Unglycosylated rat alpha 1-proteinase inhibitor has a six-fold shorter plasma half-life than the mature glycoprotein.

abstract：:The presence of cancer stem cells, in both hematopoietic and solid malignancies, has been recently linked to their pathogenesis. We aimed to identify the characteristics and stem-like properties of sphere-colony forming cells in rat osteosarcoma and malignant fibrous histiocytoma cell lines. The results showed that bo...

journal_title：Biochemical and biophysical research communications

authors： Fujii H,Honoki K,Tsujiuchi T,Kido A,Yoshitani K,Mori T,Takakura Y

更新日期：2007-10-26 00:00:00

abstract：:We have determined the ability of two well-characterized eukaryotic homing endonucleases, I-PpoI from the myxomycete Physarum polycephalum and I-CreI from the green alga Chlamydomonas reinhardtii, to generate site-specific DNA double-strand breaks in human cells. These 18-kDa proteins cleave highly conserved 15- or 24...

journal_title：Biochemical and biophysical research communications

authors： Monnat RJ Jr,Hackmann AF,Cantrell MA

更新日期：1999-02-05 00:00:00

abstract：:Previous studies have shown that functionalized gold nanoparticles (AuNPs) can be used as a general platform for loading and delivering DNA oligonucleotides and short hairpin RNA to living systems. Here, we report the ability of functionalized AuNP to deliver RNA aptamers into the nuclei of human cells. An in vitro-sy...

journal_title：Biochemical and biophysical research communications

authors： Ryou SM,Kim JM,Yeom JH,Hyun S,Kim S,Han MS,Kim SW,Bae J,Rhee S,Lee K

更新日期：2011-12-09 00:00:00

abstract：:Nuclei were isolated from bloodstream forms of Trypanosoma brucei by nitrogen cavitation and sedimentation through percoll density gradients. Transcription studies with these nuclei in vitro demonstrated features not seen with other eukaryotes: RNA synthesis was much greater in the presence of Mn2+ than with Mg2+ and ...

journal_title：Biochemical and biophysical research communications

authors： Earnshaw DL,Beebee TJ,Gutteridge WE

更新日期：1985-09-16 00:00:00

abstract：:The effects of selective inhibition of cyclic AMP phosphodiesterase type III on insulin and glucose levels during an oral glucose challenge were evaluated in obese, diabetic ob/ob mice and in lean, non-diabetic littermates using the selective inhibitor, milrinone. Oral administration of milrinone increased plasma insu...

journal_title：Biochemical and biophysical research communications

authors： Parker JC,VanVolkenburg MA,Nardone NA,Hargrove DM,Andrews KM

更新日期：1997-07-30 00:00:00

abstract：:Abnormal perpetual inflammatory response and sequential cytokine-induced prostaglandin E2 (PGE2) play important roles in the pathogenesis of rheumatoid arthritis (RA). The underlying regulatory mechanism, however, remain largely unknown. Here, we discovered that expression level of Metastasis associated protein 1 (MTA...

journal_title：Biochemical and biophysical research communications

authors： Wang H,Dong BW,Zheng ZH,Wu ZB,Li W,Ding J

更新日期：2016-04-29 00:00:00

abstract：:Discoidin domain receptor 2 (DDR2) is a receptor tyrosine kinase that is activated by fibrillar collagens. DDR2 regulates cell proliferation, cell adhesion, migration, and extracellular matrix remodeling. The decrement of endogenous DDR2 represses osteoblastic marker gene expression and osteogenic differentiation in m...

journal_title：Biochemical and biophysical research communications

authors： Kawai I,Hisaki T,Sugiura K,Naito K,Kano K

更新日期：2012-10-26 00:00:00

abstract：:Using the patch-clamp technique, we determined that 1-15 mM extracellular acetylcholine reduced whole-cell n-type K+ currents in human peripheral blood lymphocytes and accelerated their inactivation. The percentage increase in K+ channel inactivation rate and the degree of drug induced block were independent of membra...

journal_title：Biochemical and biophysical research communications

authors： Gáspár R Jr,Varga Z,Bene L,Marcheselli F,Pieri C,Damjanovich S

更新日期：1996-09-13 00:00:00

abstract：:Recent structural investigations on the beta-1,4-galactosyltransferase-1 (Gal-T1) and lactose synthase (LS) have revealed that they are akin to an exquisite mechanical device with two well-coordinated flexible loops that are contained within the Gal-T1 catalytic domain. The smaller one has a Trp residue (Trp314) flank...

journal_title：Biochemical and biophysical research communications

authors： Ramakrishnan B,Boeggeman E,Qasba PK

更新日期：2002-03-15 00:00:00

abstract：:The filamentous fungus Aspergillus fumigatus is the major cause of life threatening invasive aspergillosis, and its small hydrophobic asexual spores (conidia) are the major infection agent. To better understand biology of A. fumigatus, we have characterized the rax1 gene encoding a putative regulator of G protein sign...

