Ca2+ -dependent interaction of S100A1 with the sarcoplasmic reticulum Ca2+ -ATPase2a and phospholamban in the human heart.

abstract：:Heparin binding neurite-promoting factor (HBNF) is a highly basic 136 amino acid protein containing 10 cysteine residues. We have determined the redox status and the disulfide arrangement of the cysteine residues in HBNF from bovine brain and refolded human recombinant protein produced in E. coli. Our data indicate th...

journal_title：Biochemical and biophysical research communications

authors： Hulmes JD,Seddon AP,Decker MM,Böhlen P

更新日期：1993-04-30 00:00:00

abstract：:Indo-1 is widely used to measure intracellular free calcium, [Ca2+]i, by comparing the fluorescence emission at 2 or more wavelengths with the emissions, which are assumed to be known, of Indo-1 when it is fully calcium-bound and when it is fully calcium-free. Accurate quantitation requires that these "reference" valu...

journal_title：Biochemical and biophysical research communications

authors： Owen CS,Shuler RL

更新日期：1989-08-30 00:00:00

abstract：:Human Protein tyrosine kinase 6 (PTK6)(EC:2.7.10.2), also known as the breast tumor kinase (BRK), is an intracellular non-receptor Src-related tyrosine kinase expressed five-fold or more in human breast tumors and breast cancer cell lines but its expression being low or completely absent from normal mammary gland. The...

journal_title：Biochemical and biophysical research communications

authors： Thakur MK,Birudukota S,Swaminathan S,Battula SK,Vadivelu S,Tyagi R,Gosu R

更新日期：2017-01-22 00:00:00

abstract：:We examined the expression of a Caenorhabditis elegans (C. elegans) elav-like gene, which we designated elr-1. The elr-1 gene encodes a predicted 456-amino-acid protein containing three putative RNA-binding domains and belongs to the ELAV family, which is functionally involved in neuronal differentiation. Northern blo...

journal_title：Biochemical and biophysical research communications

authors： Fujita M,Kawano T,Ohta A,Sakamoto H

更新日期：1999-07-14 00:00:00

abstract：:Mitogen-activated protein kinases (MPKs) are involved in a number of signaling pathways that control plant development and stress tolerance via the phosphorylation of target molecules. However, so far only a limited number of target molecules have been identified. Here, we provide evidence that MYB41 represents a new ...

journal_title：Biochemical and biophysical research communications

authors： Hoang MH,Nguyen XC,Lee K,Kwon YS,Pham HT,Park HC,Yun DJ,Lim CO,Chung WS

更新日期：2012-05-25 00:00:00

abstract：:Temozolomide (TMZ) is a methylating agent used in chemotherapy against glioblastoma. This work was designed to clarify details in repair pathways acting to remove DNA double-strand breaks (DSBs) induced by TMZ. Cultured mouse embryonic fibroblasts were used which were deficient in DSB repair genes such as homologous r...

journal_title：Biochemical and biophysical research communications

authors： Kondo N,Takahashi A,Mori E,Ohnishi K,McKinnon PJ,Sakaki T,Nakase H,Ohnishi T

更新日期：2009-10-02 00:00:00

abstract：:Isolated motor endplates from mouse intercostal muscles can be obtained after subcellular fractionation. On these motor endplates, localization of the nicotinic receptor and of the voltage-dependent Na+ channel coincides as demonstrated by double labeling with rhodamine alpha-bungarotoxin and a specific anti-Na+ chann...

journal_title：Biochemical and biophysical research communications

authors： Dreyfus P,Rieger F,Murawsky M,Garcia L,Lombet A,Fosset M,Pauron D,Barhanin J,Lazdunski M

更新日期：1986-08-29 00:00:00

abstract：:Cigarette smoke is a major cause of chronic obstructive pulmonary disease (COPD). Circular RNAs (circRNAs) are involved in regulating various biological processes. This study aimed to explore the role and molecular basis of hsa_circ_0006872 in cigarette smoke extract (CSE)-induced cell injury. HPMECs and BEAS-2B cells...

journal_title：Biochemical and biophysical research communications

authors： Xue M,Peng N,Zhu X,Zhang H

更新日期：2021-01-01 00:00:00

abstract：:Pyrrolidine dithiocarbamate (PDTC) is a synthetic antioxidant molecule, which has been recently proposed as an antitumoral agent on the basis of its capability of inducing apoptosis. We investigated the effect of PDTC on the proliferation and survival of the promyelocitic cell line HL-60. Concentration as low as 10 mi...

journal_title：Biochemical and biophysical research communications

authors： Della Ragione F,Cucciolla V,Borriello A,Della Pietra V,Manna C,Galletti P,Zappia V

更新日期：2000-02-24 00:00:00

abstract：:A cDNA containing the entire coding sequence for the subunit protein of rat liver class theta glutathione S-transferase (GST) Yrs-Yrs was isolated from a rat liver lambda gt11 cDNA library. The cDNA, designated GST theta-1, consisted of 1,258 bp which had an open reading frame of 732 bp encoding a polypeptide of 244 a...

