Loss of GM130 does not impair oocyte meiosis and embryo development in mice.

abstract：:Sepsis-induced muscle proteolysis mainly reflects ubiquitin-proteasome-dependent protein degradation. The effect of in vivo administration of a proteasome inhibitor on muscle protein breakdown during sepsis is not known. We treated rats with the proteasome inhibitor N-benzyloxycarbonyl-Ile-Glu-(O-t-butyl)-Ala-leucinal...

journal_title：Biochemical and biophysical research communications

authors： Fischer D,Gang G,Pritts T,Hasselgren PO

更新日期：2000-04-02 00:00:00

abstract：:Activating Transcription Factor 2 (ATF2) is a member of the ATF/CREB bZIP family of transcription factors and an oncogene in prostate cancer. ATF2 has been reported to be a critical substrate of the CUL3-SPOP-RBX1 E3 ubiquitin ligase complex and the recurrent somatic mutation of SPOP has been believed to be a key feat...

journal_title：Biochemical and biophysical research communications

authors： Geng L,Chen X,Zhang M,Luo Z

更新日期：2020-03-26 00:00:00

abstract：:Glutathione (GSH) is the most abundant non-protein thiol that buffers reactive oxygen species in the brain. GSH does not reduce nitroxides directly, but in the presence of ascorbates, addition of GSH increases ascorbate-induced reduction of nitroxides. In this study, we used electron paramagnetic resonance (EPR) imagi...

journal_title：Biochemical and biophysical research communications

authors： Emoto MC,Matsuoka Y,Yamada KI,Sato-Akaba H,Fujii HG

更新日期：2017-04-15 00:00:00

abstract：:Quantitative and qualitative analyses of mRNAs from a small number of cells are extremely important for studies on gene expression in various physiological and pathological conditions in multicellular organisms. We present here an effective method for high-fidelity global mRNA amplification for in vivo gene expression...

journal_title：Biochemical and biophysical research communications

authors： Aoyagi K,Tatsuta T,Nishigaki M,Akimoto S,Tanabe C,Omoto Y,Hayashi Si,Sakamoto H,Sakamoto M,Yoshida T,Terada M,Sasaki H

更新日期：2003-01-24 00:00:00

abstract：:Nowadays, connexin (Cx) 36 is considered the sole gap junction protein expressed in pancreatic beta cells. In the present research we investigated the expression of Cx30.2 mRNA and protein in mouse pancreatic islets. Cx30.2 mRNA and protein were identified in isolated islet preparations by qRT-PCR and Western blot, re...

journal_title：Biochemical and biophysical research communications

authors： Coronel-Cruz C,Hernández-Tellez B,López-Vancell R,López-Vidal Y,Berumen J,Castell A,Pérez-Armendariz EM

更新日期：2013-09-06 00:00:00

abstract：:BRAF25 is an alternatively spliced protein of BRAF35 (see associated paper). We have mapped the BRAF25 gene to chromosome sub-band 19p13.3, a region where loss of chromosomal heterozygosity has been reported in about 50% of ovarian cancers. Because of the high incidence of genetic links of prostate cancer to breast an...

journal_title：Biochemical and biophysical research communications

authors： Wang C,McCarty IM,Balazs L,Li Y,Steiner MS

更新日期：2002-07-05 00:00:00

abstract：:A cDNA clone encoding human aldosterone synthase cytochrome P-450 (P-450aldo) has been isolated from a cDNA library derived from human adrenal tumor of a patient suffering from primary aldosteronism. The insert of the clone contains an open reading frame encoding a protein of 503 amino acid residues together with a 3 ...

journal_title：Biochemical and biophysical research communications

authors： Kawainoto T,Mitsuuchi Y,Ohnishi T,Ichikawa Y,Yokoyama Y,Sumimoto H,Toda K,Miyahara K,Kuribayashi I,Nakao K

更新日期：1990-11-30 00:00:00

abstract：:Ectodomain shedding of membrane receptors and ligands carried out by ADAMs (A disintegrin and metalloprotease) plays a major role in several signaling pathways, including Notch. The grounds of substrate recognition, however, are poorly understood. We demonstrate that a recombinant protein corresponding to the juxtamem...

journal_title：Biochemical and biophysical research communications

authors： Coglievina M,Guarnaccia C,Zlatev V,Pongor S,Pintar A

更新日期：2013-03-22 00:00:00

abstract：:The paired-like homeobox-containing gene Ehox plays a role in embryonic stem cell differentiation and is highly expressed in the developing placenta and thymus. To understand the mechanisms of regulation of Ehox gene expression, the 5'-flanking region of the Ehox gene was isolated from a mouse BAC library. 5'-RACE ana...

journal_title：Biochemical and biophysical research communications

authors： Lee WK,Kim YM,Malik N,Ma C,Westphal H

更新日期：2006-03-03 00:00:00

abstract：:The presence of calcium-dependent proteinase in plants was investigated using soluble proteins from Arabidopsis root cultures. Calcium increased the proteolytic activity by two to three fold. Calcium-stimulated proteolytic activity was inhibited by different protease inhibitors. The highest inhibition (79%) of calcium...

