracellular free Ca2+ concentration [( Ca2+]), in lymphocytes (Mitsumoto, Y., Sato, K. and Mohri, T. (1988) Biochim. Biophys. Acta 968, 353-358) was abolished by N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) and chlorprom...

journal_title：Biochemical and biophysical research communications

authors： Sato K,Mitsumoto Y,Mohri T

更新日期：1988-06-16 00:00:00

abstract：:It has been shown that MDM2 inhibits the transcriptional and pro-apoptotic activities of p73 but does not promote its proteasomal degradation. In this study, we found that MDM2 indirectly induces the degradation of p73 through the interaction with Itch in HeLa cells. During adriamycin (ADR)-mediated apoptosis, p53 and...

journal_title：Biochemical and biophysical research communications

authors： Kubo N,Okoshi R,Nakashima K,Shimozato O,Nakagawara A,Ozaki T

更新日期：2010-12-17 00:00:00

abstract：:Dasatinib, a second-generation tyrosine kinase inhibitor, is indicated for the therapy of imatinib-resistant leukemia and also for the treatment of solid cancers. Here, we report a novel effect of dasatinib of inducing differentiation in normal human melanocytes. Treatment with dasatinib significantly increased the me...

journal_title：Biochemical and biophysical research communications

authors： Kang B,Kim Y,Park TJ,Kang HY

更新日期：2020-03-19 00:00:00

abstract：:The characterization of the genomic organization of the B2 bradykinin receptor gene enabled us to systematically search for polymorphic markers in this gene in a South German cohort (N = 179). We identified at least three polymorphic sites in each of the three exons existing: (i) in exon 1 next to the promoter region,...

journal_title：Biochemical and biophysical research communications

authors： Braun A,Kammerer S,Böhme E,Müller B,Roscher AA

更新日期：1995-06-06 00:00:00

abstract：:Human bladder carcinoma cell line EJ-1 secreted a protein of 30 kDa as a major component. This protein was purified from the serum-free conditioned medium of EJ-1. Its N-terminal amino acid sequence was identical to that of fibroblast-derived endothelial cell growth factor (f-ECGF), but there were differences in their...

journal_title：Biochemical and biophysical research communications

authors： Akaogi K,Okabe Y,Funahashi K,Yoshitake Y,Nishikawa K,Yasumitsu H,Umeda M,Miyazaki K

更新日期：1994-02-15 00:00:00

abstract：:Protein kinase D (PKD) has been established as a negative modulator of the c-Jun N-terminal kinase (JNK) signaling pathway. We previously demonstrated that induced expression of constitutively active PKD (PKD-S744/748E) that mimics phosphorylation by PKC is sufficient to attenuate epidermal growth factor (EGF) stimula...

journal_title：Biochemical and biophysical research communications

authors： Hurd C,Rozengurt E

更新日期：2003-03-21 00:00:00

abstract：:We have identified two types of homologous DNA pairing activity in mouse cell extracts by a strand-transfer assay. Both activities are separated from each other by anion-exchange chromatography; neither of them needs ATP. One requires magnesium ion and is stimulated by Escherichia coli single-stranded DNA binding prot...

journal_title：Biochemical and biophysical research communications

authors： Mishina Y,Shimokawa T,Kawasaki K,Arai N,Shibata T,Koyama H

更新日期：1992-06-30 00:00:00

abstract：:Acidic fibroblast growth factors (FGF1s) are heparin binding proteins that regulate a wide array of key cellular processes and are also candidates for promising biomedical applications. FGF1-based therapeutic applications are currently limited due to their inherent thermal instability and susceptibility to proteases. ...

journal_title：Biochemical and biophysical research communications

authors： Kerr R,Agrawal S,Maity S,Koppolu B,Jayanthi S,Suresh Kumar G,Gundampati RK,McNabb DS,Zaharoff DA,Kumar TKS

更新日期：2019-10-15 00:00:00

abstract：:Efonidipine is a dual L-/T- type calcium channel blocker with a slow onset of action and a long lasting effect that exibihits antihypertensive and nephroprotective effects. differs from most other DHPs which can induce reflex tachycardia. Efonidipine reduces blood pressure without decreasing cardiac output and exerts ...

