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NOC, a nitric-oxide-releasing compound, induces dose dependent apoptosis in macrophages.

Abstract：

:The ability of exogenous nitric oxide (NO) to induce apoptosis in macrophages was analyzed using NOC, a NO-releasing compound, as a source of NO. Exogenous NO was shown to induce apoptosis in a dose dependent manner. Quantitative analysis revealed that the amount of NO required to induce apoptosis in more than half of macrophages exposed was 100 times larger than that for endogenous NO-induced apoptosis. NOC proved to be a convenient and useful tool for investigation of apoptosis related to NO.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Shimaoka M,Iida T,Ohara A,Taenaka N,Mashimo T,Honda T,Yoshiya I

doi

10.1006/bbrc.1995.1532

subject

Has Abstract

pub_date

1995-04-17 00:00:00

pages

519-26

issue

2

eissn

0006-291X

issn

1090-2104

pii

S0006-291X(85)71532-X

journal_volume

209

pub_type

杂志文章

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