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c-myc gene expression in human cells is controlled by glucose.

Abstract：

:The c-myc oncogene is implicated in normal growth and differentiation processes. Human cell lines IM9 and HepG2 stably cultured at "low" glucose concentrations (5.5 mM) show c-myc mRNA levels 3-4 times higher than cells cultured at "high" glucose concentrations (25 nM). D-fructose (a metabolizable exose) substitutes for D-glucose in reducing c-myc expression while 3-ortho-methylglucose (a non metabolizable exose) is uneffective. c-myc expression is up-regulated (by PMA) or down-regulated (by dexamethasone and long-term exposure to FCS) in human cells cultured at "low" glucose but not in cells cultured at "high" glucose. We previously demonstrated that insulin receptor gene expression in human cell lines in enhanced by glucose. Therefore, glucose controls in an opposite way the expression of two genes important in the regulation of eukaryotic cell growth and differentiation.

journal_name

Biochem Biophys Res Commun

journal_title

Biochemical and biophysical research communications

authors

Briata P,Laurino C,Gherzi R

doi

10.1016/0006-291x(89)92719-8

subject

Has Abstract

pub_date

1989-12-29 00:00:00

pages

1123-9

issue

3

eissn

0006-291X

issn

1090-2104

pii

0006-291X(89)92719-8

journal_volume

165

pub_type

杂志文章

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