journal_title：Biochemical and biophysical research communications

authors： Reddy AS,Safadi F,Beyette JR,Mykles DL

更新日期：1994-03-30 00:00:00

abstract：:Two different clones, named rEP3A (approximately 2.2 kb) and rEP3B (approximately 5.2 kb), were isolated from a rat kidney cDNA library by a homology screening approach. rEP3A was shown to encode the rat kidney prostaglandin E receptor EP3 subtype (rEP3A receptor) (Takeuchi, K. et al. B.B.R.C. (1993) 194: 885). rEP3B ...

journal_title：Biochemical and biophysical research communications

authors： Takeuchi K,Takahashi N,Abe T,Abe K

更新日期：1994-03-15 00:00:00

abstract：:Neurofibromatosis type 1 is a common genetic disease that causes nervous system tumors, and cognitive deficits. It is due to mutations within the NF1 gene, which encodes the Nf1 protein. Nf1 has been shown to be involved in the regulation of Ras, cAMP and actin cytoskeleton dynamics. In this study, using immunofluores...

journal_title：Biochemical and biophysical research communications

authors： Godin F,Villette S,Vallée B,Doudeau M,Morisset-Lopez S,Ardourel M,Hevor T,Pichon C,Bénédetti H

更新日期：2012-02-24 00:00:00

abstract：:The results presented in this paper demonstrate that the potentiation of phagocytosis of erythrocyte (E) IgG by TNF-alpha or PMA is not due to an oxygen-dependent mechanism. In fact, the potentiation of phagocytosis occurs normally in human neutrophils 1) when the respiratory burst is inhibited by diphenyleneiodonium,...

journal_title：Biochemical and biophysical research communications

authors： Della Bianca V,Grzeskowiak M,Renzi E,Rossi F

更新日期：1993-06-30 00:00:00

abstract：:Tyrosine-specific phosphorylated proteins found exclusively on the cell surface of human astrocytomas were previously identified with murine monoclonal antibodies, designated as GA-17, GB-4 and GC-3. The purpose of this study was to further characterize the antigens and investigate the relationship between them and c-...

journal_title：Biochemical and biophysical research communications

authors： Kondo S,Miyatake S,Matsumoto M,Nakatsu S,Iwasaki K,Oda Y,Kikuchi H,Namba Y

更新日期：1992-01-31 00:00:00

abstract：:Streptococcus mutans, a member of the viridans streptococci, is the etiologic agent of dental caries and is also a causative agent of subacute infective endocarditis. The generation of proteolytic molecules, such as plasmin, may be important in the pathogenesis of endocarditis caused by S. mutans. In this study, we de...

journal_title：Biochemical and biophysical research communications

authors： Jones MN,Holt RG

更新日期：2004-09-10 00:00:00

abstract：BACKGROUND:When an activated muscle is rapidly stretched, force rises and peaks while muscle lengthens. The peak force is normally called critical-force (Pc). The mechanism behind this increase in force is not well understood, but it has been associated with crossbridges operating in different states. METHODS:Myofibri...

journal_title：Biochemical and biophysical research communications

authors： Minozzo FC,Altman D,Rassier DE

更新日期：2015-08-07 00:00:00

abstract：:Lysine-specific demethylase 1 (LSD1) is upregulated in many cancers, especially neuroblastoma. We set out to explore whether geranylgeranoic acid (GGA) inhibits LSD1 activity by using recombinant human LSD1. GGA inhibited LSD1 activity with IC50 similar to that of the clinically used drug tranylcypromine. In human neu...

journal_title：Biochemical and biophysical research communications

authors： Sakane C,Okitsu T,Wada A,Sagami H,Shidoji Y

更新日期：2014-01-31 00:00:00

abstract：:Hippo pathway regulates cell proliferation and differentiation. Yes-associated protein (Yap) and transcriptional coactivator with PDZ-binding motif (Taz) are effectors of Hippo pathway. The function of Yap/Taz in embryonic liver development has yet to be reported. Here yap1 and taz were found expressed in liver and ot...

journal_title：Biochemical and biophysical research communications

authors： Yi X,Yu J,Ma C,Li L,Luo L,Li H,Ruan H,Huang H

更新日期：2018-09-03 00:00:00

abstract：:α-Dystroglycan is an extracellular adhesion protein that is known to interact with different ligands. The interaction is thought to stabilize the integrity of the plasma membrane. The N-terminal part of α-dystroglycan may be proteolytically processed to generate a small 38 kDa protein (α-DG-N). The physiological signi...

journal_title：Biochemical and biophysical research communications

authors： Hesse C,Johansson I,Mattsson N,Bremell D,Andreasson U,Halim A,Anckarsäter R,Blennow K,Anckarsäter H,Zetterberg H,Larson G,Hagberg L,Grahn A

更新日期：2011-09-02 00:00:00

abstract：:In pulse-chase experiments ([35S]Met as radioactive label) 4 intracellular forms of the alpha-subunit (apparent molecular weights of 11, 16.5, 19.5, and 23.4 kDa) were observed whereas almost no label was incorporated into the beta-subunit. The 23.4 kDa form was secreted as free alpha-subunit, the others were precurso...

