Mechanism of estrogen action on cellular proliferation: evidence for indirect and negative control on cloned breast tumor cells.

abstract：:We previously showed that beta-defensin-1 (BD-1), an anti-microbial peptide, is up-regulated during progressive hyperglycemia in the kidneys of the GK rat [R.A. Page, C.A. Morris, J.D. Williams, C.J. von Ruhland, A.N. Malik, Isolation of diabetes-associated kidney genes using differential display, Biochem. Biophys. Re...

journal_title：Biochemical and biophysical research communications

authors： Malik AN,Al-Kafaji G

更新日期：2007-02-09 00:00:00

abstract：:p53 mutations are mostly single amino acid changes resulting in expression of a stable mutant protein with "gain of function" (GOF) activity having a dominant oncogenic role rather than simple loss of function of wild-type p53. Knock-down of mutant p53 in human lung cancer cell lines with different endogenous p53 muta...

journal_title：Biochemical and biophysical research communications

authors： Vaughan CA,Frum R,Pearsall I,Singh S,Windle B,Yeudall A,Deb SP,Deb S

更新日期：2012-11-09 00:00:00

abstract：:p47-phox is one of the cytosolic activation factors of NADPH oxidase in neutrophils and known to translocate to plasma membranes and function by protein kinase C-phosphorylation. In cytosol fraction, prepared from calyculin A-treated neutrophils, the activity of cytosolic factor to activate NADPH oxidase was more redu...

journal_title：Biochemical and biophysical research communications

authors： Yamaguchi M,Saeki S,Yamane H,Okamura N,Ishibashi S

更新日期：1995-11-02 00:00:00

abstract：:Myeloid differentiation protein 2 (MD-2) is a co-receptor of toll-like receptor 4 (TLR4) for innate immunity. Here, we delineated a new mechanism of 1-dehydro-10-gingerdione (1D10G), one of pungent isolates from ginger (Zingiber officinale), in the suppression of lipopolysaccharide (LPS)-induced gene expression of inf...

journal_title：Biochemical and biophysical research communications

authors： Park SH,Kyeong MS,Hwang Y,Ryu SY,Han SB,Kim Y

更新日期：2012-03-23 00:00:00

abstract：:Leucine-rich repeat kinase 2 (LRRK2) is the causal gene for autosomal dominant familial Parkinson's disease. We have previously reported a novel molecular feature characteristic to I2020T mutant LRRK2: higher susceptibility to post-translational degradation than the wild-type LRRK2. In the present study, we demonstrat...

journal_title：Biochemical and biophysical research communications

authors： Ohta E,Kubo M,Obata F

更新日期：2010-01-01 00:00:00

abstract：:It has been proposed that the members of the hsp70 major heat shock protein family in non-stressed cells participate in the intracellular transport of newly synthesized proteins and in maintaining such proteins in an unfolded state. Specific binding of other cellular proteins to hsp70 may play a role in hsp70 function...

journal_title：Biochemical and biophysical research communications

authors： Margulis BA,Welsh M

更新日期：1991-07-15 00:00:00

abstract：:The metalated forms of metallothionein are well studied (particularly Zn-MT, Cu-MT and Cd-MT), but almost nothing is known about the chemical and structural properties of apometallothioneins despite their importance in initial metalation and subsequent demetalation. Electrospray ionization mass spectrometry was used t...

journal_title：Biochemical and biophysical research communications

authors： Summers KL,Mahrok AK,Dryden MD,Stillman MJ

更新日期：2012-08-24 00:00:00

abstract：:Lecithin-cholesterol acyltransferase (LCAT) is responsible for the formation of cholesterol esters in plasma and is implicated in the removal of excess cholesterol from peripheral tissues. It is generally accepted that the catalytic mechanism of LCAT is similar to that of serine proteases and lipases involving a Ser, ...

journal_title：Biochemical and biophysical research communications

authors： Adimoolam S,Lee YP,Jonas A

更新日期：1998-02-13 00:00:00

abstract：:The effect of steroid chemical structure on steroid-lipid interaction is studied in sonicated dipalmitoyl phosphatidylcholine vesicles by steady-state and time-resolved fluorescence anisotropy techniques using diphenylhexatriene as probe. A large number of cholesterol derivatives and steroids, some of them being precu...

journal_title：Biochemical and biophysical research communications

authors： Vincent M,Gallay J

更新日期：1983-06-29 00:00:00

abstract：:States characterised by elevated plasma fatty acid levels are accompanied by increased UCP2 expression but the physiological regulation of UCP2 expression in white adipose tissue is not fully understood. We used 3T3-L1 preadipocytes to determine whether various dietary fatty acids (20:5, 18:3, 18:2, 18:1, 18:0) direct...

