Genistein inhibits activities of methylenetetrahydrofolate reductase and lactate dehydrogenase, enzymes which use NADH as a substrate.

abstract：:GOTO cells, a neuroblastoma cell line retaining the ability to differentiate into neuronal or Schwann cells, were found to be rich in membrane rafts containing ganglioside GM2 and hypersensitive to lipid raft-disrupting methyl-beta-cyclodextrin (MbetaCD); the GM2-rich rafts and sensitivity to MbetaCD were markedly dim...

journal_title：Biochemical and biophysical research communications

authors： Tomioka R,Minami N,Kushida A,Horibe S,Izumi I,Kato A,Fukushima K,Ideo H,Yamashita K,Hirose S,Saito Y

更新日期：2009-11-06 00:00:00

abstract：:The forkhead transcription factor FoxA1 is thought to be involved in mammary tumorigenesis. However, the precise role of FoxA1 in breast cancer development is controversial. We examined expression of FoxA1 in 35 human breast cancer cell lines and compared it with that of ErbB2, a marker of poor prognosis in breast can...

journal_title：Biochemical and biophysical research communications

authors： Yamaguchi N,Ito E,Azuma S,Honma R,Yanagisawa Y,Nishikawa A,Kawamura M,Imai J,Tatsuta K,Inoue J,Semba K,Watanabe S

更新日期：2008-01-25 00:00:00

abstract：:Integrin LFA-1 regulates immune cell adhesion and trafficking by binding to ICAM-1 upon chemokine stimulation. Integrin-mediated clutch formation between extracellular ICAM-1 and the intracellular actin cytoskeleton is important for cell adhesion. We applied single-molecule tracking analysis to LFA-1 and ICAM-1 in liv...

journal_title：Biochemical and biophysical research communications

authors： Ishibashi M,Miyanaga Y,Matsuoka S,Kozuka J,Togashi Y,Kinashi T,Ueda M

更新日期：2015-08-21 00:00:00

abstract：:Cardiac ryanodine receptor gene (RyR2) mutations cause fatal arrhythmogenic diseases such as catecholaminergic polymorphic ventricular tachycardia and arrhythmogenic right ventricular cardiomyopathy. The N-terminal region of RyR2 is one of the hot spots for mutations. In this study, we investigated cardiac phenotypes ...

journal_title：Biochemical and biophysical research communications

authors： Okudaira N,Kuwahara M,Hirata Y,Oku Y,Nishio H

更新日期：2014-09-26 00:00:00

abstract：:The current state of the AD research field is highly dynamic is some respects, while seemingly stagnant in others. Regarding the former, our current lack of understanding of initiating disease mechanisms, the absence of effective treatment options, and the looming escalation of AD patients is energizing new research d...

journal_title：Biochemical and biophysical research communications

authors： Briggs CA,Chakroborty S,Stutzmann GE

更新日期：2017-02-19 00:00:00

abstract：:Atriopeptin (AP) is synthesized and stored in the mammalian atria as a 126 amino acid prohormone (AP126). Upon secretion, the prohormone undergoes site specific proteolysis within the atria to yield the carboxyl terminal 28 amino acid hormone (AP28). The atrial cell responsible for AP126 bioactivation has not yet been...

journal_title：Biochemical and biophysical research communications

authors： Greenwald JE,Needleman P,Siegel N,Tetens E,Biel B,Ritter D

更新日期：1992-10-30 00:00:00

abstract：:Immunochemical and biochemical methods were used to assess quantitatively the changes in the heart creatine kinase system in the myopathic Syrian hamsters, line CHF I46. Cardiomyopathy in I75-200 day old animals was characterized by decreased content of mitochondria and lower total creatine kinase activity. In isolate...

journal_title：Biochemical and biophysical research communications

authors： Khuchua ZA,Ventura-Clapier R,Kuznetsov AV,Grishin MN,Saks VA

更新日期：1989-12-15 00:00:00

abstract：:This study examined whether oral administration of an arginase inhibitor regulates adipose tissue macrophage infiltration and inflammation in mice with high fat diet (HFD)-induced obesity. Male C57BL/6 mice (n = 30) were randomly assigned to control (CTL, n = 10), HFD only (n = 10), and HFD with arginase inhibitor N(ω...

journal_title：Biochemical and biophysical research communications

authors： Hu H,Moon J,Chung JH,Kim OY,Yu R,Shin MJ

更新日期：2015-08-28 00:00:00

abstract：:The role of alcohol consumption and alcoholism as an addiction in regulating the chemistry of the brain and its physiology has gained a backlog of interest over the past few decades. Besides the notion that alcohol acts as a brain depressant, the molecular mechanisms and neuronal interactions are not well understood. ...

journal_title：Biochemical and biophysical research communications

authors： Haddad JJ

更新日期：2004-10-15 00:00:00

abstract：:The Ca(2+)-binding S100A1 protein displays a specific and high expression level in the human myocardium and is considered to be an important regulator of heart contractility. Diminished protein levels detected in dilated cardiomyopathy possibly contribute to impaired Ca(2+) handling and contractility in heart failure....

