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Nuclear testicular 1,25-dihydroxyvitamin D3 receptors in Sertoli cells and seminiferous tubules of adult rodents.

Abstract：

:1,25(OH)2D3 receptors were studied in whole testes, Sertoli cells, seminiferous tubules, Leydig cells and spermatogonia of adult NMRI mice and SD rats. Specific reversible high affinity binding (KD 1.4 x 10(-10)M; Nmax 72 fmol/mg protein) by a 3.5 S macromolecule was demonstrated in whole testes, Sertoli cells and seminiferous tubules. With identical techniques, no receptors were found in Leydig cells despite previous reports of 1,25(OH)2D3 actions on Leydig cell function.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Merke J,Hügel U,Ritz E

doi

10.1016/s0006-291x(85)80159-5

subject

Has Abstract

pub_date

1985-02-28 00:00:00

pages

303-9

issue

1

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(85)80159-5

journal_volume

127

pub_type

杂志文章

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