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Immunohistological detection of BRAF25 in human prostate tumor and cancer specimens.

Abstract：

:BRAF25 is an alternatively spliced protein of BRAF35 (see associated paper). We have mapped the BRAF25 gene to chromosome sub-band 19p13.3, a region where loss of chromosomal heterozygosity has been reported in about 50% of ovarian cancers. Because of the high incidence of genetic links of prostate cancer to breast and ovarian cancers, we investigated the BRAF25 expression in the prostate specimens. Immunohistochemical analysis using antibodies specific for BRAF25 revealed a strong immunostaining in sections of the benign prostatic hyperplasia (BPH). The staining was concentrated on the nuclei of cells facing the lumen of prostatic glands, even though the sporadic nuclei of cells in stromas were also stained. However, the expression of BRAF25 was dramatically reduced in intermediate prostate cancer and absent in advanced prostate cancer. Preincubation of the antibody with the immunizing peptide abolished immunostaining in BPH specimens. Therefore, the expression of BRAF25 was gradually lost in prostate cancer.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Wang C,McCarty IM,Balazs L,Li Y,Steiner MS

doi

10.1016/s0006-291x(02)00625-3

subject

Has Abstract

pub_date

2002-07-05 00:00:00

pages

136-41

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(02)00625-3

journal_volume

295

pub_type

杂志文章

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