journal_title：Biochemical and biophysical research communications

authors： Reilly JM,Thompson MP

更新日期：2000-11-02 00:00:00

abstract：:Emp, originally detected in erythroblastic islands, is expressed in numerous cell types and tissues suggesting a functionality not limited to hematopoiesis. To study the function of Emp in non-hematopoietic cells, an epitope-tagged recombinant human Emp was expressed in HEK cells. Preliminary studies revealed that Emp...

journal_title：Biochemical and biophysical research communications

authors： Bala S,Kumar A,Soni S,Sinha S,Hanspal M

更新日期：2006-04-21 00:00:00

abstract：:The long-sought three-dimensional structure of the M2 proton channel of influenza A virus was successfully determined recently by the high-resolution NMR [J.R. Schnell, J.J. Chou, Structure and mechanism of the M2 proton channel of influenza A virus, Nature 451 (2008) 591-595]. Such a milestone work has provided a sol...

journal_title：Biochemical and biophysical research communications

authors： Huang RB,Du QS,Wang CH,Chou KC

更新日期：2008-12-26 00:00:00

abstract：:The ability of the rat brain to activate the phosphorothionate insecticide parathion to its potent anticholinesterase metabolite paraoxon in situ was observed by ligating the posterior portion of the circulatory system and thus removing the liver from the circulation. Under these conditions no acetylcholinesterase inh...

journal_title：Biochemical and biophysical research communications

authors： Chambers JE,Munson JR,Chambers HW

更新日期：1989-11-30 00:00:00

abstract：:We have established that differing effects of alpha1-adrenergic receptor (AR) subtypes on cell proliferation are due to differential coupling to the Gs/cAMP pathway; thus, both alpha1A- and alpha1B-ARs couple to Gs, while alpha1D-AR does not. To identify the region responsible for this difference in subtype-specific G...

journal_title：Biochemical and biophysical research communications

authors： Shinoura H,Shibata K,Hirasawa A,Tanoue A,Hashimoto K,Tsujimoto G

更新日期：2002-11-22 00:00:00

abstract：:1,25(OH)2D3 receptors were studied in whole testes, Sertoli cells, seminiferous tubules, Leydig cells and spermatogonia of adult NMRI mice and SD rats. Specific reversible high affinity binding (KD 1.4 x 10(-10)M; Nmax 72 fmol/mg protein) by a 3.5 S macromolecule was demonstrated in whole testes, Sertoli cells and sem...

journal_title：Biochemical and biophysical research communications

authors： Merke J,Hügel U,Ritz E

更新日期：1985-02-28 00:00:00

abstract：:Enterovirus 71 (EV71) has led to recent outbreaks of hand, foot and mouth disease (HFMD) in China, resulting in high mortality. In this study, several monoclonal antibodies were generated by immunizing mice with two synthetic peptides, SP55 and SP70, containing amino acids 163-177 and 208-222 of VP1. The specificities...

journal_title：Biochemical and biophysical research communications

authors： Li X,Mao C,Ma S,Wang X,Sun Z,Yi Y,Guo M,Shen X,Sun L,Bi S

更新日期：2009-12-25 00:00:00

abstract：:The three-dimensional structure of Bruton's agammaglobulinemia tyrosine kinase (Btk) SH2 domain was modeled based on v-Src. Btk SH2 is presumably very related to the other SH2 structures consisting of two beta-sheets surrounded by two alpha-helices, with a well conserved hydrophobic core and phoshotyrosyl peptide bind...

journal_title：Biochemical and biophysical research communications

authors： Vihinen M,Nilsson L,Smith CI

更新日期：1994-12-15 00:00:00

abstract：:We propose that one manifestation of altered sphingolipid metabolism within tumor cells may be a reduced sensitivity to anti-cancer therapies because of an inability to produce a sufficient apoptotic signal via sphingomyelin hydrolysis to ceramide. If so, then sphingomyelin administration could reverse this effect and...

journal_title：Biochemical and biophysical research communications

authors： Modrak DE,Lew W,Goldenberg DM,Blumenthal R

更新日期：2000-02-16 00:00:00

abstract：:Methylglyoxal (MG) (pyruvaldehyde) is an endogenous metabolite which is present in increased concentrations in diabetics and implicated in formation of advanced glycosylation end-products (AGEs) and secondary diabetic complications. Carnosine (beta-alanyl-L-histidine) is normally present in long-lived tissues at conce...

journal_title：Biochemical and biophysical research communications

authors： Hipkiss AR,Chana H

更新日期：1998-07-09 00:00:00

abstract：:We examined the possibility that bilirubin physiologically acts as an antioxidant by using scurvy-prone ODS-od/od rats treated with endotoxin (lipopolysaccharide: LPS). Recently, bilirubin oxidative metabolites were isolated from human urine and named biotripyrrin-a and biotripyrrin-b. The LPS injection markedly incre...

