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Wnt3 and Gata4 regulate axon regeneration in adult mouse DRG neurons.

Abstract：

:Neurons in the adult central nervous system (CNS) have a poor intrinsic axon growth potential after injury, but the underlying mechanisms are largely unknown. Wingless-related mouse mammary tumor virus integration site (WNT) family members regulate neural stem cell proliferation, axon tract and forebrain development in the nervous system. Here we report that Wnt3 is an important modulator of axon regeneration. Downregulation or overexpression of Wnt3 in adult dorsal root ganglion (DRG) neurons enhances or inhibits their axon regeneration ability respectively in vitro and in vivo. Especially, we show that Wnt3 modulates axon regeneration by repressing mRNA translation of the important transcription factor Gata4 via binding to the three prime untranslated region (3'UTR). Downregulation of Gata4 could restore the phenotype exhibited by Wnt3 downregulation in DRG neurons. Taken together, these data indicate that Wnt3 is a key intrinsic regulator of axon growth ability of the nervous system.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Duan RS,Liu PP,Xi F,Wang WH,Tang GB,Wang RY,Saijilafu,Liu CM

doi

10.1016/j.bbrc.2018.03.138

subject

Has Abstract

pub_date

2018-05-05 00:00:00

pages

246-252

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(18)30636-3

journal_volume

499

pub_type

杂志文章

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