journal_title：Biochemical and biophysical research communications

authors： Ogura K,Nishiyama T,Okada T,Kajital J,Narihata H,Watabe T,Hiratsuka A,Watabe T

更新日期：1991-12-31 00:00:00

abstract：:Rap1GAP (for Rap1 GTPase Activating Protein) is an 89 kD protein that highly stimulates the intrinsic GTPase activity of the small GTP binding protein Rap1. It has been shown that Rap1GAP is phosphorylated in vitro by purified p34cdc2 kinase, which regulates the G2/M transition of the cell cycle. In this work, we have...

journal_title：Biochemical and biophysical research communications

authors： Janoueix-Lerosey I,Fontenay M,Tobelem G,Tavitian A,Polakis P,de Gunzburg J

更新日期：1994-07-29 00:00:00

abstract：:During the search for ANP receptor ligands of microbial origin, we isolated a novel polysaccharide, HS-142-1, from culture broth of Aureobasidium sp. HS-142-1 inhibited [125I]-rANP binding to ANP receptor in rabbit kidney cortex membranes with an IC50 of 0.3 mu g/ml, but gave no effects on specific binding of [125I]-E...

journal_title：Biochemical and biophysical research communications

authors： Morishita Y,Sano T,Ando K,Saitoh Y,Kase H,Yamada K,Matsuda Y

更新日期：1991-05-15 00:00:00

abstract：:DNA cleavage by N-(O,O-diisopropyl)phosphoryl histidine(DIPP-His) is investigated by a submarine agarose electrophoresis technique. It was found that DIPP-His could cleave supercoiled DNAs and lambda DNA without the participation of divalent metal ions, while the histidine itself and N-(O,O-diisopropyl)phosphoryl alan...

journal_title：Biochemical and biophysical research communications

authors： Li Y,Sha YW,Ma Y,Zhao Y

更新日期：1995-08-24 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by the deposition of β-amyloid (Aβ) peptide in the brain, which is produced by the proteolysis of β-amyloid precursor protein (APP). Recently, the mitochondrial transcription factor 4 (MTERF4), a member of the MTERF family, was implicated in regulating mitochondrial DNA transc...

journal_title：Biochemical and biophysical research communications

authors： Wang XL,Liu Q,Chen GJ,Li ML,Ding YH

更新日期：2017-01-22 00:00:00

abstract：:The placenta releases syncytiotrophoblast-derived extracellular vesicles (STB-EV) into the maternal circulation throughout gestation. STB-EV dependent signalling is believed to contribute to the widespread maternal adaptive physiological changes seen in pregnancy. Transfer RNA (tRNA) halves have been identified in ves...

journal_title：Biochemical and biophysical research communications

authors： Cooke WR,Cribbs A,Zhang W,Kandzija N,Motta-Mejia C,Dombi E,Ri R,Cerdeira AS,Redman C,Vatish M

更新日期：2019-10-08 00:00:00

abstract：:Lipopolysaccharide (LPS)-induced multiple organ injury was mediated in part by a transcription factor, nuclear factor-kappaB (NF-kappaB). Mice were pretreated with dexamethasone (DEX), an inhibitor of NF-kappaB activation, to elucidate its effects on LPS-induced early responses in vivo. Early responses measured 1 h af...

journal_title：Biochemical and biophysical research communications

authors： Aoki K,Ishida Y,Kikuta N,Kawai H,Kuroiwa M,Sato H

更新日期：2002-06-28 00:00:00

abstract：:A single base change resulting in the substitution of Cys for Arg at position 519 of the type II collagen triple helix is a predisposing factor in the pathogenesis of a precocious-onset form of familial osteoarthritis associated with a mild chondrodysplasia. Cartilage obtained at the time of total knee replacement in ...

journal_title：Biochemical and biophysical research communications

authors： Holderbaum D,Malemud CJ,Moskowitz RW,Haqqi TM

更新日期：1993-05-14 00:00:00

abstract：:The ability of the rat brain to activate the phosphorothionate insecticide parathion to its potent anticholinesterase metabolite paraoxon in situ was observed by ligating the posterior portion of the circulatory system and thus removing the liver from the circulation. Under these conditions no acetylcholinesterase inh...

journal_title：Biochemical and biophysical research communications

authors： Chambers JE,Munson JR,Chambers HW

更新日期：1989-11-30 00:00:00

abstract：:Antisense oligonucleotides were modified by their ends with hydrophobic substituents which permitted enhancing their activity. The effect of hydrophobized oligonucleotides on reproduction of Herpes Simplex Virus type 1 in Vero cells was studied. Two types of oligonucleotides were used: a 12-mer complementary to the sp...

journal_title：Biochemical and biophysical research communications

authors： Vinogradov SV,Suzdaltseva Y,Alakhov VYu,Kabanov AV

更新日期：1994-09-15 00:00:00

abstract：:Hereditary multiple exostoses (EXT) is an autosomal dominant disorder that is characterized by the appearance of multiple outgrowths of the long bones (exostoses) at their epiphyses. Genetical heterogeneities have segregated at least on chromosome 8, 11, and 19 and been designated EXT1, EXT2, and EXT3, respectively. R...