journal_title：Biochemical and biophysical research communications

authors： Igbalajobi OA,Yu JH,Shin KS

更新日期：2017-05-27 00:00:00

abstract：:The domain(s) responsible for the specific heterophilic adhesion between two members of the carcinoembryonic antigen (CEA) family, CEACAM6 and CEACAM8, both of which with three extracellular domains, were investigated using Chinese hamster ovary (CHO) transfectants expressing chimeric antigens. Using a chimeric antige...

journal_title：Biochemical and biophysical research communications

authors： Oikawa S,Sugiyama M,Kuroki M,Kuroki M,Nakazato H

更新日期：2000-11-30 00:00:00

abstract：:Oxidative stress induced vascular endothelial cell injure is one of the key and initial event in the development of atherosclerosis. Septin4, as a member of GTP binding protein family, is widely expressed in the eukaryotic cells and considered to be an essential component of the cytoskeleton which is involved in many ...

journal_title：Biochemical and biophysical research communications

authors： Zhang N,Zhang Y,Zhao S,Sun Y

更新日期：2018-02-05 00:00:00

abstract：:The octaheme cytochrome c3 (Mr 26000) from Desulfovibrio desulfuricans Norway was studied using cyclic voltammetry at the pyrolytic graphite electrode. The kinetics of reduction of the octaheme cytochrome c3 (Mr 26000) from D. desulfuricans Norway by the Ni-Fe-Se hydrogenase purified from the same organism was investi...

journal_title：Biochemical and biophysical research communications

authors： Haladjian J,Bianco P,Guerlesquin F,Bruschi M

更新日期：1991-08-30 00:00:00

abstract：:This study was undertaken to interrogate cancer cell survival during long-term hypoxic stress. Two systems with relevance to carcinogenesis were employed: Fully transformed BJ cells and a renal carcinoma cell line (786-0). The dynamic of AMPK activity was consistent with a prosurvival role during chronic hypoxia. This...

journal_title：Biochemical and biophysical research communications

authors： Borger DR,Gavrilescu LC,Bucur MC,Ivan M,Decaprio JA

更新日期：2008-05-30 00:00:00

abstract：:Hypothetical lambda protein ORF314 shows significant homology with the carboxyl end of phage T4 tail-fiber protein gp37. Homology can also be demonstrated between hypothetical lambda protein ORF194 and a fragment of bacteriophage T4 protein gp38. This sequence homology is also reflected in the genomic sequences of the...

journal_title：Biochemical and biophysical research communications

authors： George DG,Yeh LS,Barker WC

更新日期：1983-09-30 00:00:00

abstract：:Hypothermia followed by slow rewarming is neuroprotective for ischemic stroke. However, slow rewarming causes patients' longer stay in intensive care unit and increases the risk of hypothermic complications. Hypothermia followed by rapid rewarming (HTRR) is more convenient; but it exacerbates intracranial hypertension...

journal_title：Biochemical and biophysical research communications

authors： Zhu SZ,Gu Y,Wu Z,Hu YF,Pan SY

更新日期：2016-05-20 00:00:00

abstract：:The calcium-sensing receptor (CaSR) was cloned initially from the bovine parathyroid and its primary physiological role is maintaining constant blood Ca(2+) levels. Subsequently, CaSR was found to be expressed in human adipose tissue, however, its physiological functions remain unclear. In this study, the effect of Ca...

journal_title：Biochemical and biophysical research communications

authors： He Y,Zhang H,Teng J,Huang L,Li Y,Sun C

更新日期：2011-01-07 00:00:00

abstract：:Skinned muscle fibers prepared from fetal rabbit heart (28 days of gestation) showed a marked resistance to acidic pH in the Ca(2+) regulation of force generation, compared to the fibers prepared from adult heart. SDS-PAGE and immunoblot analysis showed that the slow skeletal troponin I was predominantly expressed in ...

journal_title：Biochemical and biophysical research communications

authors： Morimoto S,Goto T

更新日期：2000-01-27 00:00:00

abstract：AIMS:New Zealand obese (NZO) mice exhibit a polygenic syndrome of obesity, insulin resistance, and hypercholesterolemia that resembles the human metabolic syndrome. This study was performed in order to locate genes responsible for elevated serum cholesterol and to compare their effects under a standard and high fat die...

journal_title：Biochemical and biophysical research communications

authors： Giesen K,Plum L,Kluge R,Ortlepp J,Joost HG

更新日期：2003-05-16 00:00:00

abstract：:Cell cultures of neonatal rat cerebral cortex in a serum-free medium were used to investigate a lack of neuronotrophic factors in Alzheimer's disease (AD) brain. A few neurons survived in the absence of brain extract. The addition of normal brain extract resulted in a 2.5-fold increase in neuronal survival. AD brain e...

journal_title：Biochemical and biophysical research communications

authors： Uchida Y,Ihara Y,Tomonaga M

更新日期：1988-02-15 00:00:00

abstract：:S-Nitrosylation emerges as an important protein modification in many processes. However, most data were obtained at the protein level after addition of a NO donor, particularly in plants where information about the cysteines nitrosylated in these proteins is scarce. An adapted work-flow, combining the classical biotin...

