Metabolic stability of the LHRH antagonist antide to cell-surface peptidases.

abstract：:Transmissible spongiform encephalopathies are fatal neurodegenerative disorders thought to be transmitted by self-perpetuating conformational conversion of a neuronal membrane glycoprotein (PrP(C), for "cellular prion protein") into an abnormal state (PrP(Sc), for "scrapie prion protein"). Doppel (Dpl) is a protein th...

journal_title：Biochemical and biophysical research communications

authors： Erlich P,Cesbron JY,Lemaire-Vieille C,Curt A,Andrieu JP,Schoehn G,Jamin M,Gagnon J

更新日期：2008-01-18 00:00:00

abstract：:Anthrax-protective antigen is the central moiety of the anthrax toxin complex that mediates the entry of the other two toxin components, lethal factor and edema factor into the cells. It is also the main immunogen of the cell-free vaccine against anthrax. However, in addition to PA, the vaccine contains trace amounts ...

journal_title：Biochemical and biophysical research communications

authors： Ahuja N,Kumar P,Bhatnagar R

更新日期：2001-08-10 00:00:00

abstract：:PI3K activation is commonly observed in many human cancer cells. Survivin expression is elevated in cancer cells, and induced by some growth factors through PI3K activation. However, it is not clear whether PI3K activation is sufficient to induce survivin expression. To investigate the role of PI3K pathway in the regu...

journal_title：Biochemical and biophysical research communications

authors： Zhao P,Meng Q,Liu LZ,You YP,Liu N,Jiang BH

更新日期：2010-04-30 00:00:00

abstract：:We show here a novel non-viral strategy to transduce human cells by using an EBV-based vector system. The EBV-based vectors, the plasmid vectors carrying EBV oriP (origin for plasmid replication) and EBNA (EBV nuclear antigen) 1 gene from EBV genome, were combined with 2 gene delivery systems, i.e., cationic liposome ...

journal_title：Biochemical and biophysical research communications

authors： Satoh E,Osawa M,Tomiyasu K,Hirai H,Shimazaki C,Oda Y,Nakagawa M,Kondo M,Kinoshita S,Mazda O,Imanishi J

更新日期：1997-09-29 00:00:00

abstract：:The aim of this study was to investigate hormonal factors responsible for the huge increase in PRL receptors on the day of estrus in the rat mammary gland. For this purpose, ovariectomized rats were primed with E2 so as to reach a physiological serum concentration of E2 (21.5 +/- 1.2 pg/ml) and high PRL serum values (...

journal_title：Biochemical and biophysical research communications

authors： Guillaumot P,Sabbagh I,Bertrand J,Cohen H

更新日期：1986-03-28 00:00:00

abstract：:CYP1A1 is largely involved in carcinogenesis through the bioactivation of numerous procarcinogens. Exposure to environmental pollutants such as polycyclic aromatic hydrocarbons (PAHs) leads to induction of CYP1A1 via AhR pathway. We have previously demonstrated that fetal bovine serum (FBS) induces CYP1A1 gene transcr...

journal_title：Biochemical and biophysical research communications

authors： N'Guyen QB,Fallone F,Seree E,Fina F,Villard PH,Guigal N,De Meo M,Lacarelle B,Martin PM,Barra Y

更新日期：2002-09-20 00:00:00

abstract：:Genomic DNA of the phytopathogenic Erwinia chrysanthemi PY35 was partially digested with Sau3AI, ligated into the BamHI site of pBluescript II SK+, and introduced into E. coli. One clone that was able to hydrolyse carboxymethylcellulose and polygalacturonic acid was selected. A 2.9 kb fragment containing the pelL1 gen...

journal_title：Biochemical and biophysical research communications

authors： Park SR,Kim MK,Kim JO,Bae DW,Cho SJ,Cho YU,Yun HD

更新日期：2000-02-16 00:00:00

abstract：:Mab21 gene family members are required for embryonic development and sensory organ formation in both invertebrates and vertebrates. However, their mechanistic role on differentiation is largely unexplored. We report here the isolation of SIN-3 as a MAB-21 interacting molecule. sin-3 is co-expressed with mab-21 in the ...

journal_title：Biochemical and biophysical research communications

authors： Choy SW,Wong YM,Ho SH,Chow KL

更新日期：2007-07-06 00:00:00

abstract：:To investigate the mechanism underlying the antiatherogenic effect of estrogen, we examined the role of estrogen in the regulation of endothelin-1 (ET-1) production by cultured bovine carotid arterial endothelial cells. Treatment of the cells with 17beta-estradiol dose dependently inhibited gene expression and peptide...

journal_title：Biochemical and biophysical research communications

authors： Akishita M,Kozaki K,Eto M,Yoshizumi M,Ishikawa M,Toba K,Orimo H,Ouchi Y

更新日期：1998-10-09 00:00:00

abstract：:Nuclear envelope peptides of the rat ventral prostate in the molecular weight region 18,400 to 19,400 show marked androgen dependence. After castration these peptides disappear. Re-administration of testosterone restores them. They were not extracted by 0.1 M NaCl or 5% HClO4 but were partially extracted by 0.35 M NaC...

