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Involvement of calcium-sensing receptor in inhibition of lipolysis through intracellular cAMP and calcium pathways in human adipocytes.

Abstract：

:The calcium-sensing receptor (CaSR) was cloned initially from the bovine parathyroid and its primary physiological role is maintaining constant blood Ca(2+) levels. Subsequently, CaSR was found to be expressed in human adipose tissue, however, its physiological functions remain unclear. In this study, the effect of CaSR on lipolysis and the mechanisms by which it functions were explored in SW872 cells. The results showed an inhibitory effect of CaSR on lipolysis after its being activated by GdCl(3), a CaSR agonist. CaSR stimulation decreased both cyclic AMP (cAMP) level and cAMP-dependent protein kinase A (PKA) activity. GdCl(3) treatment led to an increase in intracellular calcium ([Ca(2+)](i)) and mRNA level of phosphodiesterase3B (PDE3B). Furthermore, the downstream key enzymes of lipolysis, HSL and ATGL, were downregulated at both the transcription and translation levels by treatment with GdCl(3). Compared to the control group, the above effects were prevented by either NPS2390, a CaSR antagonist, or CaSR gene silencing by small interfering RNA (siRNA). These findings suggest that CaSR plays an antilipolytic role by mediating potential [Ca(2+)](i) and cAMP pathways and resultant downregulation of lipolysis key enzymes in adipocytes.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

He Y,Zhang H,Teng J,Huang L,Li Y,Sun C

doi

10.1016/j.bbrc.2010.11.129

subject

Has Abstract

pub_date

2011-01-07 00:00:00

pages

393-9

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(10)02204-7

journal_volume

404

pub_type

杂志文章

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