journal_title：Biochemical and biophysical research communications

authors： Fares A,Rossignol M,Peltier JB

更新日期：2011-12-16 00:00:00

abstract：:Although chronic voluntary physical activity has been shown to enhance hippocampal brain-derived neurotrophic factor (BDNF) expression in animals, the effects of forced exercise on a treadmill have not been fully investigated. We assessed induction of c-fos and BDNF expression with acute exercise at different running ...

journal_title：Biochemical and biophysical research communications

authors： Soya H,Nakamura T,Deocaris CC,Kimpara A,Iimura M,Fujikawa T,Chang H,McEwen BS,Nishijima T

更新日期：2007-07-13 00:00:00

abstract：:Rhodamine 123, a laser dye, has been demonstrated to inhibit import of the precursor to pyridine dinucleotide transhydrogenase into mitochondria in rat liver cells. When rat hepatocytes were labeled with 35[S] methionine in the presence of 0.4 mM rhodamine 123, the precursor to transhydrogenase was found to have a hal...

journal_title：Biochemical and biophysical research communications

authors： Lubin IM,Wu LN,Wuthier RE,Fisher RR

更新日期：1987-04-14 00:00:00

abstract：:Oxidative stress plays an important role in the development of diabetic retinopathy. Here, we examined whether α-lipoic acid (α-LA), a natural antioxidant, attenuated retinal injury in diabetic mice. The α-LA was orally administered to control mice or mice with streptozotocin-induced diabetes. We found that α-LA reduc...

journal_title：Biochemical and biophysical research communications

authors： Kim YS,Kim M,Choi MY,Lee DH,Roh GS,Kim HJ,Kang SS,Cho GJ,Hong EK,Choi WS

更新日期：2018-09-10 00:00:00

abstract：:A radioactive photoaffinity probe for the insulin receptor was prepared by derivatizing insulin at its B29 lysine with a novel crosslinking reagent having a cleavable azo linkage. Insulin receptors purified from human placental membranes were photoaffinity labeled with this probe. The photolabeled receptor was treated...

journal_title：Biochemical and biophysical research communications

authors： Ng DS,Yip CC

更新日期：1985-11-27 00:00:00

abstract：:When treated with T3, P19 cells differentiate into ultrastructurally proven cardiac myocytes and express the cardiac ventricular specific marker ventricular myosin light chain 2V. This differentiation is irreversibly induced in culture during the first 48 hrs of exposure to T3. We studied the binding of P19-indigenous...

journal_title：Biochemical and biophysical research communications

authors： Rodriguez ER,Tan CD,Onwuta US,Parrillo JE

更新日期：1994-12-30 00:00:00

abstract：:5'-RACE and genomic cloning were used to determine that the mouse TBP (mTBP) gene consists of one 5'-terminal non-coding exon followed by seven protein-coding exons. The region upstream of the first exon lacks a TATA-box. Hence, as with the case of other genes carrying TATA-less promoter, transcription starts from a c...

journal_title：Biochemical and biophysical research communications

authors： Ohbayashi T,Schmidt EE,Makino Y,Kishimoto T,Nabeshima Y,Muramatsu M,Tamura T

更新日期：1996-08-05 00:00:00

abstract：:Trilobolide and 2,5-di(tert-butyl)-1,4-benzohydroquinone (BHQ) are potent inhibitors of the Ca(2+)-ATPase of skeletal muscle sarcoplasmic reticulum. Desoxytrilobolide and 2,5-di(tert-butyl)-1,4-diacetylphenol (acetyl-BHQ) have much lower potencies than their parent compounds and 2,5-di(tert-butyl)-1,4-benzoquinone (BQ...

journal_title：Biochemical and biophysical research communications

authors： Wictome M,Holub M,East JM,Lee AG

更新日期：1994-03-15 00:00:00

abstract：OBJECT:The wall thickness of intracranial aneurysms (IAs) is heterogeneous. Although thinning of the IA wall is thought to contribute to IA rupture, the underlying mechanism remains poorly understood. Recently, imaging mass spectroscopy (IMS) has been used to reveal the distribution of phospholipids in vascular disease...

journal_title：Biochemical and biophysical research communications

authors： Ikedo T,Minami M,Kataoka H,Hayashi K,Nagata M,Fujikawa R,Yamazaki F,Setou M,Yokode M,Miyamoto S

更新日期：2018-01-01 00:00:00

abstract：:There is a close linear correlation between the log partition coefficient (Pa) of a series of 2'-deoxyriboside (dR), 2',3'-didehydro-3'-dideoxyriboside (ddeR), 2',3'-dideoxyriboside (ddR), 3'-fluoro-2',3'-dideoxyriboside (FddR) and 3'-azido-2',3'-dideoxyriboside (AzddR) derivatives of uracil, cytosine, thymine, guanin...

journal_title：Biochemical and biophysical research communications

authors： Balzarini J,Cools M,De Clercq E

更新日期：1989-01-31 00:00:00