journal_title：Biochemical and biophysical research communications

authors： Venkatraman JT,Howell GM,Lefebvre YA

更新日期：1984-12-14 00:00:00

abstract：BACKGROUND:We investigated the role of the programmed cell death 4 (PDCD4) tumor suppressor gene in specimens of transitional cell carcinoma and of healthy individuals. METHODS:PDCD4 immunohistochemical expression was investigated in 294 cases in histologically proven transitional cell carcinoma in different tumorous ...

journal_title：Biochemical and biophysical research communications

authors： Fischer N,Göke F,Splittstösser V,Lankat-Buttgereit B,Müller SC,Ellinger J

更新日期：2012-01-06 00:00:00

abstract：:The mRNA of the mitochondrial uncoupling protein 2 (UCP2) was up-regulated by cryptorchidism, a testicular hyperthermic condition under which germ cells undergo severe apoptosis. We investigated whether UCP2 was able to protect germ cells from hyperthermia-induced apoptosis. UCP2 was predominantly present in elongate ...

journal_title：Biochemical and biophysical research communications

authors： Zhang K,Shang Y,Liao S,Zhang W,Nian H,Liu Y,Chen Q,Han C

更新日期：2007-08-24 00:00:00

abstract：:Enzymes belonging to the S9 family of prolyl oligopeptidases are of interest because of their pharmacological importance and have a non-catalytic β-propeller domain. In this study, we found that the oxidation of Met203, which lies on surface of the β-propeller domain, leads to change in the substrate specificity of er...

journal_title：Biochemical and biophysical research communications

authors： Tokai S,Bito T,Shimizu K,Arima J

更新日期：2017-05-27 00:00:00

abstract：:The "protein machine" for phage T4 homologous recombination has begun to be assembled in vitro. A particularly heavily studied reaction has been the uvsX protein (a RecA-like strand transferase)-mediated homologous pairing reaction between single and double-stranded DNAs, a key step in the recombination cycle in vivo....

journal_title：Biochemical and biophysical research communications

authors： Kodadek T

更新日期：1990-10-30 00:00:00

abstract：:Anders et al. (2011) [11] reported that cyclinD1/Cdk4 and cyclinD3/Cdk6 enhance the transcriptional activity of FOXM1c by phosphorylating its TAD. They defined 12 Cdk consensus sites as essential for the activation of FOXM1c by cyclinD1/Cdk4 and cyclinD3/Cdk6 and stated that the 12 Cdk-sites are positioned within the ...

journal_title：Biochemical and biophysical research communications

authors： Wierstra I

更新日期：2013-02-22 00:00:00

abstract：:When c-Src and v-Src were immunoprecipitated together from hamster fibroblasts transformed by Rous sarcoma virus containing v-src oncogene, the total Src activity was almost threefold higher compared to c-Src activity in the control cells. The activity of v-Src immunoprecipitated separately, however, accounting for on...

journal_title：Biochemical and biophysical research communications

authors： Tuhácková Z,Vojtechová M,Hlavácek J,Ruzzene M,Sovová V,Pinna LA

更新日期：2002-01-18 00:00:00

abstract：:The human pregnancy-specific glycoprotein (PSG) family consists of eleven closely related molecules mainly synthesized by placental syncytiotrophoblasts and whose function(s) are unknown. They belong to the carcinoembryonic antigen (CEA) family. As a step toward understanding PSG function, we have analysed 84 PSG cDNA...

journal_title：Biochemical and biophysical research communications

authors： Teglund S,Zhou GQ,Hammarström S

更新日期：1995-06-15 00:00:00

abstract：:The crystal structure of the mu and kappa opioid receptors has revealed dimeric structural arrangements. Mu-delta receptors heteromers also exist and we have identified discrete cytoplasmic regions in each receptor required for oligomer formation. In the carboxyl tail of the delta receptor we identified three glycine ...

journal_title：Biochemical and biophysical research communications

authors： O'Dowd BF,Ji X,O'Dowd PB,Nguyen T,George SR

更新日期：2012-06-15 00:00:00

abstract：:To elucidate the role of ornithine decarboxylase (ODC) in cancer cell invasion, we have compared the invasiveness of mouse mammary carcinoma, FM3A and its variant cell line, EXOD, which overproduces ODC. We have found that EXOD cells showed about 5.6-fold more invasiveness through a reconstituted basement membrane (Ma...

journal_title：Biochemical and biophysical research communications

authors： Kubota S,Yamada T,Kamei S,Seyama Y

更新日期：1995-03-28 00:00:00

abstract：:Nucleolar protein p40/EBP2 is a proliferation-associated antigen that interacts with Epstein-Barr virus nuclear antigen 1 (EBNA1) to maintain the Epstein-Barr virus (EBV) episomes. The yeast p40/EBP2 functions in the processing of 27S-A into 27S-B ribosomal RNA. The present study reports high evolutionary conservation...