journal_title：Biochemical and biophysical research communications

authors： Xu F,Xiong W,Huang Y,Shen J,Zhou D,Tang L

更新日期：2019-06-04 00:00:00

abstract：:To investigate the role of activation of c-Jun NH2-terminal kinase 1 (JNK1) in mediating cisplatin-induced apoptosis and the possibility of induction of JNK activity in triggering relation to DNA damage and drug resistance. We investigated the difference of cisplatin-induced activation of JNK pathway and H2O2 alterati...

journal_title：Biochemical and biophysical research communications

authors： Li F,Meng L,Zhou J,Xing H,Wang S,Xu G,Zhu H,Wang B,Chen G,Lu YP,Ma D

更新日期：2005-10-07 00:00:00

abstract：:Behcet's disease (BD) is a chronic relapsing inflammatory autoimmune disease characterized by recurrent oral and genital ulcers, skin legions and uveitis and its pathogenesis is not fully elucidated. Previously we identified that two novel susceptible SNPs are associated with BD. One is located in putative RNF39 promo...

journal_title：Biochemical and biophysical research communications

authors： Kurata R,Tajima A,Yonezawa T,Inoko H

更新日期：2013-06-21 00:00:00

abstract：:A dye displacement method was developed for determination of the affinities of compounds toward the active site of the detergent-solubilized sarcoplasmic reticulum CaATPase. Titration of the enzyme with 2',3'-O-(2,4,6-trinitrophenyl)-ADP resulted in a large absorbance difference in the visible spectrum. Subsequent add...

journal_title：Biochemical and biophysical research communications

authors： Coll RJ,Murphy AJ

更新日期：1986-07-31 00:00:00

abstract：:It was previously shown that rhodanese, inactivated with hydrogen peroxide, could only be reactivated in the presence of a reductant or the substrate thiosulfate if these reagents were added soon after inactivation and if the oxidant was removed. Here, we report on the facilitated reactivation (75%) of hydrogen peroxi...

journal_title：Biochemical and biophysical research communications

authors： Del Fierro D,Zardeneta G,Mendoza JA

更新日期：2000-08-02 00:00:00

abstract：:It is demonstrated that carbon fixation in photosynthesis is regulated in two kinetically coupled pathways involving the specialized pair of non-equivalent, enzyme-bound glycerate-3-P (3-PGA) molecules obtained from ribulose 1,5-bisphosphate (RuBP) carboxylation in the light. A non-cyclic pathway is suggested (reactio...

journal_title：Biochemical and biophysical research communications

authors： Fong FK,Butcher KA

更新日期：1988-01-15 00:00:00

abstract：:Recombinant scorpion anti-excitation peptide (rANEP) has previously been expressed using the pET32a system and purified via affinity chromatography. However, rANEP is expressed in BL21(DE3) cells as an inclusion body, and the affinity tag can not be removed. To overcome this problem, we used a variety of protein, DsbA...

journal_title：Biochemical and biophysical research communications

authors： Han T,Ming H,Deng L,Zhu H,Liu Z,Zhang J,Song Y

更新日期：2017-01-01 00:00:00

abstract：:Insulin administration attenuates cardiac ischemia-reperfusion apoptosis via activation of Akt-mediated cell-survival signaling. As p70s6 kinase is a cognate Akt-mediated phosphorylation target we evaluated whether p70s6 kinase activation is a functional requirement in insulin-mediated cell survival program during pos...

journal_title：Biochemical and biophysical research communications

authors： Jonassen AK,Mjøs OD,Sack MN

更新日期：2004-02-27 00:00:00

abstract：:CD36 expressed on adipocytes is thought to function as a fatty acid transporter (FAT). Here we report that adipocytes can endocytose and lysosomally degrade OxLDL, mainly mediated by CD36. Mouse 3T3-L1 preadipocytes showed marked increase in uptake and degradation of (125)I-OxLDL during their differentiation to adipoc...

journal_title：Biochemical and biophysical research communications

authors： Kuniyasu A,Hayashi S,Nakayama H

更新日期：2002-07-12 00:00:00

abstract：:Matrix metalloproteinases (MMPs) play a vital role in vasculature response to hemodynamic stimuli via the degradation of extracellular matrix substrates. In this study, we investigated the putative role of cyclic strain-induced endothelial MMP-2 (and MMP-9) expression and release in modulating bovine aortic smooth mus...

journal_title：Biochemical and biophysical research communications

authors： von Offenberg Sweeney N,Cummins PM,Birney YA,Redmond EM,Cahill PA

更新日期：2004-07-23 00:00:00