当前位置： SCI文献检索 > BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS期刊下所有文献 > Cloning and expression of a cDNA for human cytochrome P-450aldo as related to primary aldosteronism.

Cloning and expression of a cDNA for human cytochrome P-450aldo as related to primary aldosteronism.

Abstract：

:A cDNA clone encoding human aldosterone synthase cytochrome P-450 (P-450aldo) has been isolated from a cDNA library derived from human adrenal tumor of a patient suffering from primary aldosteronism. The insert of the clone contains an open reading frame encoding a protein of 503 amino acid residues together with a 3 bp 5'-untranslated region and a 1424 bp 3'-untranslated region to which a poly(A) tract is attached. The nucleotide sequence of P-450aldo cDNA is 93% identical to that of P-450(11) beta cDNA. Catalytic functions of these two P-450s expressed in COS-7 cells are very similar in that both enzymes catalyze the formation of corticosterone and 18-hydroxy-11-deoxycorticosterone using 11-deoxycorticosterone as a substrate. However, they are distinctly different from each other in that P-450aldo preferentially catalyzes the conversion of 11-deoxycorticosterone to aldosterone via corticosterone and 18-hydroxycorticosterone while P-450(11)beta substantially fails to catalyze the reaction to form aldosterone. These results suggest that P-450aldo is a variant of P-450(11)beta, but this enzyme is a different gene product possibly playing a major role in the synthesis of aldosterone at least in a patient suffering from primary aldosteronism.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Kawainoto T,Mitsuuchi Y,Ohnishi T,Ichikawa Y,Yokoyama Y,Sumimoto H,Toda K,Miyahara K,Kuribayashi I,Nakao K

doi

10.1016/s0006-291x(05)81058-7

subject

Has Abstract,Author List Incomplete

pub_date

1990-11-30 00:00:00

pages

309-16

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(05)81058-7

journal_volume

173

pub_type

杂志文章

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