Characterization of Erwinia chrysanthemi PY35 cel and pel gene existing in tandem and rapid identification of their gene products.

abstract：:Previously, we reported that metabolism of arachidonic acid through the 5-lipoxygenase (5-LOX) pathway plays an important role in the survival and growth of human prostate cancer cells. Inhibition of 5-LOX by pharmacological inhibitors triggers apoptosis in prostate cancer cells within hours of treatment, which is pre...

journal_title：Biochemical and biophysical research communications

authors： Sundaram S,Ghosh J

更新日期：2006-01-06 00:00:00

abstract：:Liver fibrosis and cirrhosis result from uncontrolled secretion and accumulation of extracellular matrix (ECM) proteins by hepatic stellate cells (HSCs) that are activated by liver injury and inflammation. Despite the progress in understanding the biology liver fibrogenesis and the identification of potential targets ...

journal_title：Biochemical and biophysical research communications

authors： Karthikeyan S,Potter JJ,Geschwind JF,Sur S,Hamilton JP,Vogelstein B,Kinzler KW,Mezey E,Ganapathy-Kanniappan S

更新日期：2016-01-15 00:00:00

abstract：:Cytoplasmic polyadenylation element binding (CPEB) proteins are RNA-binding proteins involved in translational regulation of the specific target mRNAs and control function of various organs including brain, liver and hematopoietic system. However, the role of CPEB proteins during osteoclast differentiation remains unc...

journal_title：Biochemical and biophysical research communications

authors： Arasaki Y,Li M,Akiya T,Nozawa I,Ezura Y,Hayata T

更新日期：2020-08-06 00:00:00

abstract：:Cytochrome (cyt) c can uncouple from the respiratory chain following mitochondrial stress and catalyze lipid peroxidation. Accumulating evidence shows that this phenomenon impairs mitochondrial respiratory function and also initiates the apoptotic cascade. Therefore, under certain conditions a pharmacological approach...

journal_title：Biochemical and biophysical research communications

authors： Yin H,Vergeade A,Shi Q,Zackert WE,Gruenberg KC,Bokiej M,Amin T,Ying W,Masterson TS,Zinkel SS,Oates JA,Boutaud O,Roberts LJ 2nd

更新日期：2012-06-29 00:00:00

abstract：:This report examines the balance of positive and negative adipogenic factors in a line of immortalized 243 embryonic fibroblasts that undergo spontaneous preadipocyte differentiation. Control of adipogenesis reflects the interplay of factors that promote or inhibit expression of C/EBPalpha and PPARgamma. The 243 cells...

journal_title：Biochemical and biophysical research communications

authors： Bennett CN,Hodge CL,MacDougald OA,Schwartz J

更新日期：2003-02-28 00:00:00

abstract：:Adult height (stature), as an important parameter of human physical development, has been studied in many populations. Recently, we reported a whole genome scan of height on a sample of 630 Caucasian subjects from 53 human pedigrees. Two chromosome regions, 6q24-25 and 7q31.3-36, achieved low linkage signals (multipoi...

journal_title：Biochemical and biophysical research communications

authors： Yang YJ,Liu YZ,Li MX,Lei SF,Chen XD,Sun X,Deng HW

更新日期：2005-10-07 00:00:00

abstract：:Golgi matrix protein 130 (GM130), encoded by GOLGA2, is the classical marker of the Golgi apparatus. It plays important roles in various mitotic events, such as interacting with importin-alpha and liberating spindle assembly factor TPX2 to regulate mitotic spindle formation. A previous study showed that in vitro knock...

journal_title：Biochemical and biophysical research communications

authors： Jiang Y,Liu Y,Han F,Zhou J,Zhang X,Xu J,Yu Z,Zhao S,Gao F,Zhao H

更新日期：2020-11-12 00:00:00

abstract：:Deinococcus radiodurans is an extremophilic bacterium well-known for its extraordinary resistance to ionizing radiation and other DNA damage- and oxidative stress-generating agents. In addition to its efficient DNA damage repair and oxidative stress resistance mechanisms, protein family expansions and stress-induced g...

journal_title：Biochemical and biophysical research communications

authors： Zhang J,Zhao L,Seo HS,Jung JH,Choi JI,Kim MK,Lim S

更新日期：2019-05-28 00:00:00

abstract：:Pre-treatment of neutrophils with either pertussis or cholera toxins does not inhibit neutrophil activation by surface bound IgG. In contrast, pretreatment with the phorbol ester, phorbol myristate acetate, results in a dose dependent inhibition of degranulation by surface bound IgG. This inhibition is similar to that...

journal_title：Biochemical and biophysical research communications

authors： Blackburn WD Jr,Heck LW

更新日期：1989-11-15 00:00:00

abstract：:Glycosyl-phosphatidylinositol (GPI) anchored proteins are surveyed in two insulin sensitive cell types by surface labeling and phospholipase C-induced release into the medium. Serum starvation selectively increases both the number and intensity of a subset of GPI-anchored proteins. After serum starvation, loss of cell...