journal_title：Biochemical and biophysical research communications

authors： Hilf G,Merz WE

更新日期：1989-02-28 00:00:00

abstract：:Glycogen-storage disease type II (GSD II, acid maltase deficiency, Pompe's disease) is caused by defects in the lysosomal acid alpha-glucosidase (GAA) gene. Clinically, patients with the severe infantile form of GSD II have muscle weakness and cardiomyopathy eventually leading to death before the age of two years. Pat...

journal_title：Biochemical and biophysical research communications

authors： Nicolino M,Puech JP,Letourneur F,Fardeau M,Kahn A,Poenaru L

更新日期：1997-06-09 00:00:00

abstract：:Human bladder carcinoma cell line EJ-1 secreted a protein of 30 kDa as a major component. This protein was purified from the serum-free conditioned medium of EJ-1. Its N-terminal amino acid sequence was identical to that of fibroblast-derived endothelial cell growth factor (f-ECGF), but there were differences in their...

journal_title：Biochemical and biophysical research communications

authors： Akaogi K,Okabe Y,Funahashi K,Yoshitake Y,Nishikawa K,Yasumitsu H,Umeda M,Miyazaki K

更新日期：1994-02-15 00:00:00

abstract：:We have used a tissue culture system based on breast carcinoma cell lines to investigate a large number of naturally occurring compounds and beverages for steroid hormone agonist and antagonist activity. The cell lines used, T-47D and BT-474, produce prostate specific antigen (PSA) upon stimulation with androgens, pro...

journal_title：Biochemical and biophysical research communications

authors： Rosenberg RS,Grass L,Jenkins DJ,Kendall CW,Diamandis EP

更新日期：1998-07-30 00:00:00

abstract：:Familial exudative vitreoretinopathy (FEVR) is a congenital hereditary, bilateral eye disorder which affects both retina and the vitreous body. As a first step toward the identification of the gene responsible for the X-linked disorder, we report here the results of DNA analyses from the patients and their parents of ...

journal_title：Biochemical and biophysical research communications

authors： Shastry BS,Trese MT

更新日期：1993-06-15 00:00:00

abstract：:Most proteins synthesized in cytoplasm target to mitochondria through sequences at their amino termini. However, a previous study suggests that the native carboxyl terminus of ISP6 might be critical of its specific delivery. Here we investigated the sequence directing ISP6 to yeast mitochondrial outer membrane. Unlike...

journal_title：Biochemical and biophysical research communications

authors： Cao W,Douglas MG

更新日期：1996-07-16 00:00:00

abstract：:maf is a family of oncogenes, originally identified from the avian oncogenic retrovirus AS42, which encodes a nuclear bZip transcription factor protein. It has been reported that maf family genes have critical roles in embryological development and cellular differentiation. In this study, the distribution of maf-1 gen...

journal_title：Biochemical and biophysical research communications

authors： Imaki J,Onodera H,Tsuchiya K,Imaki T,Mochizuki T,Mishima T,Yamashita K,Yoshida K,Sakai M

更新日期：2000-06-16 00:00:00

abstract：:A spontaneous lymphoma was detected in mice, which was caused by a recessive autosomal mutation. The genetic basis was revealed to be a 5-bp deletion at the splicing donor site of the first intron of the FasL gene, resulting in aberrant transcripts coding for non-functional proteins. This mutation of the FasL gene cau...

journal_title：Biochemical and biophysical research communications

authors： Wang CC,Zeng Q,Hwang LA,Guo K,Li J,Liew HC,Hong W

更新日期：2006-10-13 00:00:00

abstract：:Communication between receptor tyrosine kinase and G protein-coupled receptor (GPCR)-mediated signaling is recognized as a common integrator linking diverse aspects of intracellular signaling systems. Here, we report that G protein-coupled beta-adrenergic receptor activation leading to stimulation of salivary phosphol...

journal_title：Biochemical and biophysical research communications

authors： Slomiany BL,Slomiany A

更新日期：2004-05-21 00:00:00

abstract：:Steatosis is an important clinical manifestation of hepatitis C virus (HCV) infection. The molecular mechanisms of HCV-associated steatosis are not well understood. Sterol regulatory element-binding protein-1c (SREBP-1c) is a key transcription factor which activates the transcription of lipogenic genes. Here we showed...

journal_title：Biochemical and biophysical research communications

authors： Xiang Z,Qiao L,Zhou Y,Babiuk LA,Liu Q

更新日期：2010-11-19 00:00:00

abstract：:Irradiation induces severe damage in the hematopoietic system, which leads to bone marrow hyperplasia, pancytopenia, and aggravated tissue formation in bone marrow. Studies have shown that Toll-like receptor 4 (TLR4) has a protective effect against irradiation, but the underlying mechanism remains unclear. In this stu...

journal_title：Biochemical and biophysical research communications

authors： Sun Z,Wu K,Lin Q,Fei H,Jiang H,Chen T,Yuan Y

更新日期：2019-12-03 00:00:00