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Pertussis toxin treatment modifies opiate action in the rat brain striatum.

Abstract：

:In this report we present evidence that a guanine nucleotide regulatory protein, Gi, mediates opiate action in the rat brain striatum. Opiates inhibit basal adenylate cyclase activity in rat brain striatum. This effect on adenylate cyclase is dose-dependently attenuated by pretreatment of membranes with pertussis toxin, which ADP-ribosylates a protein with a molecular mass of 41,000 daltons. This protein co-migrates with the GTP-binding subunit of Gi, which mediates inhibition of adenylate cyclase. Several brain regions were compared for the extent of radiolabeling and effects on adenylate cyclase activity. Although Gi was found in each region examined, opiate inhibition of adenylate cyclase is clearly seen only in the striatum.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Abood ME,Law PY,Loh HH

doi

10.1016/s0006-291x(85)80185-6

subject

Has Abstract

pub_date

1985-03-15 00:00:00

pages

477-83

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(85)80185-6

journal_volume

127

pub_type

杂志文章

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