journal_title：Biochemical and biophysical research communications

authors： Lisanti MP,Darnell JC,Chan BL,Rodriguez-Boulan E,Saltiel AR

更新日期：1989-10-31 00:00:00

abstract：:The effects of fibroblast growth factor (FGF) on testicular aromatase activity has been studied using primary cultures of porcine Leydig cells. After culture for 3 days in the absence or presence of FGF, the ability of the cells to produce estrogen was examined in a 4h-test period in which either (a) hCG (10(-9) M) or...

journal_title：Biochemical and biophysical research communications

authors： Raeside JI,Berthelon MC,Sanchez P,Saez JM

更新日期：1988-02-29 00:00:00

abstract：:Retroviruses and retrotransposons depend on their host cells to complete their replication cycles. In many cases, the viral step of reverse transcription is blocked when host cells are arrested in their cell cycle and this block is only released when the host cell resumes division. It has previously been shown that a ...

journal_title：Biochemical and biophysical research communications

authors： Karst SM,Sadeghi N,Menees TM

更新日期：1999-01-27 00:00:00

abstract：:Rats were fed for 15 days a diet containing ammonium acetate (20% w/w) and then injected i. p. with ammonium acetate (7 mmol/Kg). Only 1 out of 18 control rats but 9 of 18 rats fed ammonium survived, indicating a protective effect of ammonium ingestion against an acute ammonia challenge. Blood ammonia returned to norm...

journal_title：Biochemical and biophysical research communications

authors： Miñana MD,Felipo V,Grisolía S

更新日期：1988-06-30 00:00:00

abstract：:Baeyer-Villiger monooxygenase (BVMO) catalyzes insertion of an oxygen atom into aliphatic or cyclic ketones with high regioselectivity. The BVMOs from Parvibaculum lavamentivorans (BVMOParvi) and Oceanicola batsensis (BVMOOcean) are interesting because of their homologies, with >40% sequence identity, and reaction wit...

journal_title：Biochemical and biophysical research communications

authors： Nguyen TD,Choi GE,Gu DH,Seo PW,Kim JW,Park JB,Kim JS

更新日期：2019-05-07 00:00:00

abstract：:The solubilized [3H]ryanodine receptor from cardiac sarcoplasmic reticulum was centrifuged through linear sucrose gradients. A single peak of radioactivity with apparent sedimentation coefficient of approximately 30S specifically comigrated with a high molecular weight protein of apparent relative molecular mass appro...

journal_title：Biochemical and biophysical research communications

authors： Lai FA,Anderson K,Rousseau E,Liu QY,Meissner G

更新日期：1988-02-29 00:00:00

abstract：:1,25-Dihydroxyvitamin D(3) [1,25(OH)(2) D(3)] exerts its biological effects by binding to the vitamin D receptor (VDR), which binds in turn to the vitamin D response elements located in the target gene's promoter. We have previously demonstrated that VDR binds in vitro with high affinity to the 5'-flanking sequence of...

journal_title：Biochemical and biophysical research communications

authors： Seoane S,Alonso M,Segura C,Pérez-Fernández R

更新日期：2002-03-22 00:00:00

abstract：:Computer-based approaches identified PTE2 as a candidate human peroxisomal acyl-CoA thioesterase gene. The PTE2 gene product is highly similar to the rat cytosolic and mitochondrial thioesterases, CTE1 and MTE1, respectively, and terminates in a tripeptide sequence, serine-lysine-valine(COOH), that resembles the conse...

journal_title：Biochemical and biophysical research communications

authors： Jones JM,Gould SJ

更新日期：2000-08-18 00:00:00

abstract：:NAD+ is a co-enzyme in redox reactions and a substrate required for activity of various enzyme families, including sirtuins and poly(ADP-ribose) polymerases. Dietary supplementation of NAD+ precursors nicotinamide mononucleotide (NMN) or nicotinamide riboside (NR) protects against metabolic disease, neurodegenerative ...

journal_title：Biochemical and biophysical research communications

authors： Fan R,Cui J,Ren F,Wang Q,Huang Y,Zhao B,Wei L,Qian X,Xiong X

更新日期：2018-06-02 00:00:00

abstract：:Tyrosine hydroxylase (TH) is the rate-limiting enzyme in catecholamine biosynthesis, and its N-terminus plays a critical role in the intracellular stability of the enzyme. In the present study, we investigated the mechanism by which the N-terminal region of TH affects this stability. TH molecules phosphorylated at the...

journal_title：Biochemical and biophysical research communications

authors： Nakashima A,Mori K,Kaneko YS,Hayashi N,Nagatsu T,Ota A

更新日期：2011-04-08 00:00:00

abstract：:The Fru-6-P/Fru-2,6-P2 exchange reaction of rat liver 6-phosphofructo 2-kinase/fructose 2,6-bisphosphatase was almost entirely dependent on the presence of Pi. This exchange was not due to a reversal of the bisphosphatase nor to trace amounts of adenine nucleotide in the enzyme. Exchange activity was maximal at pH 7, ...