journal_title：Biochemical and biophysical research communications

authors： Saito T,Seki N,Yamauchi M,Tsuji S,Hayashi A,Kozuma S,Hori T

更新日期：1998-02-04 00:00:00

abstract：:beta-Amyloid peptide (beta A) is a major fibrillar component of neuritic plaques in Alzheimer's disease (AD) brains and is related to the pathogenesis of the disease. In this study, using electron microscopy, we describe herein the results concerning the efficacy of compounds that can dissolve preformed beta A fibrils...

journal_title：Biochemical and biophysical research communications

authors： Nguyen KV,Gendrault JL,Wolff CM

更新日期：2002-03-08 00:00:00

abstract：:Hemangioma is a benign tumor derived from abnormal blood vessel growth. Unlike other vascular tumor counterparts, a hemangioma is known to proliferate during its early stage but it is followed by a stage of involution where regression of the tumor occurs. The critical onset leading to the involution of hemangioma is c...

journal_title：Biochemical and biophysical research communications

authors： Kim KJ,Yun JH,Heo JI,Lee EH,Min HS,Choi TH,Cho CH

更新日期：2014-11-14 00:00:00

abstract：:The insulin receptor gene is induced 8 to 10-fold during adipocyte differentiation. Plasmids containing the promoter, exon 1 and a portion of the first intron from either the mouse or human gene are able to modulate the expression of an insulin receptor/CAT gene 3 to 7-fold during differentiation. We have shown that s...

journal_title：Biochemical and biophysical research communications

authors： McKeon C,Accili D,Chen H,Pham T,Walker GE

更新日期：1997-11-26 00:00:00

abstract：:In vivo gluconeogenesis from (3-13 C)alanine was evident in terminal instar Manduca sexta larvae from the selective fractional 13C enrichment in trehalose, a disaccharide of glucose and the major blood sugar of insects. De novo glucose synthesis was observed in insects fed a low carbohydrate diet for 1 or more days. G...

journal_title：Biochemical and biophysical research communications

authors： Thompson SN

更新日期：1997-08-28 00:00:00

abstract：:A newly identified human peptide, adrenomedullin (AM) increased cAMP levels with dose and time dependencies in a manner similar to that of human calcitonin gene-related peptide (CGRP) in rat vascular smooth muscle cells (VSMC). The EC50 value of human AM is 2 x 10(-8) M which is slightly higher than that of CGRP (8.5 ...

journal_title：Biochemical and biophysical research communications

authors： Ishizaka Y,Ishizaka Y,Tanaka M,Kitamura K,Kangawa K,Minamino N,Matsuo H,Eto T

更新日期：1994-04-15 00:00:00

abstract：:A voltage-activated proton current in human cardiac fibroblasts, measured using the whole-cell recording configuration of the patch-clamp technique, is reported. Increasing the pH of the bathing solution shifted the current activation threshold to more negative potentials and increased both the current amplitude and i...

journal_title：Biochemical and biophysical research communications

authors： El Chemaly A,Guinamard R,Demion M,Fares N,Jebara V,Faivre JF,Bois P

更新日期：2006-02-10 00:00:00

abstract：:Signaling by stem cell factor and Kit, its receptor, play important roles in gametogenesis, hematopoiesis, mast cell development and function, and melanogenesis. Moreover, human and mouse embryonic stem cells express Kit transcripts. Stem cell factor exists as both a soluble and a membrane-bound glycoprotein while Kit...

journal_title：Biochemical and biophysical research communications

authors： Roskoski R Jr

更新日期：2005-12-23 00:00:00

abstract：:DENN domains are found in a variety of signaling proteins but their exact function remains undefined. Some of the DENN-containing proteins, such as rat Rab3GEP (Rab3 GDP/GTP exchange protein) or mouse Rab6IP1 (Rab6 interacting protein 1) interact with GTPases of the Rab family. Others, such as human MADD (MAP (Mitogen...

journal_title：Biochemical and biophysical research communications

authors： Levivier E,Goud B,Souchet M,Calmels TP,Mornon JP,Callebaut I

更新日期：2001-09-28 00:00:00

abstract：:Cellular uptake of succinylated catalase (Suc-CAT; Mw 227 kDa), bovine serum albumin (Suc-BSA; Mw 70 kDa), superoxide dismutase (Suc-SOD; Mw 34 kDa) and soybean trypsin inhibitor (Suc-STI; Mw 21 kDa) was studied using primary cultures of bovine brain microvessel endothelial cells (BMECs) developed as an in vitro model...

journal_title：Biochemical and biophysical research communications

authors： Tokuda H,Masuda S,Takakura Y,Sezaki H,Hashida M

更新日期：1993-10-15 00:00:00

abstract：:A polymerase chain reaction-generated mouse ACTH-R probe was used to screen a mouse genomic library, and a clone of 13kb containing the entire coding sequence was isolated. The coding sequence shows 84% homology with the human gene at the DNA level and encodes a peptide with 89% homology to the human ACTH-R. This gene...

journal_title：Biochemical and biophysical research communications

authors： Cammas FM,Kapas S,Barker S,Clark AJ

更新日期：1995-07-26 00:00:00