journal_title：Biochemical and biophysical research communications

authors： Yamaguchi T,Horio F,Hashizume T,Tanaka M,Ikeda S,Kakinuma A,Nakajima H

更新日期：1995-09-05 00:00:00

abstract：:Mast cells play an important role in allergic inflammation by releasing inducible proinflammatory cytokines. While many inducible genes have been identified, we hypothesized that a significant number remain to be identified. We thus constructed an activation-specific mast cell subtraction library to establish a profil...

journal_title：Biochemical and biophysical research communications

authors： Cho JJ,Vliagoftis H,Rumsaeng V,Metcalfe DD,Oh CK

更新日期：1998-01-06 00:00:00

abstract：:A mutant of Photinus pyralis luciferase in which all four native cysteine residues are converted to serines retains about 10% of wild-type activity. This mutant should prove useful as a starting point for the introduction of biophysical probes of conformational changes associated with enzyme function. The activities o...

journal_title：Biochemical and biophysical research communications

authors： Kumita JR,Jain L,Safroneeva E,Woolley GA

更新日期：2000-01-07 00:00:00

abstract：:In hematopoietic cells, Ras has been implicated in signaling pathways that prevent apoptosis triggered by deprivation of cytokines, such as interleukin-3 (IL-3). However, the mechanism whereby Ras suppresses cell death remains incompletely understood. We have investigated the role of Ras in IL-3 signal transduction by...

journal_title：Biochemical and biophysical research communications

authors： Terada K,Kaziro Y,Satoh T

更新日期：2000-01-07 00:00:00

abstract：:Phosgene is a toxic gas that is widely used in modern industry, and its inhalation can cause severe pulmonary edema. There is no effective clinical treatment because the mechanism of phosgene-induced pulmonary edema still remains unclear. Many studies have demonstrated that the Na(+)/K(+)-ATPase plays a critical role ...

journal_title：Biochemical and biophysical research communications

authors： Qin XJ,Li YN,Liang X,Wang P,Hai CX

更新日期：2008-02-29 00:00:00

abstract：:In this study, we attempt to determine whether lycopene regulates inflammatory mediators in the ovalbumin (OVA)-induced murine asthma model. To address this, mice were sensitized and challenged with OVA, and then treated with lycopene before the last OVA challenge. Administration of lycopene significantly alleviated t...

journal_title：Biochemical and biophysical research communications

authors： Lee CM,Chang JH,Moon DO,Choi YH,Choi IW,Park YM,Kim GY

更新日期：2008-09-19 00:00:00

abstract：:The neural system appears before the vascular system in the phylogenetic tree. During evolution, vascular system generation takes advantage of the pre-existing vascular endothelial growth factor (VEGF) in order to form its networks. Nevertheless, the role of VEGF in neuronal and glial cells is not yet completely under...

journal_title：Biochemical and biophysical research communications

authors： Fusco MA,Wajsenzon IJ,de Carvalho SL,da Silva RT,Einicker-Lamas M,Cavalcante LA,Allodi S

更新日期：2014-05-02 00:00:00

abstract：:HNK-1 antibody reactive carbohydrate epitope carried by glycolipids and glycoproteins has been shown to be involved in cell to cell interactions. It has been proposed that the HNK-1 reactive 3-sulfoglucuronyl carbohydrate epitope in glycolipids may interact with a cell surface receptor to promote the biological respon...

journal_title：Biochemical and biophysical research communications

authors： Mohan PS,Laitinen J,Merenmies J,Rauvala H,Jungalwala FB

更新日期：1992-01-31 00:00:00

abstract：:To investigate the role of myotonin-protein kinase (MT-PK) in the pathophysiology of myotonic dystrophy (DM), we developed specific antibodies against synthetic MT-PK peptides. The antibody identified a 53kDa protein in skeletal muscle and recognized decreases in the amount of the protein in both adult and congenital ...

journal_title：Biochemical and biophysical research communications

authors： Koga R,Nakao Y,Kurano Y,Tsukahara T,Nakamura A,Ishiura S,Nonaka I,Arahata K

更新日期：1994-07-15 00:00:00

abstract：:Abnormal lipid metabolism may contribute to the pathogenesis of non-alcoholic steatohepatitis (NASH). The ATP-binding cassette transporter A1 (ABCA1) protein mediates the transport of cholesterol and phospholipids from cells to apolipoprotein A-I (apoA-I) to generate nascent HDL particles. Previous studies revealed th...

journal_title：Biochemical and biophysical research communications

authors： Liang H,Wang Y

更新日期：2018-04-06 00:00:00

abstract：:The polyamines spermidine, spermine and putrescine, by themselves, at physiological concentrations, induce the transport of the precursor of ornithine carbamoyltransferase into isolated rat liver mitochondria. The presence of polyamines in the transport medium results in the approach of both mitochondrial membranes, s...

journal_title：Biochemical and biophysical research communications

authors： Marcote MJ,González-Bosch C,Miralles VJ,Hernández-Yago J,Grisolía S

更新日期：1989-01-16 00:00:00