journal_title：Biochemical and biophysical research communications

authors： Kiewitz R,Acklin C,Schäfer BW,Maco B,Uhrík B,Wuytack F,Erne P,Heizmann CW

更新日期：2003-06-27 00:00:00

abstract：:Primary rat hippocampal neurones show pronounced elevations of intracellular calcium within minutes of exposure to the HIV coat protein gp120. Culture of hippocampal neurones with gp120 causes significant neurotoxicity. We find that the peptide VSLSYRCPCRFF, a competitive inhibitor of the CXCR4 chemokine receptor, mar...

journal_title：Biochemical and biophysical research communications

authors： Pandey V,Bolsover SR

更新日期：2000-07-21 00:00:00

abstract：:Oxidative stress contributes to tissue injury and cell death during the development of various diseases. The present study aims at investigating whether oxidative stress triggered by the exposure to hydrogen peroxide (H(2)O(2)) can induce apoptosis of induced pluripotent stem cells (iPS cells) in a mechanism mediated ...

journal_title：Biochemical and biophysical research communications

authors： Li Y,Shelat H,Geng YJ

更新日期：2012-10-05 00:00:00

abstract：:RNA polymerase II carboxyl-terminal domain (pol II CTD) phosphatases that can dephosphorylate both Ser2-PO(4) and Ser5-PO(4) of CTD have been identified in animals and yeasts, however, only Ser5-PO(4)-specific CTD phosphatases have been identified in plants. Among predicted Arabidopsis SCP1-like small phosphatases (SS...

journal_title：Biochemical and biophysical research communications

authors： Feng Y,Kang JS,Kim S,Yun DJ,Lee SY,Bahk JD,Koiwa H

更新日期：2010-06-25 00:00:00

abstract：:Four clonal cell lines subcloned from a clonal population of fetal rat calvaria cells show a loss of type I collagen synthesis. Northern blot analysis showed that the level of alpha 1(I) collagen mRNA expression in each of the clonal populations parallels the level of collagen protein expression in each of these cell ...

journal_title：Biochemical and biophysical research communications

authors： Waye MM,Robinson R,Orfanides AG,Aubin JE

更新日期：1989-08-15 00:00:00

abstract：:Max binding protein (MNT) is a member of the Myc/Max/Mad network that plays a role in cell proliferation, differentiation and apoptosis. We previously observed that MNT was differentially expressed in hepatocellular carcinoma (HCC) and interacted with Nck1 by 2-DE. Nck family adaptor proteins function to couple tyrosi...

journal_title：Biochemical and biophysical research communications

authors： Wu J,Zhou Q,Wang Y,Zhou X,Li J

更新日期：2012-02-03 00:00:00

abstract：:Through the proteomic analysis using 2-dimensional electrophoresis, the nicotine addiction-associated proteins were extensively screened in the striatum of rat brains. The nicotine addiction was developed by repeated nicotine injection (0.4mg/kg s.c.), twice daily for 7 days, followed by one challenge injection after ...

journal_title：Biochemical and biophysical research communications

authors： Yeom M,Shim I,Lee HJ,Hahm DH

更新日期：2005-01-14 00:00:00

abstract：:Identification of TNF alpha receptors and their regulation by the endocrine system were examined in testicular Sertoli cells. By using cross-linking experiments as well as northern blotting analysis, we detected the p55 receptor type (MW: 55 kDa, mRNA: 2.3 kb), but not the p75 TNF alpha receptor type. Furthermore, we ...

journal_title：Biochemical and biophysical research communications

authors： Mauduit C,Besset V,Caussanel V,Benahmed M

更新日期：1996-07-25 00:00:00

abstract：:Reoxidation of the reduced insulin A and B chains in 8 M urea leads to a recovery of native insulin of 2-7% whereas in 6 M guanidine or 0.5 mM dodecylsulfate very little, if any, resynthesis of insulin could be detected. Considering all the possibilities of different oligomeric forms containing one or both of the chai...

journal_title：Biochemical and biophysical research communications

authors： Qian YQ,Tsou CL

更新日期：1987-07-31 00:00:00

abstract：:Pathological cardiac hypertrophy, often accompanied by hypertension, aortic stenosis and valvular defects, is typically associated with myocyte remodeling and cardiac dysfunction. Exercise preconditioning (EP) has been proven to enhance the tolerance of the myocardium to cardiac ischemia-reperfusion injury. However, t...

journal_title：Biochemical and biophysical research communications

authors： Xu T,Zhang B,Yang F,Cai C,Wang G,Han Q,Zou L

更新日期：2015-05-08 00:00:00

abstract：:Behcet's disease (BD) is a chronic relapsing inflammatory autoimmune disease characterized by recurrent oral and genital ulcers, skin legions and uveitis and its pathogenesis is not fully elucidated. Previously we identified that two novel susceptible SNPs are associated with BD. One is located in putative RNF39 promo...