journal_title：Biochemical and biophysical research communications

authors： El-Maghrabi MR,Pate TM,Pilkis SJ

更新日期：1984-09-17 00:00:00

abstract：:In this report we present evidence that a guanine nucleotide regulatory protein, Gi, mediates opiate action in the rat brain striatum. Opiates inhibit basal adenylate cyclase activity in rat brain striatum. This effect on adenylate cyclase is dose-dependently attenuated by pretreatment of membranes with pertussis toxi...

journal_title：Biochemical and biophysical research communications

authors： Abood ME,Law PY,Loh HH

更新日期：1985-03-15 00:00:00

abstract：:Stellate cell profibrotic gene induction and transdifferentiation are central events in liver fibrosis. Oxidative stress has been implicated as an activator of the transcription factors Nrf2 and AP-1 through shared kinase signaling pathways that also purportedly contribute to stellate cell activation. The present stud...

journal_title：Biochemical and biophysical research communications

authors： Reichard JF,Petersen DR

更新日期：2004-09-24 00:00:00

abstract：:Application of delta-aminolevulinic acid (ALA) results in the endogenous accumulation of protoporphyrin IX and is a useful approach in the photodynamic therapy (PDT) of cancers. To investigate the role of nitric oxide (NO) in the specific accumulation of protoporphyrin and ALA-induced PDT of cancerous cells, we transf...

journal_title：Biochemical and biophysical research communications

authors： Yamamoto F,Ohgari Y,Yamaki N,Kitajima S,Shimokawa O,Matsui H,Taketani S

更新日期：2007-02-16 00:00:00

abstract：:The product of the spontaneous dimerization and decarboxylation of aminoethylcysteine ketimine (simply named the dimer in this note) has been investigated for a possible biochemical activity. It has been found that the dimer inhibits the ADP-dependent oxidation of NAD(+)-linked substrates in rat liver mitochondria and...

journal_title：Biochemical and biophysical research communications

authors： Pecci L,Montefoschi G,Fontana M,Cavallini D

更新日期：1994-03-15 00:00:00

abstract：:Endothelin, a vasoconstrictor peptide, plays important roles not only in the mammalian circulatory system but also in non-mammalian systems, such as the gill lamellar vascular network with complex structural characteristics. Here, we show that (i) the contraction of pillar cells that delimit the lamellar vasculature i...

journal_title：Biochemical and biophysical research communications

authors： Sultana N,Nag K,Kato A,Hirose S

更新日期：2007-03-30 00:00:00

abstract：:The alpha-ketoglutarate dehydrogenase complex of Escherichia coli can bind up to 12 dimers of dihydrolipoyl dehydrogenase (E3) besides those already present. Maximal activity does not increase, however, when surplus E3 is present. This observation was previously interpreted to mean that the excess enzyme is inactive. ...

journal_title：Biochemical and biophysical research communications

authors： Wagenknecht T,Francis N,DeRosier D

更新日期：1986-03-28 00:00:00

abstract：:Activated botulinum D toxin ADP-ribosylates a 22 kDa molecular weight protein in homogenates obtained by sonication of a suspension of rabbit peritoneal neutrophils. The ADP-ribosylation catalyzed by activated botulinum D toxin is inhibited in homogenates obtained from cells pretreated with the toxin, suggesting that ...

journal_title：Biochemical and biophysical research communications

authors： Mege JL,Volpi M,Becker EL,Sha'afi RI

更新日期：1988-04-29 00:00:00

abstract：:Accumulating evidence indicates that epigenetic aberrations have a role in the pathogenesis of rheumatoid arthritis (RA). However, reports on histone modifications are as yet quite limited in RA. Interleukin (IL)-6 is an inflammatory cytokine which is known to be involved in the pathogenesis of RA. Here we report the ...

journal_title：Biochemical and biophysical research communications

authors： Wada TT,Araki Y,Sato K,Aizaki Y,Yokota K,Kim YT,Oda H,Kurokawa R,Mimura T

更新日期：2014-02-21 00:00:00

abstract：:The Arabidopsis wall-associated receptor kinase, WAK1, is a member of WAK family that links the plasma membrane to the extracellular matrix. A glycine-rich secreted protein, AtGRP-3, was previously shown to regulate WAK1 functions through binding to the extracellular domain of WAK1. In this study, we sought to determi...

journal_title：Biochemical and biophysical research communications

authors： Yang EJ,Oh YA,Lee ES,Park AR,Cho SK,Yoo YJ,Park OK

更新日期：2003-06-13 00:00:00

abstract：:IL-10 producing B (B10) cells, a subset of regulatory B (Breg) cells, produce IL-10 and play immunosuppressive roles in antitumor immunity. B10 cells are associated with enhanced tumor-aggressiveness and a poorer prognosis. To specifically inhibit the IL-10 secreted by B cells, we constructed the recombinant plasmid p...

journal_title：Biochemical and biophysical research communications

authors： Zhao R,Liu M,Li X,Chen H,Deng J,Huang C,Zhang XL,Pan Q

更新日期：2018-12-02 00:00:00