journal_title：Biochemical and biophysical research communications

authors： Henning D,Valdez BC

更新日期：2001-05-04 00:00:00

abstract：:Tooth development is a highly organized process characterized by reciprocal interactions between epithelium and mesenchyme. However, the expression patterns and functions of molecules involved in mouse tooth development are unclear from the viewpoint of explaining human dental malformations and anomalies. Here, we sho...

journal_title：Biochemical and biophysical research communications

authors： Miyado M,Ogi H,Yamada G,Kitoh J,Jogahara T,Oda S,Sato I,Miyado K,Sunohara M

更新日期：2007-11-16 00:00:00

abstract：:A protein of Mr 16,000 (protein 16 K) which tightly binds to DNA has been isolated from E. coli. The amino acid composition and amino-terminal amino acid sequence of this protein have been determined. On the basis of its physico-chemical characteristics the protein 16 K was shown to be identical to the protein H1 [Cuk...

journal_title：Biochemical and biophysical research communications

authors： Laine B,Sautiere P,Spassky A,Rimsky S

更新日期：1984-03-30 00:00:00

abstract：:Explaining why type I collagens are preferentially preserved in the geological time scale remains a challenge. Several pieces of evidence indicate that its rich content in the bone and its unique, stable structure played key roles in its preservation. By considering the distinct thermal stability of amino acids, we re...

journal_title：Biochemical and biophysical research communications

authors： Wang SY,Cappellini E,Zhang HY

更新日期：2012-05-25 00:00:00

abstract：:A novel human gene containing an ankyrin repeat and BTB/POZ domains (BPOZ) was isolated from a human leukocyte cDNA library. The cDNA sequence contains an open reading frame of 1434 bp that encodes 478 amino acid residues with a predicted molecular mass of 53.9 kDa. Sequence pattern analysis shows that BPOZ contains a...

journal_title：Biochemical and biophysical research communications

authors： Dai KS,Wei W,Liew CC

更新日期：2000-07-14 00:00:00

abstract：:We quantified the damage yields produced in plasmid DNA by γ-irradiation in the presence of low concentrations (10-100 μM) of ascorbic acid, which is a major antioxidant in living systems, to clarify whether it chemically repairs radiation damage in DNA. The yield of DNA single strand breaks induced by irradiation was...

journal_title：Biochemical and biophysical research communications

authors： Hata K,Urushibara A,Yamashita S,Shikazono N,Yokoya A,Katsumura Y

更新日期：2013-05-03 00:00:00

abstract：:The recent discovery that mutation Asn21 --> Ile in the human cationic trypsinogen (Tg) is associated with hereditary pancreatitis has brought into focus the functional role of amino acid 21 in mammalian Tgs. In the present paper, the effect of mutations Thr21 --> Asn and Thr21 --> Ile on the Ca(2+) dependence of zymo...

journal_title：Biochemical and biophysical research communications

authors： Sahin-Tóth M,Tóth M

更新日期：2000-08-28 00:00:00

abstract：:Besides its well-established oncosuppressor activity, the role of p53 in regulating metabolic pathways has been recently identified. Nevertheless, the function of p53 with respect to insulin resistance appears highly controversial. To address this issue, we investigated the expression of p53 in experimental model of i...

journal_title：Biochemical and biophysical research communications

authors： Geng S,Zhu W,Wang S,Xie C,Li X,Wu J,Li Y,Chen Y,Wang X,Meng Y,Zhang Q,Chen J,Zhong C

更新日期：2018-01-15 00:00:00

abstract：:The extracellular microenvironment plays a key role in regulation of cellular functions and growth control. We show here that membrane-type 1 matrix metalloproteinase (MT1-MMP) acts as a growth promoter in confluent culture. When MT1-MMP was silenced in HT1080 fibrosarcoma cells, cells created three dimensional (3D) f...

journal_title：Biochemical and biophysical research communications

authors： Takino T,Guo L,Domoto T,Sato H

更新日期：2013-07-05 00:00:00

abstract：:The Drosophila Toll-1 receptor is involved in embryonic development, innate immunity, and tissue homeostasis. Currently, as a ligand for the Toll-1 receptor, only Spätzle (Spz) has been identified and characterized. We previously reported that Drosophila larva-derived tissue extract contains ligand activity for the To...

journal_title：Biochemical and biophysical research communications

authors： Nonaka S,Kawamura K,Hori A,Salim E,Fukushima K,Nakanishi Y,Kuraishi T

更新日期：2018-11-30 00:00:00

abstract：:Transcriptional mechanisms controlling human UCP3 gene expression in skeletal muscle remain poorly understood. Experiments based on plasmid electrotransfer into tibialis anterior muscle of C57/BL6 male mice were set up in order to functionally analyze the hUCP3 gene promoter. These transfection experiments showed that...

journal_title：Biochemical and biophysical research communications

authors： Riquet FB,Rodriguez M,Guigal N,Dromaint S,Naime I,Boutin JA,Galizzi JP

更新日期：2003-11-21 00:00:00