journal_title：Biochemical and biophysical research communications

authors： Kurata R,Tajima A,Yonezawa T,Inoko H

更新日期：2013-06-21 00:00:00

abstract：:Hepatitis B, a major public health concern worldwide, is caused by hepatitis type B virus, a hepdnavirus that infects only human and certain nonhuman primates, and replicates strictly in hepatocytes. By using the techniques of slot and Southern blot DNA hybridization, and electron microscopy, the presence of HBV was i...

journal_title：Biochemical and biophysical research communications

authors： Pao CC,Wu SY,Hung IJ,Ng KT,Liaw YF,Lo SJ

更新日期：1987-07-31 00:00:00

abstract：:Lipoprotein lipase (LPL) catalyzes the hydrolysis of the triacylglycerol component of triacylglycerol-rich lipoproteins. There are 4 cysteine pairs that are completely conserved among LPLs of all species known. We examined the functional importance of each of the cysteine pairs in enzyme catalysis by examining LPLs pr...

journal_title：Biochemical and biophysical research communications

authors： Lo JY,Smith LC,Chan L

更新日期：1995-01-05 00:00:00

abstract：:With age human collagen demonstrates, amongst other changes, reductions in solubility, elasticity and permeability. Many of these changes have been attributed to non-enzymic glycosylation (glycation)-a spontaneous addition of sugar molecules to any protein with free amino groups. The resulting formation and accumulati...

journal_title：Biochemical and biophysical research communications

authors： Malik NS,Meek KM

更新日期：1994-03-15 00:00:00

abstract：:The metabolites of inflammatory cells produced by massive infection of the peritoneal cavity of two related European species of frogs, Rana temporaria and Rana arvalis were examined for lipoxygenase-generated products of exogenous arachidonic acid. Cells of Rana temporaria produced large amounts of 5-hydroxyeicosatetr...

journal_title：Biochemical and biophysical research communications

authors： Green FA,Herman CA,Herman RP,Claesson HE,Hamberg M

更新日期：1987-01-30 00:00:00

abstract：:Carbon monoxide (CO) and nitric oxide (NO) are two gas molecules which have cytoprotective functions against oxidative stress and inflammatory responses in many cell types. Currently, it is known that NO produced by nitric oxide synthase (NOS) induces heme oxygenase 1 (HO1) expression and CO produced by the HO1 inhibi...

journal_title：Biochemical and biophysical research communications

authors： Lee BS,Heo J,Kim YM,Shim SM,Pae HO,Kim YM,Chung HT

更新日期：2006-05-12 00:00:00

abstract：:Antiserum prepared against the denatured form of mammalian malate dehydrogenase was found to immunoprecipitate the denatured but not the native form of the mature enzyme. In contrast, the antiserum immunoprecipitated the enzyme's precursor, synthesized in a rabbit reticulocyte lysate, either before or after denaturati...

journal_title：Biochemical and biophysical research communications

authors： Chien SM,Freeman KB

更新日期：1986-11-26 00:00:00

abstract：:SMCX/JARID1C was recently shown to be a histone H3 lysine 4 (H3K4) demethylase. Here, we have identified an SMCX isoform that predominantly resides in the cytoplasm, but still efficiently demethylates trimethylated H3K4. SMCX requires several functional domains for its demethylase activity and is also capable of formi...

journal_title：Biochemical and biophysical research communications

authors： Kim TD,Shin S,Janknecht R

更新日期：2008-02-08 00:00:00

abstract：:In this study, the effects of acetylsalicylic acid (aspirin) on the expression of uPAR and the mechanism by which it regulates expression of uPAR was examined in two different colon cancer cell lines HCT116 and GEO, respectively. The study shows that under physiological concentration, aspirin upregulates steady-state ...

journal_title：Biochemical and biophysical research communications

authors： Jamaluddin MS

更新日期：2006-09-22 00:00:00

abstract：:Some properties of calmodulin(CaM)-binding proteins (CaMBPs) of the Ca(2+)-independent type were investigated in the synaptosomal membrane (SM) from rat brain using the [125I]CaM gel overlay method. When SM was prepared in the presence of Ca2+, Ca(2+)-independent CaM binding was decreased, whereas the Ca(2+)-dependent...

journal_title：Biochemical and biophysical research communications

authors： Natsukari N,Miwa A,Fujita M

更新日期：1992-03-16 00:00:00

abstract：:Sinusoidal endothelial cells proliferate following hepatocyte regeneration in the liver after partial resection. The expressions of vascular endothelial growth factor (VEGF) and its receptors, flt-1 and KDR/flk-1, were studied by Northern blotting in isolated rat liver cells and 70% resected rat liver. VEGF was expres...

journal_title：Biochemical and biophysical research communications

authors： Mochida S,Ishikawa K,Inao M,Shibuya M,Fujiwara K

更新日期：1996-09-04 00:00:00